Advances in Pharmacology and Pharmacy Vol. 11(4), pp. 289 - 310
DOI: 10.13189/app.2023.110406
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Anusha B. , Ashwini R. , Sakthikumar C. , Darshan Chhajed D. , Darshan Palavalli , Seema S. Rathore *, J. Josephine Leno Jenita
College of Pharmaceutical Sciences, Dayananda Sagar University, India

ABSTRACT

L-Carnitine is a non-essential amino acid and is used as an anti-lipidemic agent with bioavailability＜18% when administered orally. A floating system for L-Carnitine was designed to increase the duration it spends in the stomach without coming in contact with the mucosa by solvent evaporation method. 23 full factorial design model was applied to obtain the experimental runs. The Polymer concentration, stirring rate and stirring time were the constraints of independent variables used to generate the eight experimental runs and were characterized for % yield, in-vitro buoyancy and drug loading. The optimized formulation was studied for its surface morphology, x-ray diffraction, zeta potential and in-vitro release kinetic studies. The formulated microspheres were spherical and free-flowing. They had particle size ranging from 45.75 to 54.79 μm which was suitable for oral delivery. The % yield ranged from 75 to 87.5% and all the microspheres were floating for more than 24hrs. Ethyl cellulose played an important role as a polymer to achieve the buoyancy and to produce gastric retention of drug. The results suggest that L-carnitine as floating microspheres provides controlled drug delivery for the treatment of hyperlipidemia and also improves the bioavailability.

KEYWORDS
Floating Microspheres, L-Carnitine, Ethyl Cellulose, Solvent Evaporation Method, Anti-Hyperlipidemic Agent, Factorial Design

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Anusha B. , Ashwini R. , Sakthikumar C. , Darshan Chhajed D. , Darshan Palavalli , Seema S. Rathore , J. Josephine Leno Jenita , "Design, Evaluation and Optimization of L-carnitine as Floating Microspheres for Hyperlipidemia Using 23 Full Factorial Design," Advances in Pharmacology and Pharmacy, Vol. 11, No. 4, pp. 289 - 310, 2023. DOI: 10.13189/app.2023.110406.

(b). APA Format:
Anusha B. , Ashwini R. , Sakthikumar C. , Darshan Chhajed D. , Darshan Palavalli , Seema S. Rathore , J. Josephine Leno Jenita (2023). Design, Evaluation and Optimization of L-carnitine as Floating Microspheres for Hyperlipidemia Using 23 Full Factorial Design. Advances in Pharmacology and Pharmacy, 11(4), 289 - 310. DOI: 10.13189/app.2023.110406.