Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water

Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Clinical Scientist Investigator, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, North liberty, Iowa, USA

Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

Author Contribution: Writing – review and editing.

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