Alasoo K et al (2018) Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response. Nat Genet 50(3):424–431
Article CAS PubMed PubMed Central Google Scholar
Astle WJ et al (2016) The allelic landscape of human blood cell trait variation and links to common complex disease. Cell 167(5):1415–1429
Article CAS PubMed PubMed Central Google Scholar
Aznaourova M et al (2022) Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19. Proc Natl Acad Sci USA 119(36):e2120680119
Article CAS PubMed PubMed Central Google Scholar
Bannister AJ, Kouzarides T (2011) Regulation of chromatin by histone modifications. Cell Res 21(3):381–395
Article CAS PubMed PubMed Central Google Scholar
Barbeira AN et al (2018) Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun 9(1):1825
Article PubMed PubMed Central Google Scholar
Beckmann ND et al (2020) Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease. Nat Commun 11(1):3942
Article CAS PubMed PubMed Central Google Scholar
Benner C et al (2016) FINEMAP: efficient variable selection using summary data from genome-wide association studies. Bioinformatics 32(10):1493–1501
Article CAS PubMed PubMed Central Google Scholar
Bonder MJ et al (2017) Disease variants alter transcription factor levels and methylation of their binding sites. Nat Genet 49(1):131–138
Article CAS PubMed Google Scholar
Bruscadin JJ et al (2021) Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus. Sci Rep 11(1):7321
Article CAS PubMed PubMed Central Google Scholar
Byars SG et al (2017) Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy. PLoS Genet 13(6):e1006328
Article PubMed PubMed Central Google Scholar
Chamberlain LH, Shipston MJ (2015) The physiology of protein S-acylation. Physiol Rev 95(2):341–376
Article CAS PubMed PubMed Central Google Scholar
Chandra V et al (2021) Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants. Nat Genet 53(1):110–119
Article CAS PubMed Google Scholar
Chang L, Zhou G, Xia J (2023) mGWAS-Explorer 20: causal analysis and interpretation of metabolite-phenotype associations. Metabolites 13(7):826
Article CAS PubMed PubMed Central Google Scholar
Chen W et al (2015) Fine mapping causal variants with an approximate Bayesian method using marginal test statistics. Genetics 200(3):719–736
Article PubMed PubMed Central Google Scholar
Chen L et al (2016) Genetic drivers of epigenetic and transcriptional variation in human immune cells. Cell 167(5):1398–1414
Article CAS PubMed PubMed Central Google Scholar
Chen C et al (2022) Pan-cancer analysis of microbiome quantitative trait loci. Cancer Res 82(19):3449–3456
Article CAS PubMed Google Scholar
Chun S et al (2017) Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet 49(4):600–605
Article CAS PubMed PubMed Central Google Scholar
Consortium G.T (2015) Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348(6235):648–660
Consortium, G.T (2013) The Genotype-Tissue Expression (GTEx) project. Nat Genet 45(6):580–585
Cookson W et al (2009) Mapping complex disease traits with global gene expression. Nat Rev Genet 10(3):184–194
Article CAS PubMed PubMed Central Google Scholar
Corces MR et al (2020) Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases. Nat Genet 52(11):1158–1168
Article CAS PubMed PubMed Central Google Scholar
Cuddleston WH et al (2022) Cellular and genetic drivers of RNA editing variation in the human brain. Nat Commun 13(1):2997
Article CAS PubMed PubMed Central Google Scholar
Cui Y et al (2022) 3’aQTL-atlas: an atlas of 3’UTR alternative polyadenylation quantitative trait loci across human normal tissues. Nucleic Acids Res 50(D1):D39–D45
Article CAS PubMed Google Scholar
Currin KW et al (2021) Genetic effects on liver chromatin accessibility identify disease regulatory variants. Am J Hum Genet 108(7):1169–1189
Article CAS PubMed PubMed Central Google Scholar
Degner JF et al (2012) DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482(7385):390–394
Article CAS PubMed PubMed Central Google Scholar
Denault WRP, Jugessur A (2021) Detecting differentially methylated regions using a fast wavelet-based approach to functional association analysis. BMC Bioinformatics 22(1):61
Article CAS PubMed PubMed Central Google Scholar
Dowell RD (2010) Transcription factor binding variation in the evolution of gene regulation. Trends Genet 26(11):468–475
Article CAS PubMed Google Scholar
Draisma HHM et al (2015) Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nat Commun 6:7208
Article CAS PubMed Google Scholar
Elkon R, Ugalde AP, Agami R (2013) Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet 14(7):496–506
Article CAS PubMed Google Scholar
Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. JAMA 318(19):1925–1926
Ernst CW, Steibel JP (2013) Molecular advances in QTL discovery and application in pig breeding. Trends Genet 29(4):215–224
Article CAS PubMed Google Scholar
Evans DM, Davey Smith G (2015) Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu Rev Genomics Hum Genet 16:327–350
Article CAS PubMed Google Scholar
Farashi S et al (2019) Post-GWAS in prostate cancer: from genetic association to biological contribution. Nat Rev Cancer 19(1):46–59
Article CAS PubMed Google Scholar
Fazel-Najafabadi M et al (2022) Discovery and functional characterization of two regulatory variants underlying lupus susceptibility at 2p13.1. Genes (basel) 13(6):1016
Article CAS PubMed Google Scholar
Fleige S, Pfaffl MW (2006) RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med 27(2–3):126–139
Article CAS PubMed Google Scholar
Flint J, Mott R (2001) Finding the molecular basis of quantitative traits: successes and pitfalls. Nat Rev Genet 2(6):437–445
Article CAS PubMed Google Scholar
Flynn ED et al (2022) Transcription factor regulation of eQTL activity across individuals and tissues. PLoS Genet 18(1):e1009719
Article CAS PubMed PubMed Central Google Scholar
Folkersen L et al (2017) Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. PLoS Genet 13(4):e1006706
Comments (0)