Investigational medications in 9,638 hospitalized patients with severe COVID-19: lessons from the “fail-and-learn” strategy during the first two waves of the pandemic in 2020

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–42.

Article  CAS  PubMed  Google Scholar 

Wilder-Smith A, Freedman DO. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J Travel Med. 2020;27(2):taaa020.

Article  PubMed  Google Scholar 

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020;382(10):929–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stahel PF. How to risk-stratify elective surgery during the COVID-19 pandemic? Patient Saf Surg. 2020;14:8.

Article  PubMed  PubMed Central  Google Scholar 

Docea AO, Tsatsakis A, Albulescu D, et al. A new threat from an old enemy: Re–emergence of coronavirus. Int J Mol Med. 2020;45(6):1631–43.

CAS  PubMed  PubMed Central  Google Scholar 

Khan S, Siddique R, Shereen MA et al. Emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2: Biology and therapeutic options.J. Clin. Microbiol.2020;58(5).

Ma F, Gu T, Zhao S, Liu K, Dong Z. COVID-19 and strategies for its therapeutics. Crit Rev Immunol. 2020;40(6):513–26.

Article  CAS  PubMed  Google Scholar 

Liang C, Tian L, Liu Y, Hui N, Qiao G, Li H, et al. A promising antiviral candidate drug for the COVID-19 pandemic: a mini-review of remdesivir. Eur J Med Chem. 2020;201:112527.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Rensburg R, Pillay-Fuentes Lorente V, Decloedt EH. Current evidence for directed and supportive investigational therapies against COVID-19. Afr J Thorac Crit Care Med. 2020;26(2):10.

PubMed Central  Google Scholar 

McFee RB. COVID-19: therapeutics and interventions currently under consideration. Dis Mon. 2020;66(9):101058.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malik S, Gupta A, Zhong X, Rasmussen TP, Manautou JE, Bahal R. Emerging therapeutic modalities against COVID-19. Pharmaceuticals (Basel). 2020;13(8):188.

Article  CAS  PubMed  Google Scholar 

Elshaboury RH, Monk MM, Bebell LM, et al. Remdesivir use and outcomes during the FDA COVID-19 emergency use authorization period. Ther Adv Infect Dis. 2021;8:20499361211046669.

CAS  PubMed  PubMed Central  Google Scholar 

Bose S, Adapa S, Aeddula NR, et al. Medical management of COVID-19: evidence and experience. J Clin Med Res. 2020;12(6):329–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Putman M, Chock YPE, Tam H, et al. Antirheumatic disease therapies for the treatment of COVID-19: a systematic review and meta-analysis. Arthritis Rheumatol. 2021;73(1):36–47.

Article  CAS  PubMed  Google Scholar 

Mastaglio S, Ruggeri A, Risitano AM, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020;215:108450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kato S, Kurzrock R. Repurposing interleukin-6 inhibitors to combat COVID-19. J Immunother Precis Oncol. 2020;3(2):52–5.

Article  PubMed  PubMed Central  Google Scholar 

Infante M, Ricordi C, Alejandro R, Caprio M, Fabbri A. Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection. Expert Rev Anti Infect Ther. 2021;19(1):5–16.

Article  CAS  PubMed  Google Scholar 

Humeniuk R, Mathias A, Cao H, et al. Safety, tolerability, and pharmacokinetics of remdesivir, an antiviral for treatment of COVID-19, in healthy subjects. Clin Transl Sci. 2020;13(5):896–906.

CAS  PubMed  PubMed Central  Google Scholar 

Sellitto C, Corbi G, Bertini N et al. Effect of remdesivir on mortality rate and clinical status of COVID-19 patients: a systematic review with meta-analysis.J. Chemother.2022:1–14.

Michot JM, Albiges L, Chaput N, et al. Tocilizumab, an anti-IL-6 receptor antibody, to treat COVID-19-related respiratory failure: a case report. Ann Oncol. 2020;31(7):961–4.

Article  PubMed  Google Scholar 

Coomes EA, Haghbayan H. Interleukin-6 in Covid-19: a systematic review and meta-analysis. Rev Med Virol. 2020;30(6):1–9.

Article  CAS  PubMed  Google Scholar 

Aziz M, Haghbin H, Abu Sitta E, et al. Efficacy of tocilizumab in COVID-19: a systematic review and meta-analysis. J Med Virol. 2021;93(3):1620–30.

Article  CAS  PubMed  Google Scholar 

Ayerbe L, Risco-Risco C, Forgnone I, Perez-Pinar M, Ayis S. Azithromycin in patients with COVID-19: a systematic review and meta-analysis. J Antimicrob Chemother. 2022;77(2):303–9.

Article  CAS  PubMed  Google Scholar 

Garcia-Albeniz X, Del Amo J, Polo R, Morales-Asencio JM, Hernan MA. Systematic review and meta-analysis of randomized trials of hydroxychloroquine for the prevention of COVID-19. Eur J Epidemiol. 2022;37(8):789–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eze P, Mezue KN, Nduka CU, Obianyo I, Egbuche O. Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials. Am J Cardiovasc Dis. 2021;11(1):93–107.

CAS  PubMed  PubMed Central  Google Scholar 

Moraes VY, Marra AR, Matos LL, et al. Hydroxychloroquine for treatment of COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials. Einstein (Sao Paulo). 2022;20:eRW0045.

Article  PubMed  Google Scholar 

Henry BM, Vikse J, Benoit S, Favaloro EJ, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahmudpour M, Roozbeh J, Keshavarz M, Farrokhi S, Nabipour I. COVID-19 cytokine storm: the anger of inflammation. Cytokine. 2020;133:155151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stahel PF, Barnum SR. Complement inhibition in coronavirus disease (COVID)-19: a neglected therapeutic option. Front Immunol. 2020;11:1661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afzali B, Noris M, Lambrecht BN, Kemper C. The state of complement in COVID-19. Nat Rev Immunol. 2022;22(2):77–84.

Article  CAS  PubMed  Google Scholar 

Dequin PF, Heming N, Meziani F, et al. Effect of hydrocortisone on 21-day mortality or respiratory support among critically ill patients with COVID-19: a randomized clinical trial. JAMA. 2020;324(13):1298–306.

Article  CAS  PubMed  Google Scholar 

Tomazini BM, Maia IS, Cavalcanti AB, et al. Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX randomized clinical trial. JAMA. 2020;324(13):1307–16.

Article  CAS  PubMed  Google Scholar 

Group RC, Horby P, Lim WS, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384(8):693–704.

Article  Google Scholar 

Climente-Marti M, Ruiz-Millo O, Lopez-Cruz I, et al. Impact of intermediate to high doses of methylprednisolone on mortality rate in patients with COVID-19 pneumonia-induced severe systemic inflammation. Int J Clin Pract. 2021;75(9):e14479.

Article  CAS  PubMed  Google Scholar 

Raju R, V P, Biatris PS. Therapeutic role of corticosteroids in COVID-19: a systematic review of registered clinical trials. Fut J Pharm Sci. 2021;7(1):67.

Article  Google Scholar 

Farzan N, Vahabi S, Foroghi Ghomi SY, et al. Evaluation of invasive ventilation (intubation) prognosis in patients with Covid-19 symptoms. Int J Surg Open. 2020;27:149–53.

Article  PubMed  PubMed Central  Google Scholar 

Mina B, Newton A, Hadda V. Noninvasive ventilation in treatment of respiratory failure-related COVID-19 infection: review of the literature. Can Respir J. 2022;2022:9914081.

Article  PubMed  PubMed Central  Google Scholar 

Barbash IJ, Davis BS, Minturn JS, Kahn JM. Adoption and deadoption of medications to treat hospitalized patients with COVID-19. Crit Care Explor. 2022;4(7):e0727.

Article  PubMed  PubMed Central  Google Scholar 

Horby P, Lim WS, Emberson JR, et al. Dexamethasone in hospitalized patients with Covid-19. N Engl J Med. 2021;384(8):693–704.

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