Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsy
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https://doi.org/10.56042/ijeb.v61i09.1547Title: Effect of KATP openers and blockers on AKT and mTOR mRNA levels in the hippocampus and cortex of rats with penicillin ınduced epilepsyAuthors:
Ümit, KılıçHayriye, SoytürkKeywords: Antidiabetic;Cellular stress;Epileptogenesis;Glibenclamide;PinacidilIssue Date: Sep-2023Publisher: NIScPR-CSIR, IndiaAbstract: Opening or closing of KATP channels affects some signaling pathways in the brain. These signaling pathways are thought
to be associated with epilepsy. Here, we investigated the effect of KATP channel opener and blocker on the AKT mTOR
mRNA expressions in the hippocampus and cortex regions in the penicillin model of epilepsy in rats. Four groups were
created viz. Control (C), Epilepsy (E), Epilepsy-Opener (E-O) and Epilepsy-Blocker (E-B). Epileptic focus was created by
administering penicillin into the brain, and the seizure-related AKT, mTOR mRNA levels were determined by qPCR on
days 1st, 4th, and 8th after the seizure. The AKT mRNA expression levels in the hippocampus were statistically significant
(P Page(s): 681-686ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:
IJEB Vol.61(09) [September 2023]IJEB Vol.61(09) [September 2023]Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.
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