Comparison of two protocols for the generation of iPSC-derived human astrocytes

Allen NJ, Eroglu C. Cell Biology of Astrocyte-Synapse Interactions. Neuron. 2017;96:697–708.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol (Berl). 2010;119:7–35.

Article  PubMed  Google Scholar 

Colombo E, Farina C. Astrocytes: Key Regulators of Neuroinflammation. Trends Immunol. 2016;37:608–20.

Article  CAS  PubMed  Google Scholar 

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulica P, Grünewald A, Pereira SL. Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective. Front Endocrinol. 2021;12:668517.

Article  Google Scholar 

Kanski R, van Strien ME, van Tijn P, Hol EM. A star is born: new insights into the mechanism of astrogenesis. Cell Mol Life Sci CMLS. 2014;71:433–47.

Article  CAS  PubMed  Google Scholar 

Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015;63:1320–9.

Article  PubMed  Google Scholar 

Zarei-Kheirabadi M, Vaccaro AR, Rahimi-Movaghar V, Kiani S, Baharvand H. An Overview of Extrinsic and Intrinsic Mechanisms Involved in Astrocyte Development in the Central Nervous System. Stem Cells Dev. 2020;29:266–80.

Article  PubMed  Google Scholar 

de Majo M, Koontz M, Rowitch D, Ullian EM. An update on human astrocytes and their role in development and disease. Glia. 2020;68:685–704.

Article  PubMed  Google Scholar 

Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell. 2001;104:365–76.

Article  CAS  PubMed  Google Scholar 

Savchenko E, Teku GN, Boza-Serrano A, Russ K, Berns M, Deierborg T, et al. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Sci Rep. 2019;9:9610.

Article  PubMed  PubMed Central  Google Scholar 

Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, et al. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009;16:245–55.

Article  CAS  PubMed  Google Scholar 

Molofsky AV, Krencik R, Ullian EM, Tsai H, Deneen B, Richardson WD, et al. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012;26:891–907.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jurga AM, Paleczna M, Kadluczka J, Kuter KZ. Beyond the GFAP-Astrocyte Protein Markers in the Brain. Biomolecules. 2021;11:1361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vandenbark AA, Offner H, Matejuk S, Matejuk A. Microglia and astrocyte involvement in neurodegeneration and brain cancer. J Neuroinflammation. 2021;18:298.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett ML, Viaene AN. What are activated and reactive glia and what is their role in neurodegeneration? Neurobiol Dis. 2021;148:105172.

Article  CAS  PubMed  Google Scholar 

Escartin C, Galea E, Lakatos A, O’Callaghan JP, Petzold GC, Serrano-Pozo A, et al. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021;24:312–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escartin C, Guillemaud O, Carrillo-de Sauvage M-A. Questions and (some) answers on reactive astrocytes. Glia. 2019;67:2221–47.

Article  PubMed  Google Scholar 

Engel M, Do-Ha D, Muñoz SS, Ooi L. Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. Cell Mol Life Sci CMLS. 2016;73:3693–709.

Article  CAS  PubMed  Google Scholar 

Chandrasekaran A, Avci HX, Leist M, Kobolák J, Dinnyés A. Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research. Front Cell Neurosci. 2016;10:215.

Article  PubMed  PubMed Central  Google Scholar 

Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, et al. Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Rep. 2015;4:25–36.

Article  CAS  Google Scholar 

Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, et al. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Rep. 2017;9:600–14.

Article  CAS  Google Scholar 

Kumar M, Nguyen NTP, Milanese M, Bonanno G. Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders. Biomolecules. 2022;12:344.

Article  PubMed  PubMed Central  Google Scholar 

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, et al. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease. Stem Cell Rep. 2017;9:1885–97.

Article  CAS  Google Scholar 

Krencik R, Zhang S-C. Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Nat Protoc. 2011;6:1710–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palm T, Bolognin S, Meiser J, Nickels S, Träger C, Meilenbrock R-L, et al. Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia. Sci Rep. 2015;5:16321.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, et al. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Hum Mol Genet. 2017;26:2690–700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brezovakova V, Sykova E, Jadhav S. Astrocytes Derived from Familial and Sporadic Alzheimer’s Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau. Cells. 2022;11:1429.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seo J-E, Li X, Le Y, Mei N, Zhou T, Guo X. High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing. Arch Toxicol. 2023;97:1163–75.

Article  CAS  PubMed  Google Scholar 

Spreng A-S, Brüll M, Leisner H, Suciu I, Leist M. Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation. Cells. 2022;11:2644.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badanjak K, Mulica P, Smajic S, Delcambre S, Tranchevent L-C, Diederich N, et al. iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease. Front Cell Dev Biol. 2021;9:740758.

Article  PubMed  PubMed Central  Google Scholar 

Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel CS, Höing S, et al. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. PLoS ONE. 2013;8:e59252.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao Y, Smyth GK, Shi W. The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads. Nucleic Acids Res. 2019;47:e47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.

Article  PubMed  PubMed Central  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinforma Oxf Engl. 2010;26:139–40.

Article  CAS  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Ser B Methodol. 1995;57:289–300.

Google Scholar 

Warnes GR, Bolker B, Bonebakker L, Gentleman R, Huber W, Liaw A, et al. gplots: Various R Programming Tools for Plotting Data. 2022 [cited 2023 Jan 14]. Available from: https://CRAN.R-project.org/package=gplots

MetaCore Login | Clarivate. [cited 2023 Jan 14]. Available from: https://portal.genego.com/

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