Developing Targeted Therapies for T Cell Acute Lymphoblastic Leukemia/Lymphoma

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Richard-Carpentier G, et al. Clinical experience with venetoclax combined with chemotherapy for relapsed or refractory T-cell acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk. 2020;20(4):212–8.

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Jain N, et al. A multicenter phase I study combining venetoclax with mini-hyper-CVD in older adults with untreated and relapsed/refractory acute lymphoblastic leukemia. Blood. 2019;134(Supplement_1):3867–7. An excellent preliminary study in older adults with combination chemotherapy that will likely drive future randomized trials.

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Pullarkat VA, et al. Venetoclax and navitoclax in combination with chemotherapy in patients with relapsed or refractory acute lymphoblastic leukemia and lymphoblastic lymphoma. Cancer Discov. 2021;11(6):1440–1453. Early phase study demonstrating effectiveness of BCL-2/BCL-XL combination in relapsed ALL.

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