Bettis T, Kim BJ, Hamrick MW. Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse. Osteoporos Int. 2018 Aug;29(8):1713–1720. doi: https://doi.org/10.1007/s00198-018-4570-1. Epub 2018 May 18. PMID: 29777277; PMCID: PMC7861141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kirk B, Feehan J, Lombardi G, Duque G. Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines. Curr Osteoporos Rep. 2020 Aug;18(4):388–400. doi: https://doi.org/10.1007/s11914-020-00599-y. PMID: 32529456.

Article  PubMed  Google Scholar 

Maurel DB, Jähn K, Lara-Castillo N. Muscle-Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies. Biomedicines. 2017 Oct 24;5(4):62. doi: https://doi.org/10.3390/biomedicines5040062. PMID: 29064421; PMCID: PMC5744086.

Article  PubMed  PubMed Central  Google Scholar 

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA. Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nat Med. 2015 Nov;21(11):1262–1271. doi: https://doi.org/10.1038/nm.3961. Epub 2015 Oct 12. PMID: 26457758; PMCID: PMC4636436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loncar G, Cvetinovic N, Lainscak M, Isaković A, von Haehling S. Bone in heart failure. J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):381–393. doi: https://doi.org/10.1002/jcsm.12516. Epub 2020 Feb 22. PMID: 32087616; PMCID: PMC7113538.

Article  PubMed  PubMed Central  Google Scholar 

Edwards MH, Dennison EM, Aihie Sayer A, et al. Osteoporosis and sarcopenia in older age. Bone 2015; 80:126–130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirschfeld HP, Kinsella R, Duque G. Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos Int. 2017 Oct;28(10):2781–2790. doi: https://doi.org/10.1007/s00198-017-4151-8. Epub 2017 Jul 22. PMID: 28733716.

Article  CAS  PubMed  Google Scholar 

Glaser DL, Kaplan FS. Osteoporosis. Definition and clinical presentation. Spine (Phila Pa 1976). 1997 Dec 15;22(24 Suppl):12S–16S. doi: https://doi.org/10.1097/00007632199712151-00003. PMID: 9431639.

Article  CAS  PubMed  Google Scholar 

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16–31. doi: https://doi.org/10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 Jul 1;48(4):601.

Article  PubMed  Google Scholar 

Zimmerman SI, Girman CJ, Buie VC, Chandler J, Hawkes W, Martin A, Holder L, Hebel JR, Sloane PD, Magaziner J. The prevalence of osteoporosis in nursing home residents. Osteoporos Int. 1999;9(2):151–7. doi: https://doi.org/10.1007/s001980050129. PMID: 10367043.

Article  CAS  PubMed  Google Scholar 

Shiba T, Sawaya Y, Hirose T, Sato R, Ishizaka M, Kubo A, Urano T. Features of older community-dwelling adults with osteosarcopenia requiring support or care. J Phys Ther Sci. 2022 May;34(5):341–346. doi: https://doi.org/10.1589/jpts.34.341. Epub 2022 May 1. PMID: 35527844; PMCID: PMC9057679.

Article  PubMed  PubMed Central  Google Scholar 

Kirk B, Zanker J, Duque G. Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers. J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):609–618. doi: https://doi.org/10.1002/jcsm.12567. Epub 2020 Mar 22. PMID: 32202056; PMCID: PMC7296259.

Article  PubMed  PubMed Central  Google Scholar 

Clynes MA, Gregson CL, Bruyère O, Cooper C, Dennison EM. Osteosarcopenia: where osteoporosis and sarcopenia collide. Rheumatology (Oxford). 2021 Feb 1;60(2):529–537.

Article  CAS  PubMed  Google Scholar 

Yoshimura, N.; Muraki, S.; Oka, H.; Iidaka, T.; Kodama, R.; Horii, C.; Kawaguchi, H.; Nakamura, K.; Akune, T.; Tanaka, S. Do sarcopenia and/or osteoporosis increase the risk of frailty? A 4-year observation of the second and third ROAD study surveys. Osteoporos Int. 2018, 29, 2181–2190.

Article  CAS  PubMed  Google Scholar 

Hadjidakis DJ, Androulakis II. Bone remodeling. Ann N Y Acad Sci. 2006 Dec;1092:385–96. doi: https://doi.org/10.1196/annals.1365.035. PMID: 17308163.

Article  CAS  PubMed  Google Scholar 

Vasikaran S, Eastell R, Bruyère O, Foldes AJ, Garnero P, Griesmacher A, McClung M, Morris HA, Silverman S, Trenti T, Wahl DA, Cooper C, Kanis JA; IOF-IFCC Bone Marker Standards Working Group. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2011 Feb;22(2):391–420. doi: https://doi.org/10.1007/s00198-010-1501-1. Epub 2010 Dec 24. PMID: 21184054.

Article  CAS  PubMed  Google Scholar 

Vilaca T, Gossiel F, Eastell R. Bone Turnover Markers: Use in Fracture Prediction. J Clin Densitom. 2017 Jul-Sep;20(3):346–352. doi: https://doi.org/10.1016/j.jocd.2017.06.020. Epub 2017 Jul 14. PMID: 28716498.

Article  PubMed  Google Scholar 

Marques EA, Gudnason V, Lang T, Sigurdsson G, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB. Association of bone turnover markers with volumetric bone loss, periosteal apposition, and fracture risk in older men and women: the AGES-Reykjavik longitudinal study. Osteoporos Int. 2016 Dec;27(12):3485–3494. doi: https://doi.org/10.1007/s00198-016-3675-7. Epub 2016 Jun 24. PMID: 27341810; PMCID: PMC5560053.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kirk B, Lieu N, Vogrin S, Sales M, Pasco JA, Duque G. Serum levels of C-Terminal Telopeptide (CTX) are Associated with Muscle Function in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2022 Oct 6;77(10):2085–2092. doi: https://doi.org/10.1093/gerona/glac008. PMID: 35018430.

Article  CAS  PubMed  Google Scholar 

Bonnet N, Bourgoin L, Biver E, Douni E, Ferrari S. RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass. J Clin Invest. 2019 May 23;129(8):3214–3223. doi: https://doi.org/10.1172/JCI125915. Erratum in: J Clin Invest. 2020 Jun 1;130(6):3329. PMID: 31120440; PMCID: PMC6668701.

Article  PubMed  PubMed Central  Google Scholar 

Greenspan SL, Perera S, Ferchak MA, Nace DA, Resnick NM. Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial. JAMA Intern Med. 2015 Jun;175(6):913–21. doi: https://doi.org/10.1001/jamainternmed.2015.0747. PMID: 25867538; PMCID: PMC4843134.

Article  PubMed  PubMed Central  Google Scholar 

National Osteoporosis Foundation. Physician’s Guide to Prevention and Treatment of Osteoporosis. Belle Mead, NJ: Excerpta Medica; 2003.

Google Scholar 

Greenblatt MB, Tsai JN, Wein MN. Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2017 Feb;63(2):464–474. doi: https://doi.org/10.1373/clinchem.2016.259085. Epub 2016 Dec 9. PMID: 27940448; PMCID: PMC5549920.

Article  CAS  PubMed  Google Scholar 

Abellan van Kan G, Rolland Y, Andrieu S et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009; 13: 881–9.

Article  CAS  PubMed  Google Scholar 

Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J. Gait speed and survival in older adults. JAMA. 2011 Jan 5;305(1):50–8. doi: https://doi.org/10.1001/jama.2010.1923. PMID: 21205966; PMCID: PMC3080184.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Csuka M, McCarty DJ. Simple method for measurement of lower extremity muscle strength. Am J Med. 1985 Jan;78(1):77–81. doi: https://doi.org/10.1016/0002-9343(85)90465-6. PMID: 3966492.

Article  CAS  PubMed  Google Scholar 

Binder EF, Miller JP, Ball LJ. Development of a test of physical performance for the nursing home setting. Gerontologist. 2001 Oct;41(5):671–9. doi: https://doi.org/10.1093/geront/41.5.671. PMID: 11574712.

Article  CAS  PubMed  Google Scholar 

Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995 Mar 2;332(9):556–61. doi: https://doi.org/10.1056/NEJM199503023320902. PMID: 7838189; PMCID: PMC9828188.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146–56. doi: https://doi.org/10.1093/gerona/56.3.m146. PMID: 11253156.

Article  CAS  PubMed  Google Scholar 

Rigler SK, Studenski S, Wallace D, Reker DM, Duncan PW. Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehabil. 2002 Jun;16(4):420–8. doi: https://doi.org/10.1191/0269215502cr515oa. PMID: 12061477.

Article  PubMed  Google Scholar 

Ivaska KK, McGuigan FE, Malmgren L, Gerdhem P, Johansson H, Kanis JA, Akesson KE. Bone Turnover Marker Profiling and Fracture Risk in Older Women: Fracture Risk from Age 75 to 90. Calcif Tissue Int. 2022 Sep;111(3):288–299. doi: https://doi.org/10.1007/s00223-022-00996-8. Epub 2022 Jun 24. PMID: 35750934; PMCID: PMC9395308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garnero P, Hausherr E, Chapuy MC, Marcelli C, Grandjean H, Muller C, Cormier C, Bréart G, Meunier PJ, Delmas PD. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS Prospective Study. J Bone Miner Res. 1996 Oct;11(10):1531–8. doi: https://doi.org/10.1002/jbmr.5650111021. PMID: 8889854.