Jensen TS, Baron R, Haanpaa M, et al. A new definition of neuropathic pain. Pain. 2011;152(10):2204–5.

Article  PubMed  Google Scholar 

von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012;73(4):638–52.

Article  Google Scholar 

van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(4):654–62.

Article  PubMed  Google Scholar 

Widerstrom-Noga E. Neuropathic pain and spinal cord injury: phenotypes and pharmacological management. Drugs. 2017;77(9):967–84.

Article  PubMed  Google Scholar 

Malcangio M. Role of the immune system in neuropathic pain. Scand J Pain. 2019;20(1):33–7.

Article  PubMed  Google Scholar 

Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nat Rev Immunol. 2014;14(4):217–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McMahon SB, La Russa F, Bennett DL. Crosstalk between the nociceptive and immune systems in host defence and disease. Nat Rev Neurosci. 2015;16(7):389–402.

Article  CAS  PubMed  Google Scholar 

Ji RR, Chamessian A, Zhang YQ. Pain regulation by non-neuronal cells and inflammation. Science. 2016;354(6312):572–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue K, Tsuda M. Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci. 2018;19(3):138–52.

Article  CAS  PubMed  Google Scholar 

Costigan M, Moss A, Latremoliere A, et al. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009;29(46):14415–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Liu H, Hamel KA, et al. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020;11(1):264.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.

Article  PubMed  PubMed Central  Google Scholar 

Alles SRA, Smith PA. Etiology and pharmacology of neuropathic pain. Pharmacol Rev. 2018;70(2):315–47.

Article  CAS  PubMed  Google Scholar 

Gentles AJ, Newman AM, Liu CL, et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. 2015;21(8):938–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang T, Shi J, Dong Z, et al. Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma. J Hematol Oncol. 2019;12(1):75.

Article  PubMed  PubMed Central  Google Scholar 

Sorge RE, Mapplebeck JC, Rosen S, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015;18(8):1081–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Zhou LJ, Wang J, et al. TNF-alpha differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury. J Neurosci. 2017;37(4):871–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chirila AM, Brown TE, Bishop RA, Bellono NW, Pucci FG, Kauer JA. Long-term potentiation of glycinergic synapses triggered by interleukin 1beta. Proc Natl Acad Sci U S A. 2014;111(22):8263–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeda K, Sawamura S, Sekiyama H, Tamai H, Hanaoka K. Effect of methylprednisolone on neuropathic pain and spinal glial activation in rats. Anesthesiology. 2004;100(5):1249–57.

Article  CAS  PubMed  Google Scholar 

Yin X, Chen S, Eisenbarth SC. Dendritic cell regulation of T helper cells. Annu Rev Immunol. 2021;39:759–90.

Article  CAS  PubMed  Google Scholar 

Jiang BC, Zhang J, Wu B, et al. G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gbetagamma/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion. Pain. 2021;162(5):1434–48.

Article  CAS  PubMed  Google Scholar 

Boyd JT, LoCoco PM, Furr AR, et al. Elevated dietary omega-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions. Nat Metab. 2021;3(6):762–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005;117(3):326–39.

Article  CAS  PubMed  Google Scholar 

Liu Q, Chen W, Fan X, et al. Upregulation of interleukin-6 on Cav3.2 T-type calcium channels in dorsal root ganglion neurons contributes to neuropathic pain in rats with spinal nerve ligation. Exp Neurol. 2019;317:226–43.

Article  CAS  PubMed  Google Scholar 

Jiang SP, Zhang ZD, Kang LM, Wang QH, Zhang L, Chen HP. Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion. Exp Neurol. 2016;275(Pt 1):11–6.

Article  CAS  PubMed  Google Scholar 

Wang L, Yin C, Liu T, et al. Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-kappaB signaling in the spinal cord. J Neuroinflammation. 2020;17(1):83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Wu Z, Hayashi Y, Okada R, Nakanishi H. Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state. J Neurosci. 2014;34(8):3013–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci. 2007;10(11):1361–8.

Article  CAS  PubMed  Google Scholar 

Davoli-Ferreira M, de Lima KA, Fonseca MM, et al. Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain. 2020;161(8):1730–43.

Article  CAS  PubMed  Google Scholar 

Hashimoto D, Chow A, Noizat C, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013;38(4):792–804.

Article  CAS  PubMed  Google Scholar 

Casanova-Acebes M, Dalla E, Leader AM, et al. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021;595(7868):578–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruno K, Woller SA, Miller YI, et al. Targeting toll-like receptor-4 (TLR4)-an emerging therapeutic target for persistent pain states. Pain. 2018;159(10):1908–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papageorgiou IE, Lewen A, Galow LV, et al. TLR4-activated microglia require IFN-gamma to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A. 2016;113(1):212–7.

Article  CAS  PubMed  Google Scholar 

Lees JG, Makker PG, Tonkin RS, et al. Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy. Eur J Cancer. 2017;73:22–9.

Article  CAS  PubMed  Google Scholar 

Niehaus JK, Taylor-Blake B, Loo L, Simon JM, Zylka MJ. Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury. Neuron. 2021;109(8):1274-1282 e1276.