Green DR. The mitochondrial pathway of apoptosis part I: MOMP and beyond. Cold Spring Harb Perspect Biol. 2022;14:a041038.

Article  CAS  PubMed  Google Scholar 

Green DR. The mitochondrial pathway of apoptosis part II: the BCL-2 protein family. Cold Spring Harb Perspect Biol. 2022;14:a041046.

Article  CAS  PubMed  Google Scholar 

Green DR. Nonapoptotic cell death pathways. Cold Spring Harb Perspect Biol. 2022;14:a041079.

CAS  PubMed  Google Scholar 

Galluzzi L, et al. Molecular mechanisms of cell death: recommendations of the nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25:486–541.

Article  PubMed  PubMed Central  Google Scholar 

Fouquet S, Lugo-Martínez VH, Faussat AM, Renaud F, Cardot P, Chambaz J, Pinçon-Raymond M, Thenet S. Early loss of E-cadherin from cell-cell contacts is involved in the onset of anoikis in enterocytes. J Biol Chem. 2004;279:43061–9.

Article  CAS  PubMed  Google Scholar 

Hofmann C, Obermeier F, Artinger M, Hausmann M, Falk W, Schoelmerich J, Rogler G, Grossmann J. Cell-cell contacts prevent anoikis in primary human colonic epithelial cells. Gastroenterology. 2007;132:587–600.

Article  CAS  PubMed  Google Scholar 

Kumar S, Park SH, Cieply B, Schupp J, Killiam E, Zhang F, Rimm DL, Frisch SM. A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol Cell Biol. 2011;31:4036–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guadamillas MC, Cerezo A, Del Pozo MA. Overcoming anoikis–pathways to anchorage-independent growth in cancer. J Cell Sci. 2011;124:3189–97.

Article  CAS  PubMed  Google Scholar 

Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 2014;15:1243–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Luo Z, Lin L, Sui X, Yu L, Xu C, Zhang R, Zhao Z, Zhu Q, An B, Wang Q. Anoikis-associated lung cancer metastasis: mechanisms and therapies. Cancers. 2022;14:4791.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Popper HH. Progression and metastasis of lung cancer. Cancer Metastasis Rev. 2016;35:75–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamura T, Kurishima K, Nakazawa K, Kagohashi K, Ishikawa H, Satoh H, Hizawa N. Specific organ metastases and survival in metastatic nonsmallcell lung cancer. Mol Clin Oncol. 2015;3:217–21.

Article  PubMed  Google Scholar 

Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553:446–54.

Article  CAS  PubMed  Google Scholar 

Hynds RE, Frese KK, Pearce DR, Grönroos E, Dive C, Swanton C. Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories. Open Biol. 2021;11:200247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Relli V, Trerotola M, Guerra E, Alberti S. Abandoning the notion of non-small cell lung cancer. Trends Mol Med. 2019;25:585–94.

Article  PubMed  Google Scholar 

Schult TA, Lauer MJ, Berker Y, Cardoso MR, Vandergrift LA, Habbel P, Nowak J, Taupitz M, Aryee M, Mino-Kenudson MA, Christiani DC. Screening human lung cancer with predictive models of serum magnetic resonance spectroscopy metabolomics. Proc Natl Acad Sci USA. 2021;118:e2110633118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Y, Li Z, Lazar L, Fang Z, Tang C, Zhao J. Metabolomics workflow for lung cancer: Discovery of biomarkers. Clin Chim Acta. 2019;495:436–45.

Article  CAS  PubMed  Google Scholar 

Ruiying C, Zeyun L, Yongliang Y, Zijia Z, Ji Z, Xin T, Xiaojian Z. A comprehensive analysis of metabolomics and transcriptomics in non-small cell lung cancer. PLoS ONE. 2020;15:e0232272.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi SA, Wu Q, Chen Z, Zhang W, Zhou Y, Mao K, Li J, Li Y, Chen J, Huang Y, Huang Y. High-resolution metabolomic biomarkers for lung cancer diagnosis and prognosis. Sci Rep. 2021;11:1–10.

Article  Google Scholar 

Singh A, Prakash V, Gupta N, Kumar A, Kant R, Kumar D. Serum metabolic disturbances in lung cancer investigated through an elaborative NMR-based serum metabolomics approach. ACS Omega. 2022;7:5510–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu WS, Wu HY, Wang PH, Chen TY, Chen KR, Chang CW, Lee DE, Lin BH, Chang WCW, Liao PC. LCMD: lung cancer metabolome database. Comput Struct Biotechnol J. 2022;20:65–78.

Article  CAS  PubMed  Google Scholar 

Adeshakin FO, Adeshakin AO, Afolabi LO, Yan D, Zhang G, Wan X. Mechanisms for modulating anoikis resistance in cancer and the relevance of metabolic reprogramming. Front Oncol. 2021;11:626577.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM. The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Mol Cell. 2018;69:87–99.

Article  CAS  PubMed  Google Scholar 

Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI. A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer. Nat Commun. 2020;11:1–16.

Article  Google Scholar 

Kodama M, Nakayama KI. A second Warburg-like effect in cancer metabolism: the metabolic shift of glutamine‐derived nitrogen: a shift in glutamine‐derived nitrogen metabolism from glutaminolysis to de novo nucleotide biosynthesis contributes to malignant evolution of cancer. BioEssays. 2020;42:2000169.

Article  CAS  Google Scholar 

Chunhacha P, Sriuranpong V, Chanvorachote P. Epithelialmesenchymal transition mediates anoikis resistance and enhances invasion in pleural effusionderived human lung cancer cells. Oncol Lett. 2013;5:1043–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sirimangkalakitti N, Chamni S, Suwanborirux K, Chanvorachote P. Renieramycin m sensitizes anoikis-resistant H460 lung cancer cells to anoikis. Anticancer Res. 2016;36:1665–71.

CAS  PubMed  Google Scholar 

Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell. 2008;19:797–806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Criollo A, et al. The IKK complex contributes to the induction of autophagy. EMBO J. 2010;29:619–31.

Article  CAS  PubMed  Google Scholar 

Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol. 2011;31:3616–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng TL, Leprivier G, Robertson MD, Chow C, Martin MJ, Laderoute KR, Davicioni E, Triche TJ, Sorensen PH. The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis. Cell Death Differ. 2012;19:501–10.

Article  CAS  PubMed  Google Scholar 

Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature. 2012;485:661–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sundararaman A, Amirtham U, Rangarajan A. Calcium-oxidant signaling network regulates AMP-activated protein kinase (AMPK) activation upon matrix deprivation. J Biol Chem. 2016;291:14410–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19:121–35.

Article  CAS  PubMed  Google Scholar 

Pijuan J, Barceló C, Moreno DF, Maiques O, Sisó P, Marti RM, Macià A, Panosa A. In vitro cell migration, invasion, and adhesion assays: from cell imaging to data analysis. Front Cell Dev Biol. 2019;7:107.

Article  PubMed  PubMed Central  Google Scholar 

Hori S, Nishiumi S, Kobayashi K, Shinohara M, Hatakeyama Y, Kotani Y, Hatano N, Maniwa Y, Nishio W, Bamba T, Fukusaki E. A metabolomic approach to lung cancer. Lung Cancer. 2011;74:284–92.