[1] Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: a population-based study. Lancet 2006; 368: 1005−1011. doi: 10.1016/S0140-6736(06)69208-8 [2] Coffey S, Roberts-Thomson R, Brown A, et al. Global epidemiology of valvular heart disease. Nat Rev Cardiol 2021; 18: 853−864. doi: 10.1038/s41569-021-00570-z [3] Davidson LJ, Davidson CJ. Transcatheter treatment of valvular heart disease: a review. JAMA 2021; 325: 2480−2494. doi: 10.1001/jama.2021.2133 [4] Mack M, Carroll JD, Thourani V, et al. Transcatheter mitral valve therapy in the United States: a report from the STS-ACC TVT Registry. J Am Coll Cardiol 2021; 78: 2326−2353. doi: 10.1016/j.jacc.2021.07.058 [5] Goldfarb M, Lauck S, Webb JG, et al. Malnutrition and mortality in frail and non-frail older adults undergoing aortic valve replacement. Circulation 2018; 138: 2202−2211. doi: 10.1161/CIRCULATIONAHA.118.033887 [6] Afilalo J, Lauck S, Kim DH, et al. Frailty in older adults undergoing aortic valve replacement: the FRAILTY-AVR study. J Am Coll Cardiol 2017; 70: 689−700. doi: 10.1016/j.jacc.2017.06.024 [7] Kundi H, Popma JJ, Reynolds MR, et al. Frailty and related outcomes in patients undergoing transcatheter valve therapies in a nationwide cohort. Eur Heart J 2019; 40: 2231−2239. doi: 10.1093/eurheartj/ehz187 [8] Grigioni F, Clavel MA, Vanoverschelde JL, et al. The MIDA Mortality Risk Score: development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation. Eur Heart J 2018; 39: 1281−1291. doi: 10.1093/eurheartj/ehx465 [9] Raposeiras-Roubin S, Adamo M, Freixa X, et al. A score to assess mortality after percutaneous mitral valve repair. J Am Coll Cardiol 2022; 79: 562−573. doi: 10.1016/j.jacc.2021.11.041 [10] Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129: 2440−2492. doi: 10.1161/CIR.0000000000000029 [11] Xu H, Liu Q, Cao K, et al. Distribution, characteristics, and management of older patients with valvular heart disease in China: China-DVD Study. JACC Asia 2022; 2: 354−365. doi: 10.1016/j.jacasi.2021.11.013 [12] Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461−470. doi: 10.7326/0003-4819-130-6-199903160-00002 [13] Adamo M, Capodanno D, Cannata S, et al. Comparison of three contemporary surgical scores for predicting all-cause mortality of patients undergoing percutaneous mitral valve repair with the MitraClip system (from the multicenter GRASP-IT registry). Am J Cardiol 2015; 115: 107−112. doi: 10.1016/j.amjcard.2014.09.051 [14] Provenchère S, Chevalier A, Ghodbane W, et al. Is the EuroSCORE II reliable to estimate operative mortality among octogenarians? PLoS One 2017; 12: e0187056. doi: 10.1371/journal.pone.0187056 [15] Vahanian A, Beyersdorf F, Praz F, et al. 2021 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J 2022; 43: 561−632. doi: 10.1093/eurheartj/ehab395 [16] Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2021; 143: e35−e71. doi: 10.1161/CIR.0000000000000932 [17] Kavsur R, Spieker M, Iliadis C, et al. Mitral Regurgitation International Database (MIDA) score predicts outcome in patients with heart failure undergoing transcatheter edge-to-edge mitral valve repair. J Am Heart Assoc 2021; 10: e019548. doi: 10.1161/JAHA.120.019548 [18] Spieker M, Zweck E, Pfister R, et al. Risk scores for mortality prediction after transcatheter mitral valve repair. J Am Coll Cardiol 2022; 79: e477−e478. doi: 10.1016/j.jacc.2022.03.382 [19] Chiarito M, Pagnesi M, Martino EA, et al. Outcome after percutaneous edge-to-edge mitral repair for functional and degenerative mitral regurgitation: a systematic review and meta-analysis. Heart 2018; 104: 306−312. doi: 10.1136/heartjnl-2017-311412 [20] Bedogni F, Popolo Rubbio A, Grasso C, et al. Italian Society of Interventional Cardiology (GIse) registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO): impact of valve disease aetiology and residual mitral regurgitation after MitraClip implantation. Eur J Heart Fail 2021; 23: 1364−1376. doi: 10.1002/ejhf.2159 [21] Yuan L, Chang M, Wang J. Abdominal obesity, body mass index and the risk of frailty in community-dwelling older adults: a systematic review and meta-analysis. Age Ageing 2021; 50: 1118−1128. doi: 10.1093/ageing/afab039 [22] Lee CT, Chen MZ, Yip CYC, et al. Prevalence of anemia and its association with frailty, physical function and cognition in community-dwelling older adults: findings from the HOPE study. J Nutr Health Aging 2021; 25: 679−687. doi: 10.1007/s12603-021-1625-3 [23] Shannon CM, Ballew SH, Daya N, et al. Serum albumin and risks of hospitalization and death: findings from the Atherosclerosis Risk in Communities study. J Am Geriatr Soc 2021; 69: 2865−2876. doi: 10.1111/jgs.17313