Stereotactic and Functional Neurosurgery

Blitz S.E.a· Torre M.b· Chua M.M.J.c· Christie S.L.c· McDannold N.J.d· Cosgrove G.R.c

Author affiliations

aHarvard Medical School, Boston, MA, USA
bDepartment of Pathology, Brigham and Women’s Hospital, Boston, MA, USA
cDepartment of Neurosurgery, Brigham and Women’s Hospital, Boston, MA, USA
dDepartment of Radiology, Brigham and Women’s Hospital, Boston, MA, USA

Stereotact Funct Neurosurg

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Article / Publication Details

First-Page Preview

Received: August 13, 2022
Accepted: September 23, 2022
Published online: January 25, 2023

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

Abstract

Magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) is a rapidly developing technique used for tremor relief in tremor-predominant Parkinson’s disease (PD) and essential tremor that has demonstrated successful results. Here, we describe the neuropathological findings in a woman who died from a fall 10 days after successful MRgFUS for tremor-predominant PD. Histological analysis demonstrates the characteristic early postoperative MRI findings including 3 distinct zones on T2-weighted imaging: (1) a hypointense core, (2) a hyperintense region with hypointense rim, and (3) a slightly hyperintense, poorly marginated surrounding area. Histopathological analyses also demonstrate the suspected cellular processes composing each of these regions including central hemorrhagic necrosis with surrounding cytotoxic edema and a rim of mostly unaffected vasogenic edema with some reactive and reparative processes. Overall, this case demonstrates the correlation of postoperative imaging findings with the subacute neuropathological findings after MRgFUS for PD.

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First-Page Preview

Received: August 13, 2022
Accepted: September 23, 2022
Published online: January 25, 2023

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: https://www.karger.com/SFN

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