The role of miRNA-29b1, MMP-2, MMP-9 mRNAs, and proteins in early diagnosis of HCC

Dasgupta P, Henshaw C, Youlden DR, Clark PJ, Aitken JF, Baade PD (2020) Global trends in incidence rates of primary adult liver cancers: a systematic review and meta-analysis. Front Oncol 10:171

Article  PubMed  PubMed Central  Google Scholar 

Gao T, Zhi J, Mu C, Gu S, Xiao J, Yang J et al (2018) One-step detection for two serological biomarker species to improve the diagnostic accuracy of hepatocellular carcinoma. Talanta 178:89–93

Article  CAS  PubMed  Google Scholar 

Cadier B, Bulsei J, Nahon P, Seror O, Laurent A, Rosa I et al (2017) Early detection and curative treatment of hepatocellular carcinoma: a cost-effectiveness analysis in France and in the United States. Hepatology 65(4):1237–1248

Article  PubMed  Google Scholar 

Benson AB 3rd, Abrams TA, Ben-Josef E, Bloomston PM, Botha JF, Clary BM et al (2009) NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Cancer Netw JNCCN 7(4):350–391

Article  CAS  PubMed  Google Scholar 

Johnson P (1999) Role of alpha-fetoprotein in the diagnosis and management of hepatocellular carcinoma. J Gastroenterol Hepatol 14(5s):S32–S36

Article  PubMed  Google Scholar 

Trevisani F, D’Intino PE, Morselli-Labate AM, Mazzella G, Accogli E, Caraceni P et al (2001) Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34(4):570–575

Article  CAS  PubMed  Google Scholar 

Han L-L, Lv Y, Guo H, Ruan Z-P, Nan K-J (2014) Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy. World J Gastroenterol WJG 20(30):10249

Article  PubMed  Google Scholar 

Chen S, Chen H, Gao S, Qiu S, Zhou H, Yu M et al (2017) Differential expression of plasma microRNA-125b in hepatitis B virus-related liver diseases and diagnostic potential for hepatitis B virus-induced hepatocellular carcinoma. Hepatol Res 47(4):312–320

Article  CAS  PubMed  Google Scholar 

Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology (Baltimore, MD) 53(3):1020

Article  PubMed  Google Scholar 

Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2(3):161–174

Article  CAS  PubMed  Google Scholar 

Zítka O, Kukacka J, Krizkov S, Húska D, Adam V, Masarik M et al (2010) Matrix metalloproteinases. Curr Med Chem 17(31):3751–3768

Article  PubMed  Google Scholar 

Groblewska M, Siewko M, Mroczko B, Szmitkowski M (2012) The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer. Folia Histochem Cytobiol 50(1):12–19

Article  PubMed  Google Scholar 

Maolood N, Hardin-Pouzet H, Grange-Messent V (2008) Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus. Eur J Neurosci 27(5):1143–1152

Article  CAS  PubMed  Google Scholar 

McCawley LJ, Li S, Wattenberg EV, Hudson LG (1999) Sustained activation of the mitogen-activated protein kinase pathway: a mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration. J Biol Chem 274(7):4347–4353

Article  CAS  PubMed  Google Scholar 

Kong L, Zhu J, Han W, Jiang X, Xu M, Zhao Y et al (2011) Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study. Acta Diabetol 48:61–69

Article  CAS  PubMed  Google Scholar 

Sternlicht MD, Werb Z (2001) How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17(1):463–516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon MJ (2023) Matrix metalloproteinases as therapeutic targets in breast cancer. Front Oncol 12:1108695

Article  PubMed  PubMed Central  Google Scholar 

Hong EH, Hwang M, Yu H, Park H-H, Cho H, Koh S-H et al (2022) Differential expression of aqueous humor microRNAs in central retinal vein occlusion and its association with matrix metalloproteinases: a pilot study. Sci Rep 12(1):16429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mo M, Peng F, Wang L, Peng L, Lan G, Yu S (2013) Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer. Oncol Lett 6(2):617–623

Article  PubMed  PubMed Central  Google Scholar 

Di Leva G, Garofalo M, Croce CM (2014) MicroRNAs in cancer. Annu Rev Pathol 9:287–314

Article  PubMed  Google Scholar 

Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci 101(9):2999–3004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abba M, Patil N, Allgayer H (2014) MicroRNAs in the regulation of MMPs and metastasis. Cancers 6(2):625–645

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han L, Zhang A, Zhou X, Xu P, Wang G-X, Pu P-Y et al (2010) Downregulation of Dicer enhances tumor cell proliferation and invasion. Int J Oncol 37(2):299–305

CAS  PubMed  Google Scholar 

Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001) Identification of novel genes coding for small expressed RNAs. Science 294(5543):853–858

Article  CAS  PubMed  Google Scholar 

Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, Huang X et al (2011) MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 54(5):1729–1740

Article  CAS  PubMed  Google Scholar 

Chen H-X, Xu X-X, Zhang Z, Tan B-Z, Zhou X-D (2017) MicroRNA-29b inhibits angiogenesis by targeting VEGFA through the MAPK/ERK and PI3K/Akt signaling pathways in endometrial carcinoma. Cell Physiol Biochem 41(3):933–946

Article  CAS  PubMed  Google Scholar 

Li Y, Cai B, Shen L, Dong Y, Lu Q, Sun S et al (2017) MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3. Cancer Lett 397:111–119

Article  CAS  PubMed  Google Scholar 

Zhao X, Liu Y, Li Z, Zheng S, Wang Z, Li W et al (2018) Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa-miR-29b-3p in pancreatic ductal adenocarcinoma. J Cell Mol Med 22(1):655–667

Article  CAS  PubMed  Google Scholar 

Poudyal D, Cui X, Le PM, Hofseth AB, Windust A, Nagarkatti M et al (2013) A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng. PLoS ONE 8(10):e75034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salamat JM, Abbott KL, Flannery PC, Ledbetter EL, Pondugula SR (2022) Interplay between the Cannabinoid system and microRNAs in cancer. ACS Omega 7(12):9995–10000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu F, Zhang Q, Cheng W, Zhang Z, Wang J, Ge J (2013) Effect of miR-29b-1* and miR-29c knockdown on cell growth of the bladder cancer cell line T24. J Int Med Res 41(6):1803–1810

Article  CAS  PubMed  Google Scholar 

Shaker O, Ayeldeen G, Abdelhamid A (2021) The impact of single nucleotide polymorphism in the long non-coding MEG3 gene on microRNA-182 and microRNA-29 expression levels in the development of breast cancer in Egyptian women. Front Genet 12:683809

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashcroft RE (2008) The declaration of Helsinki. In: The Oxford textbook of clinical research ethics, pp 141–8

Kim T-H, Kim SY, Tang A, Lee JM (2019) Comparison of international guidelines for noninvasive diagnosis of hepatocellular carcinoma: 2018 update. Clin Mol Hepatol 25(3):245

Article  PubMed  PubMed Central  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods 25(4):402–408

Article  CAS  PubMed  Google Scholar 

Fernández M, Semela D, Bruix J, Colle I, Pinzani M, Bosch J (2009) Angiogenesis in liver disease. J Hepatol 50(3):604–620

Article  PubMed  Google Scholar 

Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH et al (2010) Effects of MicroRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51(3):836–845

CAS  PubMed  Google Scholar 

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