*Irset (Institut de Recherche en Santé, Environnement et Travail)—UMR S 1085, EHESP, Inserm, CHU Rennes;

†INSERM, Centre d’Investigation Clinique;

‡Laboratoire de pharmacologie biologique, Centre Hospitalier Universitaire de Rennes;

§Service de chirurgie cardio-thoracique et vasculaire, Centre Hospitalier Universitaire de Rennes;

¶Laboratoire d'hématologie, Centre Hospitalier Universitaire de Rennes;

‖Université de Rennes, Établissement Français du Sang (EFS) de Bretagne, Inserm, MICMAC-UMR_S1236;

**Laboratoire d'anatomie et cytologie pathologiques, Centre Hospitalier Universitaire de Rennes;

††Centre de Ressources Biologiques (CRB) Santé de Rennes BB-0033-00056, Centre Hospitalier Universitaire de Rennes;

‡‡Laboratoire Traitement du Signal et de l'Image (LTSI) unité mixte 1099 INSERM; and

§§FHU SUPORT, Rennes, France.

Correspondence: Gwendal Coste, PhD, Laboratoire de pharmacologie biologique, Pôle biologie, CHU de Rennes, 2 rue Henri Le Guilloux, 35033 Rennes CEDEX 9, France (e-mail: [email protected]).

G. Coste's PhD has been partly funded by Astellas Pharma. Florian Lemaitre has been invited to participation in congresses by Chiesi and Sandoz. The team received research funds (paid to institution) from Sandoz, Chiesi and Astellas Pharma.

Author contributions based on CRediT classification: Gwendal Coste: data curation, formal analysis, investigation, methodology, validation, visualization, writing—original draft, writing—review and editing; Céline Chabanne: resources, writing—review and editing; Camille Tron: conceptualization; formal analysis, investigation, methodology, visualization, writing—original draft, writing—review and editing; Bernard Lelong: resources; Marie-Clémence Verdier: writing—review and editing; Mikael Roussel: Methodology, supervision; François Le Gall: investigation, resources; Bruno Turlin: investigation, resources, writing—review and editing; Mireille Desille-Dugast: supervision, writing—review and editing; Erwan Flécher: resources, supervision, writing—review and editing; Bruno Laviolle: funding acquisition, supervision; Florian Lemaitre: conceptualization, formal analysis, funding acquisition, methodology, project administration, supervision, visualization, writing—original draft, writing—review and editing. All authors have read and agreed to this version of the manuscript.

The authors declare no conflict of interest.

This study was conducted in accordance with the revised Declaration of Helsinki. All persons implicated in the research provided informed consent.

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