Nelson JA, Daniels AU, Dodds WJ. Rectal balloons: complications, causes, and recommendations. Invest Radiol. 1979;14(1):48–59.

• Macygin KMC, Kulstad E, Mokszycki RK, Goldsmith M. Evaluation of the Macy Catheter: a rectal catheter for rapid medication and fluid administration. Expert Rev Med Devices. 2018;15(6):407–14. Details the Macy Catheter components, potential uses, and reviews previous literature published on the Macy Catheter.

Article  CAS  PubMed  Google Scholar 

Honasoge A, Parker B, Wesselhoff K, Lyons N, Kulstad E. First use of a new device for administration of buspirone and acetaminophen to suppress shivering during therapeutic hypothermia. Ther Hypothermia Temp Manag. 2016;6(1):48–51.

Article  PubMed  PubMed Central  Google Scholar 

Paez K, Gregg M, Massion CT, et al. Promoting excellence in symptom management case series: case study: a new intervention for rapid end-of-life symptom control in the home setting. J Hosp Palliat Nurs. 2016;18(6):498–504.

Article  PubMed  Google Scholar 

Honasoge A, Lyons N, Hesse K, Parker B, Mokszycki R, Wesselhoff K, Sweis R, Kulstad EB. A novel approach for the administration of medications and fluids in emergency scenarios and settings. J Vis Exp. 2016;117:54622.

Google Scholar 

Walsh G. Difficult peripheral venous access: recognizing and managing the patient at risk. Journal of the Association for Vascular Access. 2008;13(4):198–203.

Article  Google Scholar 

Xiong Z, Chen H. Interventions to reduce unnecessary central venous catheter use to prevent central-line-associated bloodstream infections in adults: a systematic review. Infect Control Hosp Epidemiol. 2018;39(12):1442–8.

Article  PubMed  Google Scholar 

Chopra V, Flanders SA, Saint S, et al. The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC): results from a multispecialty panel using the RAND/UCLA appropriateness method. Ann Intern Med. 2015;163(6):S1–40.

Article  PubMed  Google Scholar 

Barr J, Gulrajani NB, Hurst A, Pappas T. Bottoms up: a history of rectal nutrition from 1870 to 1920, Annals of Surgery Open. 2021;2(1).

Doyle D. Per rectum: a history of enemata. J R Coll Physicians Edinb. 2005;35:367–70.

CAS  PubMed  Google Scholar 

Majno G. The healing hand: man and wound in the Ancient world. Boston: Harvard University Press; 1975.

Google Scholar 

Agnew DH. The principles and practice of surgery: being a treatise on surgical disease and injuries. 2nd ed. Lippincott, 1889.

Pappas TN, Joharifard S. Did James A. Garfield die of cholecystitis? Revisiting the autopsy of the 20th president of the United States. Am J Surg. 2013;206:613–18.

Bliss DW. Feeding per rectum as illustrated in the case of the Late President Garfield and Others. n.p., 1882.

Rixey P, Mann M, Mynter H, et al. The official report on the case of President McKinley JAMA. 1901;37:1029–36.

Google Scholar 

Brown WL. An inquiry into the value of rectal feeding. Proc R Soc Med. 1911;4 Ther Pharmacol. Sect 63–76.

Moore FC. Rectal feeding: a review. Practitioner. 1907;79:668–77.

Google Scholar 

Murphy JB. Proctoclysis in the treatment of peritonitis. JAMA. 1909;52:1248–50.

Article  Google Scholar 

Murphy JB. Perforative peritonitis; general, free, suppurative. Surg Gynecol Obstetrics 1908;VI:565–98.

Robertson OH, Bock AV. Blood volume in wounded soldiers: II. The use of forced fluids by the alimentary tract in the restoration of blood volume after hemorrhage. J Expe Med. 1919;29(2):155–71.

• Wang H, Higgins T, Robinson R. Proctoclysis. In: Reichman EF. eds. Reichman’s emergency medicine procedures, 3e. McGraw Hill; 2018. Accessed May 20, 2022. Details proctoclysis in the emergency setting and the anatomy and physiology of proctoclysis.

Lyons N, Nejak D, Lomotan N, Mokszycki R, Jamieson S, McDowell M, Kulstad E. An alternative for rapid administration of medication and fluids in the emergency setting using a novel device. Am J Emerg Med. 2015;33(8):1113. e5–6. https://doi.org/10.1016/j.ajem.2015.01.028. Epub 2015 Jan 21.

Macygin KMC, Lee J, Lam A, Carlstedt R, Macy B. Safe and effective administration of lactulose retention enema in the ED using specialized rectal medication administration catheter. Am J Emerg Med. 2018;36(3):521–2.

Article  PubMed  Google Scholar 

• Pavlu D, DeMarco K, Sobrino-Bonilla Y. Field notes from the frontline of a COVID-19 outbreak: dyspnea management for hospitalized patients at end-of-life. J Hosp Palliat Nurs. 2021;23(2):128–34. Report of a hospital palliative care programs’ use of the Macy Catheter for medication administration to dying COVID patients due to severe parenteral drug shortages.

Article  PubMed  Google Scholar 

Latuga NM, Gordon M, Farwell P, Farrell MO. A cost and quality analysis of utilizing a rectal catheter for Medication administration in end-of-life symptom management. J Pain Palliat Care Pharmacother. 2018;32(2–3):63–70.

Lam Y, Lam A, Macy B. Pharmacokinetics of phenobarbital in micro- enema via Macy Catheter versus suppository. J Pain Symptom Manage. 2016;51(6):994–1001.

Article  PubMed  Google Scholar 

Quinlin LM, Schmitz WG, Jefferson MD. Macy Catheter: integration and evaluation in a hospice setting to provide symptom relief during end-of-life care. Clin J Oncol Nurs. 2020;24(6):689–93.

Article  PubMed  Google Scholar 

Parker R. Decreasing hospital transfers in skilled nursing: utilizing a rectal administration catheter for fluid and medication delivery. The Director: Official Journal of the National Association of Directors of Nursing Administration in Long Term Care. 2020;28(1):26–7.

Google Scholar 

Trout HH. Proctoclysis: some clinical and experimental observations. JAMA. 1912;LVIII(18):1352–4.

Bruera E, Pruvost M, Schoeller T, Montejo G, Watanabe S. Proctoclysis for hydration of terminally ill cancer patients. J Pain Symptom Manage. 1998;15:216–9.

Article  CAS  PubMed  Google Scholar 

Davis MP, Walsh D, LeGrand SB, Naughton M. Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions. Support Care Cancer. 2002;10(2):117–38.

Article  PubMed  Google Scholar 

Moolenaar F, Schoonen AJ, Everts AM, Huizinga T. Biopharmaceutics of rectal administration of drugs in man. Pharm Weekbl. 2005;1:689–94.

Article  Google Scholar 

DeBoer, AG, Moolenaar F, de Leede LG, Breimer DD., Rectal drug administration: clinical pharmacokinetic considerations. Clin Pharmacokinet. 1982;7(4):285–311.

De Boer AG, De Leede LGJ. Breimer DD Drug absorption by sublingual and rectal routes. Br J Anaesth. 1984;56:69–82.

Article  PubMed  Google Scholar 

De Conno F, Ripamonti C, Saita L, MacEachern T, Hanson J, Bruera E. Role of rectal route in treating cancer pain: a randomized crossover clinical trial of oral versus rectal morphine administration in opioid-naive cancer patients with pain. J Clin Oncol. 1995;13(4):1004–8.

Article  PubMed  Google Scholar 

Moolenaar F, Yska JP, Visser J, et al. Drastic improvement in the rectal absorption profile of morphine in man. Eur J Clin Pharmacol. 1985;29:119–21.

Article  CAS  PubMed  Google Scholar 

van Hoogdalem E, de Boer AG, Breimer DD. Pharmacokinetics of rectal drug administration. I Clin Pharmacokinet. 1991;21:11–26.

Article  PubMed  Google Scholar 

Leow KP, Smith MT, Watt JA, Williams BE, Cramond T. Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration. Ther Drug Monit. 1992;14(6):479–84.

Article  CAS  PubMed  Google Scholar 

Leow KP, Cramond T, Smith MT. Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. Anesth Analg. 1995;80(2):296–302.

CAS  PubMed  Google Scholar 

Dale O, Sheffels P, Kharasch ED. Bioavailabilities of rectal and oral methadone in healthy subjects. Br J Clin Pharmacol. 2004;58(2):156–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ripamonti C, Zecca E, Brunelli C, Rizzio E, Saita L, Lodi F, De Conno F. Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. Ann Oncol. 1995;6(8):841–3.

Moolenaar F, Fiets G, Visser J, Meijer DKF. Preliminary study on the absorption profile after rectal and oral administration of methadone in human volunteers. Pharm Weekbl. 1984;6(6):237–40.

Article  CAS  Google Scholar 

Parab PV, Ritschel WA, Coyle DE, Gregg RV, Denson DD. Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects. Biopharm Drug Dispos. 1988;9(2):187–99.

Article  CAS  PubMed  Google Scholar 

Ritschel WA, Parab PV, Denson DD, Coyle DE, Gregg RV. Absolute bioavailability of hydromorphone after peroral and rectal administration in humans: saliva/plasma ratio and clinical effects. J Clin Pharmacol. 1987;27(9):647–53.

Article  CAS  PubMed  Google Scholar 

deBoer AG, at al. Rectal bioavailability of lidocaine in man: partial avoidance of "first pass" metabolism Clin Pharmacol Ther. 1979;26(6):701–9.

Yanagihara Y, Ohtani M, Kariya S, Uchino K, Hiraishi T, Ashizawa N, Aoyama T, Yamamura Y, Yamada Y, Iga T. Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers. Biopharm Drug Dispos. 2003;24(1):37–43.

Article  CAS  PubMed  Google Scholar 

EL Parrott Salicylate absorption from rectal suppositories.  J Pharm Science 1971;60:867–72.

Jensen KM, Grenabo L. Bioavailability of indomethacin after intramuscular injection and rectal administration of solution and suppositories. Acta Pharmacol Toxicol (Copenh). 1985;57(5):322–7.

Article  CAS  PubMed  Google Scholar 

Eller MG, Wright C 3rd, Della-Coletta AA. Absorption kinetics of rectally and orally administered ibuprofen. Biopharm Drug Dispos. 1989;10(3):269–78.

Article  CAS  PubMed  Google Scholar 

Ishizaki T, Sasaki T, Suganuma T, Horai Y, Chiba K, Watanabe M, Asuke W, Hoshi H. Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol. 1980;18(5):407–14.

Article  CAS  PubMed  Google Scholar 

Desager JP, Vanderbist M, Harvengt C. Naproxen plasma levels in volunteers after single-dose administration by oral and rectal routes. J Clin Pharmacol. 1976;16(4):189–93.

Article  CAS  PubMed  Google Scholar 

Moolenaar F, Olthof L, Huizinga T. Biopharmaceutics of rectal administration of drugs in man. Pharmaceutisch Weekblad. 1979;1:201–6.

Letizia M, Norton E. Successful management of malignant bowel obstruction. J Hospice Palliative Nursing. 2003;5(3):152–8.

Chaumeil JC, Khoury JM, Zuber M, Courteille F, Piraube C, Gard C. Formulation of suppositories containing imipramine and clomipramine chlorhydrates. Drug Dev Ind Pharm. 1988;14:2225–39.

Article  CAS  Google Scholar 

Storey P, Trumble M. Rectal doxepin and carbamazepine therapy in patients with cancer. N Engl J Med. 1992;327:1318–9.

Article  CAS  PubMed  Google Scholar 

Adams S. Amitriptyline suppositories. N Engl J Med. 1982;306:996.

Article  CAS