Roozenbeek B, Maas AI, Menon DK. Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol. 2013;9(4):231–6.

Article  PubMed  Google Scholar 

Filley CM, Kelly JP. White matter and cognition in traumatic brain injury. J Alzheimers Dis. 2018;65(2):345–62.

Article  PubMed  Google Scholar 

Marklund N, Bellander BM, Godbolt AK, Levin H, McCrory P, Thelin EP. Treatments and rehabilitation in the acute and chronic state of traumatic brain injury. J Intern Med. 2019;285(6):608–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

James SL, Theadom A, Ellenbogen RG, Bannick MS, Mountjoy-Venning WC, Lucchesi LR, et al. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):56–87.

Article  Google Scholar 

Lipton ML, Gellella E, Lo C, Gold T, Ardekani BA, Shifteh K, et al. Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: a voxel-wise analysis of diffusion tensor imaging. J Neurotrauma. 2008;25(11):1335–42.

Article  PubMed  Google Scholar 

Armstrong RC, Mierzwa AJ, Marion CM, Sullivan GM. White matter involvement after TBI: clues to axon and myelin repair capacity. Exp Neurol. 2016;275(Pt 3):328–33.

Article  CAS  PubMed  Google Scholar 

Chung S, Fieremans E, Wang X, Kucukboyaci NE, Morton CJ, Babb J, et al. White matter tract integrity: an indicator of axonal pathology after mild traumatic brain injury. J Neurotrauma. 2018;35(8):1015–20.

Article  PubMed  PubMed Central  Google Scholar 

Dent KA, Christie KJ, Bye N, Basrai HS, Turbic A, Habgood M, et al. Oligodendrocyte birth and death following traumatic brain injury in adult mice. PLoS ONE. 2015;10(3):e0121541.

Article  PubMed  PubMed Central  Google Scholar 

Mierzwa AJ, Marion CM, Sullivan GM, McDaniel DP, Armstrong RC. Components of myelin damage and repair in the progression of white matter pathology after mild traumatic brain injury. J Neuropathol Exp Neurol. 2015;74(3):218–32.

Article  PubMed  Google Scholar 

Reeves TM, Smith TL, Williamson JC, Phillips LL. Unmyelinated axons show selective rostrocaudal pathology in the corpus callosum after traumatic brain injury. J Neuropathol Exp Neurol. 2012;71(3):198–210.

Article  PubMed  Google Scholar 

Flygt J, Clausen F, Marklund N. Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts. Restor Neurol Neurosci. 2017;35(2):251–63.

CAS  PubMed  Google Scholar 

Huntemer-Silveira A, Patil N, Brickner MA, Parr AM. Strategies for oligodendrocyte and myelin repair in traumatic CNS injury. Front Cell Neurosci. 2020;14:619707.

Article  CAS  PubMed  Google Scholar 

Song S, Hasan MN, Yu L, Paruchuri SS, Bielanin JP, Metwally S, et al. Microglial-oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury. J Neuroinflammation. 2022;19(1):246.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torup L. Neuroprotection with or without erythropoiesis; sometimes less is more. Brit J Pharmacol. 2007;151(8):1141–2.

Article  CAS  Google Scholar 

Marti HH. Erythropoietin and the hypoxic brain. J Exp Biol. 2004;207(Pt 18):3233–42.

Article  CAS  PubMed  Google Scholar 

Rabie T, Marti HH. Brain protection by erythropoietin: a manifold task. Physiology (Bethesda). 2008;23:263–74.

CAS  PubMed  Google Scholar 

Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, et al. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet. 2015;386(10012):2499–506.

Article  CAS  PubMed  Google Scholar 

Gantner DC, Bailey M, Presneill J, French CJ, Nichol A, Little L, et al. Erythropoietin to reduce mortality in traumatic brain injury: a post-hoc dose-effect analysis. Ann Surg. 2018;267(3):585–9.

Article  PubMed  Google Scholar 

Skrifvars MB, French C, Bailey M, Presneill J, Nichol A, Little L, et al. Cause and timing of death and subgroup differential effects of erythropoietin in the EPO-TBI study. J Neurotrauma. 2018;35(2):333–40.

Article  PubMed  Google Scholar 

Hellewell SC, Yan EB, Alwis DS, Bye N, Morganti-Kossmann MC. Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor. J Neuroinflamm. 2013;10.

Celorrio M, Rhodes J, Shumilov K, Moritz J, Xiao S, Anabayan I, et al. Recombinant human erythropoietin induces neuroprotection, activates MAPK/CREB pathway, and rescues fear memory after traumatic brain injury with delayed hypoxemia in mice. Brain Res. 2022;1795:148074.

Article  CAS  PubMed  Google Scholar 

Mazur M, Miller RH, Robinson S. Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury. J Neurosurg Pediatr. 2010;6(3):206–21.

Article  PubMed  PubMed Central  Google Scholar 

Cho YK, Kim G, Park S, Sim JH, Won YJ, Hwang CH, et al. Erythropoietin promotes oligodendrogenesis and myelin repair following lysolecithin-induced injury in spinal cord slice culture. Biochem Biophys Res Commun. 2012;417(2):753–9.

Article  CAS  PubMed  Google Scholar 

Iwai M, Stetler RA, Xing J, Hu X, Gao Y, Zhang W, et al. Enhanced oligodendrogenesis and recovery of neurological function by erythropoietin after neonatal hypoxic/ischemic brain injury. Stroke. 2010;41(5):1032–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parikh U, Williams M, Jacobs A, Pineda JA, Brody DL, Friess SH. Delayed hypoxemia following traumatic brain injury exacerbates white matter injury. J Neuropathol Exp Neurol. 2016;75(8):731–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis DP, Meade W, Sise MJ, Kennedy F, Simon F, Tominaga G, et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma. 2009;26(12):2217–23.

Article  PubMed  Google Scholar 

Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, et al. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma Injury Infect Crit Care. 2006;61(5):1134–41.

Article  Google Scholar 

Fang R, Markandaya M, DuBose JJ, Cancio LC, Shackelford S, Blackbourne LH. Early in-theater management of combat-related traumatic brain injury: a prospective, observational study to identify opportunities for performance improvement. J Trauma Acute Care Surg. 2015;79(4 Suppl 2):S181–7.

Article  PubMed  Google Scholar 

Celorrio M, Shumilov K, Payne C, Vadivelu S, Friess SH. Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury. Acta Neuropathol Commun. 2022;10(1):10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou ZW, Li F, Zheng ZT, Li YD, Chen TH, Gao WW, et al. Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury. Brain Behav. 2017;7(11).

Chauhan NB, Gatto R. Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury. Brain Res. 2010;1360:177–92.

Article  CAS  PubMed  Google Scholar 

Robertson CS, Hannay HJ, Yamal JM, Gopinath S, Goodman JC, Tilley BC, et al. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA. 2014;312(1):36–47.

Article  PubMed  PubMed Central  Google Scholar 

Yang HJ, Vainshtein A, Maik-Rachline G, Peles E. G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. Nat Commun. 2016;7:10884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castaneyra-Ruiz L, McAllister JP 2nd, Morales DM, Brody SL, Isaacs AM, Limbrick DD Jr. Preterm intraventricular hemorrhage in vitro: modeling the cytopathology of the ventricular zone. Fluids and barriers of the CNS. 2020;17(1):46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau LW, Keough MB, Haylock-Jacobs S, Cua R, Doring A, Sloka S, et al. Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann Neurol. 2012;72(3):419–32.

Article  CAS  PubMed  Google Scholar 

Siebert JR, Osterhout DJ. The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes. J Neurochem. 2011;119(1):176–88.

Article  CAS  PubMed  Google Scholar 

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.

Article  PubMed  Google Scholar 

Zhang L, Chopp M, Zhang RL, Wang L, Zhang J, Wang Y, et al. Erythropoietin amplifies stroke-induced oligodendrogenesis in the rat. PLoS ONE. 2010;5(6):e11016.

Article  PubMed  PubMed Central  Google Scholar