Advances in Pharmacology and Pharmacy Vol. 11(4), pp. 245 - 257
DOI: 10.13189/app.2023.110402
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Anitha Puranik , T. C. Taranath *
Environmental Biology and Green Nanotechnology Laboratory, P. G. Department of Studies in Botany, Karnatak University, India

ABSTRACT

The leaf and bark of Erinocarpus nimmonii Grah. ex Dalz., a monotypic, endemic medicinal plant of Malvaceae, were assayed for i) nutritional (proximate, total energy, and minerals) and therapeutic (extractive values, swelling, and foaming index) values using physicochemical parameters, ii) presence of saponin, using Froth Test and Fourier Transform Infrared (FTIR) spectral means, and iii) antimicrobial activity of sequential solvent extracts and minimum inhibitory concentration (MIC) by agar well diffusion and agar dilution methods, respectively. The rich nutritional and mineral value, foaming (saponin), swelling index (mucilage) and maximum soluble extractive values in water and ethanol (SMs) depicted the high nutritional and therapeutic values. Among all sequential extracts, the froth test positively responded to the polar methanol and aqueous extracts, and the FTIR data further validated this finding. The antimicrobial activity showed the highest inhibitory effect of methanol and aqueous extracts towards different clinical isolates like Acinetobacter baumannii and other pathogens, and the bark extracts showed stronger inhibitory effects than the leaf, which may be correlated to the high saponin content of polar extracts and bark, along with other antimicrobial principles. Consequently, the results proved the efficacious therapy for nosocomial infections and ventilator-associated pneumonia-causing A. baumannii (MIC of 0.078 mg/ml). The documented physicochemical parameters assist in maintaining the efficacy and purity of the drug and also recommend its use as a low-cost source of protein and therapeutic drug after further research.

KEYWORDS
Antimicrobial Activity, Agar Well Diffusion, MIC, Erinocarpus Nimmonii, FTIR, Proximate Analysis, Foam Index, Nutritional Value

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Anitha Puranik , T. C. Taranath , "Assay of Nutritional and Therapeutic Values, Using Physicochemical Parameters and Antimicrobial Activity of Leaf and Bark of Erinocarpus nimmonii Grah. ex Dalz., an Endemic Species," Advances in Pharmacology and Pharmacy, Vol. 11, No. 4, pp. 245 - 257, 2023. DOI: 10.13189/app.2023.110402.

(b). APA Format:
Anitha Puranik , T. C. Taranath (2023). Assay of Nutritional and Therapeutic Values, Using Physicochemical Parameters and Antimicrobial Activity of Leaf and Bark of Erinocarpus nimmonii Grah. ex Dalz., an Endemic Species. Advances in Pharmacology and Pharmacy, 11(4), 245 - 257. DOI: 10.13189/app.2023.110402.