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Article / Publication Details Abstract

Introduction: To analyze visual and anatomical outcomes after switching to intravitreal brolucizumab therapy in eyes affected by neovascular age-related macular degeneration (nAMD) previously treated with other intravitreal anti-vascular endothelial growth factor (VEGF) agents. Methods: Retrospective study of eyes with nAMD who underwent intravitreal brolucizumab at San Raffaele Hospital (Milan, Italy) or San Rocco Clinical Institute (Ome, Italy) between January 2021 and July 2022. All study eyes had persistent residual retinal fluid after receiving at least 3 intravitreal injections of other anti-VEGF agents prior to switch to brolucizumab. Results: Among 66 eyes from 60 patients (35 males; mean age 76.5 +/-7.4 years) with nAMD, 43 (65.2%) eyes received a complete loading dose of 3 brolucizumab injections, while 15 (22.7%) and 8 (12.1%) eyes were treated with 2 or 1 brolucizumab injections, respectively. The average number of brolucizumab injections was 2.5 during 4.0±2.0 months (mean interval between two injections of 51.2 days). Lower letter gains (

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