Triptolide regulates the balance of Tfr/Tfh in lupus mice

Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365:2110–21. https://doi.org/10.1056/NEJMra1100359.

Article  CAS  PubMed  Google Scholar 

Drner T, Giesecke C, Lipsky PE. Mechanisms of B cell autoimmunity in SLE. Arthritis Res Ther. 2011;13:243.

Article  Google Scholar 

Wang JH, New JS, Xie S, Yang P, Wu Q, Li J, Luo B, Ding Y, Druey KM, Hsu H-C, Mountz JD. Extension of the Germinal Center Stage of B Cell Development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703–12. https://doi.org/10.1002/art.38059.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Woods M, Zou Y-R, Davidson A. Defects in germinal center selection in SLE. Front Immunol. 2015;6:589. https://doi.org/10.3389/fimmu.2015.00425.

Article  CAS  Google Scholar 

Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. Cxc chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 2000;192:1553–62. https://doi.org/10.1084/jem.192.11.1553.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R, Follicular B, Helper T. Cells Express Cxc Chemokine receptor 5, localize to B Cell follicles, and support immunoglobulin production. J Exp Med. 2000;192:1545–52. https://doi.org/10.1084/jem.192.11.1545.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung Y, Tanaka S, Chu F, Nurieva RI, Martinez GJ, Rawal S, Wang Y-H, Lim H, Reynolds JM, Zhou X, Fan H, Liu Z, Neelapu SS, Dong C. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med. 2011;17:983–8. https://doi.org/10.1038/nm.2426.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016;17:1436–46. https://doi.org/10.1038/ni.3578.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma CS, Deenick EK. Human T follicular helper (tfh) cells and disease, Immunol. Cell Biol. 2014;92:64–71. https://doi.org/10.1038/icb.2013.55.

Article  CAS  Google Scholar 

Blanco P, Ueno H, Schmitt N. T follicular helper (tfh) cells in lupus: activation and involvement in SLE pathogenesis. Eur J Immunol. 2016;46:281–90.

Article  CAS  PubMed  Google Scholar 

Tao X, Davis LS, Lipsky PE. Effect of an extract of the chinese Herbal RemedyTripterygium Wilfordii Hook F on Human Immune responsiveness. Arthritis Rheum. 1991;34:1274–81. https://doi.org/10.1002/art.1780341011.

Article  CAS  PubMed  Google Scholar 

Zhou Z-L, Yang Y-X, Ding J, Li Y-C, Miao Z-H. Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep. 2012;29:457. https://doi.org/10.1039/c2np00088a.

Article  CAS  PubMed  Google Scholar 

Zhao X, Tang X, Yan Q, Song H, Li Z, Wang D, Chen H, Sun L. Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation. Int Immunopharmacol. 2019;71:14–21. https://doi.org/10.1016/j.intimp.2019.02.047.

Article  CAS  PubMed  Google Scholar 

Du Z-Y, Li X-Y, Li Y-C, Wang S-Y. Analysis of triptolide-regulated gene expression in jurkat cells by complementary DNA microarray. Acta Pharmacol Sin. 2016;24:864–72.

Google Scholar 

Titov DV, Gilman B, He Q-L, Bhat S, Low W-K, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol. 2011;7:182–8. https://doi.org/10.1038/nchembio.522.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao X, Cai JJ, Lipsky PE. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F. J Pharmacol Exp Ther. 1995;272:1305.

CAS  PubMed  Google Scholar 

Victora GD, Nussenzweig MC, Centers G. Annu Rev Immunol. 2012;30:429–57. https://doi.org/10.1146/annurev-immunol-020711-075032.

Article  CAS  PubMed  Google Scholar 

Liu C, Wang D, Song Y, Lu S, Zhao J, Wang H. Increased circulating CD4 + CXCR5 + FoxP3 + follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients. Int Immunopharmacol. 2018;56:261–8. https://doi.org/10.1016/j.intimp.2018.01.038.

Article  CAS  PubMed  Google Scholar 

Xu B, Wang S, Zhou M, Huang Y, Fu R, Guo C, Chen J, Zhao J, Gaskin F, Fu SM. The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus. Clin Immunol. 2017;183:46–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen PL, Eisenberg RA. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol. 1991;9:243–69. https://doi.org/10.1146/annurev.iy.09.040191.001331.

Article  CAS  PubMed  Google Scholar 

De Groof A, Hémon P, Mignen O, Pers J-O, Wakeland EK, Renaudineau Y, Lauwerys BR. Dysregulated lymphoid cell populations in mouse models of systemic Lupus Erythematosus. Clin Rev Allergy Immunol. 2017;53:181–97. https://doi.org/10.1007/s12016-017-8605-8.

Article  CAS  PubMed  Google Scholar 

Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, Rayner TF, Srivastava M, Divekar DP, Beaton L, Hogan JJ, Fagarasan S, Liston A, Smith KGC, Vinuesa CG. Foxp3 + follicular regulatory T cells control the germinal center response. Nat Med. 2011;17:975–82. https://doi.org/10.1038/nm.2425.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kupchan SM, Court WA, Dailey RG Jr, Gilmore CJ, Bryan RF. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J Am Chem Soc. 1972;94:7194–5.

Article  CAS  PubMed  Google Scholar 

Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. Control of the inheritance of Regulatory T Cell Identity by a cis element in the Foxp3 locus. Cell. 2014;158:749–63. https://doi.org/10.1016/j.cell.2014.07.031.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci USA. 2010;107:204–9. https://doi.org/10.1073/pnas.0903158107.

Article  PubMed  Google Scholar 

Wu Y, He S, Bai B, Zhang L, Xue L, Lin Z, Yang X, Zhu F, He P, Tang W, Zuo J. Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation. Cell Mol Immunol. 2016;13:379–90. https://doi.org/10.1038/cmi.2015.13.

Article  CAS  PubMed  Google Scholar 

Wu Y. Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation. Mol Immunol. 2010;5:12.

Google Scholar 

Xi C, Peng S, Wu Z, Zhou Q, Zhou J. Toxicity of triptolide and the molecular mechanisms involved. Biomed Pharmacother. 2017;90:531–41. https://doi.org/10.1016/j.biopha.2017.04.003.

Article  CAS  PubMed  Google Scholar 

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