Muñoz M, Robinson K, Shibli-Rahhal A. Bone health and osteoporosis Prevention and Treatment. Clin Obstet Gynecol. 2020;63(4):770–87.

Article  PubMed  Google Scholar 

Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet (London England). 2011;377(9773):1276–87.

Article  CAS  PubMed  Google Scholar 

Compston JE, McClung MR, Leslie WD, Osteoporosis. Lancet (London England). 2019;393(10169):364–76.

Article  CAS  PubMed  Google Scholar 

Black DM, Rosen CJ. Clinical practice. Postmenopausal osteoporosis. N Engl J Med. 2016;374(3):254–62.

Article  CAS  PubMed  Google Scholar 

Yu F, Xia W. The epidemiology of osteoporosis, associated fragility fractures, and management gap in China. Archives of osteoporosis. 2019;14(1):32.

Article  PubMed  Google Scholar 

Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA. The microbiome, cancer, and cancer therapy. Nat Med. 2019;25(3):377–88.

Article  CAS  PubMed  Google Scholar 

De Luca F, Shoenfeld Y. The microbiome in autoimmune diseases. Clin Exp Immunol. 2019;195(1):74–85.

Article  PubMed  Google Scholar 

DeGruttola AK, Low D, Mizoguchi A, Mizoguchi E. Current understanding of Dysbiosis in Disease in Human and Animal Models. Inflamm Bowel Dis. 2016;22(5):1137–50.

Article  PubMed  Google Scholar 

Takiishi T, Fenero CIM, Câmara NO. Intestinal barrier and gut microbiota: shaping our immune responses throughout life. Tissue barriers. 2017;5(4):e1373208.

Article  PubMed  PubMed Central  Google Scholar 

Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14(3):141–53.

Article  CAS  PubMed  Google Scholar 

Heintz-Buschart A, Wilmes P. Human gut microbiome: function matters. Trends Microbiol. 2018;26(7):563–74.

Article  CAS  PubMed  Google Scholar 

Zhang F, Aschenbrenner D, Yoo JY, Zuo T. The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly. Lancet Microbe. 2022;3(12):e969–83.

Article  CAS  PubMed  Google Scholar 

Ost KS, O’Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O’Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM. Round, J. L. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021;596(7870):114–118.

Ding K, Hua F, Ding W. Gut microbiome and osteoporosis. Aging Dis. 2020;11(2):438–47.

Article  PubMed  PubMed Central  Google Scholar 

Stotzer PO, Johansson C, Mellström D, Lindstedt G, Kilander AF. Bone mineral density in patients with small intestinal bacterial overgrowth. Hepatogastroenterology. 2003;50(53):1415–8.

PubMed  Google Scholar 

Wallace JG, Gohir W, Sloboda DM. The impact of early life gut colonization on metabolic and obesogenic outcomes: what have animal models shown us? J Dev origins health disease. 2016;7(1):15–24.

Article  CAS  Google Scholar 

Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology. 2017;112(Pt B):399–412.

Article  CAS  PubMed  Google Scholar 

Deng Y, Zhou M, Wang J, Yao J, Yu J, Liu W, Wu L, Wang J, Gao R. Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain. Gut Microbes. 2021;13(1):1–16.

Article  PubMed  Google Scholar 

Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, Zárate Rodriguez JG, Rogers AB, Robine N, Loke P, Blaser MJ. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell. 2014;158(4):705–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I, Chung J, Sohn J, Barber CM, Goldfarb DS, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun. 2015;6:7486.

Article  PubMed  Google Scholar 

Rettedal EA, Ilesanmi-Oyelere BL, Roy NC, Coad J, Kruger MC. The gut microbiome is altered in Postmenopausal Women with osteoporosis and Osteopenia. JBMR Plus. 2021;5(3):e10452.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Chen K, Wu C, Chen J, Pan H, Liu Y, Wu P, Yuan J, Huang F, Lang J, Du J, Xu J, Jin K, Chen L. An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice. Am J Clin Nutr. 2021;114(4):1304–13.

Article  PubMed  Google Scholar 

Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, Christensen LP, Jeppesen PB. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017;106(3):909–20.

Article  CAS  PubMed  Google Scholar 

He J, Xu S, Zhang B, Xiao C, Chen Z, Si F, Fu J, Lin X, Zheng G, Yu G, Chen J. Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis. Aging. 2020;12(9):8583–604.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lorenzo J. From the gut to bone: connecting the gut microbiota with Th17 T lymphocytes and postmenopausal osteoporosis. J Clin Investig. 2021;131(5).

Chen L, Yan S, Yang M, Yu F, Wang J, Wang X, Xu H, Shi J, Pan L, Zeng Y, Li S, Li L, You L, Peng Y. The gut microbiome is associated with bone turnover markers in postmenopausal women. Am J Transl Res. 2021;13(11):12601–13.

CAS  PubMed  PubMed Central  Google Scholar 

Locantore P, Del Gatto V, Gelli S, Paragliola RM. Pontecorvi, A. The interplay between Immune System and Microbiota in osteoporosis. Mediat Inflamm. 2020;2020:3686749.

Article  Google Scholar 

Xu Q, Li D, Chen J, Yang J, Yan J, Xia Y, Zhang F, Wang X, Cao H. Crosstalk between the gut microbiota and postmenopausal osteoporosis: mechanisms and applications. Int Immunopharmacol. 2022;110:108998.

Article  CAS  PubMed  Google Scholar 

Huidrom S, Beg MA, Masood T. Post-menopausal osteoporosis and Probiotics. Curr Drug Targets. 2021;22(7):816–22.

Article  CAS  PubMed  Google Scholar 

Rizzoli R, Biver E. Are Probiotics the New Calcium and vitamin D for Bone Health? Curr Osteoporos Rep. 2020;18(3):273–84.

Article  PubMed  Google Scholar 

Laniewski P, Herbst-Kralovetz MM. Connecting microbiome and menopause for healthy ageing. Nat Microbiol. 2022;7(3):354–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peters BA, Santoro N, Kaplan RC, Qi Q. Spotlight on the gut Microbiome in Menopause: current insights. Int J Womens Health. 2022;14:1059–72.

Article  PubMed  PubMed Central  Google Scholar 

Ozaki D, Kubota R, Maeno T, Abdelhakim M, Hitosugi N. Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal japanese women. Osteoporos Int. 2021;32(1):145–56.

Article  CAS  PubMed  Google Scholar 

Yang X, Chang T, Yuan Q, Wei W, Wang P, Song X, Yuan H. Changes in the composition of gut and vaginal microbiota in patients with postmenopausal osteoporosis. Front Immunol. 2022;13:930244.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Starkel P, Fouts DE. Schnabl, B. The fecal mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022;76(4):788–99.

Article  CAS  PubMed  Google Scholar 

Hernandez-Vigueras S, Martinez-Garriga B, Sanchez MC, Sanz M, Estrugo-Devesa A, Vinuesa T, Lopez-Lopez J, Vinas M. Oral microbiota, Periodontal Status, and osteoporosis in postmenopausal females. J Periodontol. 2016;87(2):124–33.

Article  PubMed  Google Scholar 

Wang J, Wang Y, Gao W, Wang B, Zhao H, Zeng Y, Ji Y, Hao D. Diversity analysis of gut microbiota in osteoporosis and osteopenia patients. PeerJ. 2017;5:e3450.

Article  PubMed  PubMed Central  Google Scholar 

Guss JD, Horsfield MW, Fontenele FF, Sandoval TN, Luna M, Apoorva F, Lima SF, Bicalho RC, Singh A, Ley RE, van der Meulen MC, Goldring SR, Hernandez CJ. Alterations to the gut Microbiome Impair Bone Strength and tissue material Properties. J bone mineral research: official J Am Soc Bone Mineral Res. 2017;32(6):1343–53.

Article  CAS  Google Scholar 

Hathaway-Schrader JD, Steinkamp HM, Chavez MB, Poulides NA, Kirkpatrick JE, Chew ME, Huang E, Alekseyenko AV, Aguirre JI, Novince CM. Antibiotic perturbation of Gut Microbiot