Changes in brain structure in subjects with resistance to thyroid hormone due to THRB mutations

Bernal J. Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007;3(3):249–59.

Article  CAS  PubMed  Google Scholar 

Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol. 2004;16(10):809–18.

Article  CAS  PubMed  Google Scholar 

Göbel A, Heldmann M, Göttlich M, Dirk AL, Brabant G, Münte TF. Effect of experimental thyrotoxicosis on Brain Gray Matter: a voxel-based Morphometry Study. Eur Thyroid J. 2015;4(Suppl 1):113–8.

Article  PubMed  PubMed Central  Google Scholar 

Göbel A, Heldmann M, Göttlich M, Goerges R, Nieberding R, Sartorius A, et al. Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: a pilot study. J Neuroendocrinol. 2019;31(4):e12707.

Article  PubMed  Google Scholar 

Münte TF, Lill C, Otting G, Brabant G. Cognitive changes in short-term hypothyroidism assessed with event-related brain potentials. Psychoneuroendocrinology. 2004;29(9):1109–18.

Article  PubMed  Google Scholar 

Münte TF, Radamm C, Johannes S, Brabant G. Alterations of cognitive functions induced by exogenous application of thyroid hormones in healthy men: a double-blind cross-over study using event-related brain potentials. Thyroid. 2001;11(4):385–91.

Article  PubMed  Google Scholar 

Singh S, Modi S, Bagga D, Kaur P, Shankar LR, Khushu S. Voxel-based morphometric analysis in hypothyroidism using diffeomorphic anatomic registration via an exponentiated lie algebra algorithm approach. J Neuroendocrinol. 2013;25(3):229–34.

Article  CAS  PubMed  Google Scholar 

Moran C, Chatterjee K. Resistance to thyroid hormone alpha-emerging definition of a disorder of thyroid hormone action. J Clin Endocrinol Metab. 2016;101(7):2636–9.

Article  CAS  PubMed  Google Scholar 

Schoenmakers N, Moran C, Peeters RP, Visser T, Gurnell M, Chatterjee K. Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha. Biochim Biophys Acta. 2013;1830(7):4004–8.

Article  CAS  PubMed  Google Scholar 

Pappa T, Refetoff S. Human Genetics of thyroid hormone receptor Beta: resistance to thyroid hormone Beta (RTHbeta). Methods Mol Biol. 2018;1801:225–40.

Article  CAS  PubMed  Google Scholar 

Frank-Raue K, Lorenz A, Haag C, Hoppner W, Boll HU, Knorr D, et al. Severe form of thyroid hormone resistance in a patient with homozygous/hemizygous mutation of T3 receptor gene. Eur J Endocrinol. 2004;150(6):819–23.

Article  CAS  PubMed  Google Scholar 

Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, et al. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999;104(3):291–300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Refetoff S, Weiss RE, Usala SJ. The syndromes of resistance to thyroid hormone. Endocr Rev. 1993;14(3):348–99.

CAS  PubMed  Google Scholar 

Onigata K, Szinnai G. Resistance to thyroid hormone. Endocr Dev. 2014;26:118–29.

Article  PubMed  Google Scholar 

Campi I, Cammarata G, Bianchi Marzoli S, Beck-Peccoz P, Santarsiero D, Dazzi D, et al. Retinal photoreceptor functions are compromised in patients with resistance to thyroid hormone syndrome (RTHbeta). J Clin Endocrinol Metab. 2017;102(7):2620–7.

Article  PubMed  Google Scholar 

Martinez Lopez AB, Moreno Navarro JC, Maldonado Belmonte MJ, Roldan Martin MB. [Resistance to thyroid hormone and attention deficit hyperactivity disorder]. An Pediatr (Barc). 2013;78(4):274–5.

CAS  PubMed  Google Scholar 

Rohrer T, Gassmann K, Pohlenz J, Dorr HG. [Resistance to thyroid hormone - goiter and attention deficit-hyperactivity disorder as main manifestation]. Dtsch Med Wochenschr. 2002;127(23):1250–2.

Article  CAS  PubMed  Google Scholar 

Stein MA, Weiss RE, Refetoff S. Neurocognitive characteristics of individuals with resistance to thyroid hormone: comparisons with individuals with attention-deficit hyperactivity disorder. J Dev Behav Pediatr. 1995;16(6):406–11.

Article  CAS  PubMed  Google Scholar 

Weiss RE, Stein MA, Refetoff S. Behavioral effects of liothyronine (L-T3) in children with attention deficit hyperactivity disorder in the presence and absence of resistance to thyroid hormone. Thyroid. 1997;7(3):389–93.

Article  CAS  PubMed  Google Scholar 

Ashburner J, Friston KJ. Unified segmentation. NeuroImage. 2005;26(3):839–51.

Article  PubMed  Google Scholar 

Nemoto K. [Understanding Voxel-Based Morphometry]. Brain Nerve. 2017;69(5):505–11.

PubMed  Google Scholar 

Zhang W, Song L, Yin X, Zhang J, Liu C, Wang J, et al. Grey matter abnormalities in untreated hyperthyroidism: a voxel-based morphometry study using the DARTEL approach. Eur J Radiol. 2014;83(1):e43–8.

Article  PubMed  Google Scholar 

Ittermann T, Wittfeld K, Nauck M, Bulow R, Hosten N, Volzke H, et al. High thyrotropin is Associated with reduced hippocampal volume in a Population-Based study from Germany. Thyroid. 2018;28(11):1434–42.

Article  CAS  PubMed  Google Scholar 

Kabani N, Le Goualher G, MacDonald D, Evans AC. Measurement of cortical thickness using an automated 3-D algorithm: a validation study. NeuroImage. 2001;13(2):375–80.

Article  CAS  PubMed  Google Scholar 

Clairman H, Skocic J, Lischinsky JE, Rovet J. Do children with congenital hypothyroidism exhibit abnormal cortical morphology? Pediatr Res. 2015;78(3):286–97.

Article  CAS  PubMed  Google Scholar 

Leonard CM, Martinez P, Weintraub BD, Hauser P. Magnetic resonance imaging of cerebral anomalies in subjects with resistance to thyroid hormone. Am J Med Genet. 1995;60(3):238–43.

Article  CAS  PubMed  Google Scholar 

Gunbey HP, Has AC, Aslan K, Saglam D, Avci U, Sayit AT, et al. Microstructural white matter abnormalities in hypothyroidism evaluation with diffusion tensor imaging tract-based spatial statistical analysis. Radiol Med. 2021;126(2):283–90.

Article  PubMed  Google Scholar 

Heldmann M, Chatterjee K, Moran C, Rogge B, Steinhardt J, Wagner-Altendorf T et al. Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance. Endocr Connect. 2022;11(1).

Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E, et al. The World Health Organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005;35(2):245–56.

Article  PubMed  Google Scholar 

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. Fsl Neuroimage. 2012;62(2):782–90.

Article  PubMed  Google Scholar 

Zhang S, Arfanakis K. Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences. NeuroImage. 2018;172:40–50.

Article  PubMed  Google Scholar 

Dahnke R, Yotter RA, Gaser C. Cortical thickness and central surface estimation. NeuroImage. 2013;65:336–48.

Article  PubMed  Google Scholar 

Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage. 2006;31(3):968–80.

Article  PubMed  Google Scholar 

Rorden C, Brett M. Stereotaxic display of brain lesions. Behav Neurol. 2000;12(4):191–200.

Article  PubMed  Google Scholar 

Marie D, Jobard G, Crivello F, Perchey G, Petit L, Mellet E, et al. Descriptive anatomy of Heschl’s gyri in 430 healthy volunteers, including 198 left-handers. Brain Struct Funct. 2015;220(2):729–43.

Article  CAS  PubMed  Google Scholar 

Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Nishiyama S, et al. Heschl’s Gyrus Duplication Pattern in individuals at risk of developing psychosis and patients with Schizophrenia. Front Behav Neurosci. 2021;15:647069.

Article  PubMed  PubMed Central  Google Scholar 

Welniarz Q, Dusart I, Roze E. The corticospinal tract: evolution, development, and human disorders. Dev Neurobiol. 2017;77(7):810–29.

Article  PubMed  Google Scholar 

Han JS, Seo HS, Lee YH, Lee H, Suh SI, Jeong EK, et al. Fractional anisotropy and diffusivity changes in thyroid-associated orbitopathy. Neuroradiology. 2016;58(12):1189–96.

Article  PubMed  Google Scholar 

Krieger TG, Moran CM, Frangini A, Visser WE, Schoenmakers E, Muntoni F, et al. Mutations in thyroid hormone receptor alpha1 cause premature neurogenesis and progenitor cell depletion in human cortical development. Proc Natl Acad Sci U S A. 2019;116(45):22754–63.

Article  CAS  PubMed  PubMed Central 

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