Use of Machine Learning and Lay Care Coaches to Increase Advance Care Planning Conversations for Patients With Metastatic Cancer

Conception and design: Michael F. Gensheimer, Manali I. Patel, Winifred Teuteberg, Briththa Seevaratnam, Jennifer Hansen, Jan DeNofrio, Divya Parikh, Heather Wakelee, Kavitha Ramchandran

Financial support: Briththa Seevaratnam, Kavitha Ramchandran

Administrative support: Rachel Hildebrand, Briththa Seevaratnam, Jennifer Hansen, Kaidi Moore, Kavitha Ramchandran

Provision of study materials or patients: Manali I. Patel, Rachel Hildebrand, Kaidi Moore, Sandhya Srinivas, Heather Wakelee, Kavitha Ramchandran

Collection and assembly of data: Michael F. Gensheimer, Divya Gupta, Manali I. Patel, Touran Fardeen, Rachel Hildebrand, Mary Khay Asuncion, Nina Alves, Brian Rogers, Jennifer Hansen, Joel Neal, Alice C. Fan, Kaidi Moore, Shann Ruiz, Connie Li, Ali Raza Khaki, Joanne Chien, Tiffany Brown, Alison Holmes Tisch, Sandhya Srinivas, Heather Wakelee, Howard Lee, Kavitha Ramchandran

Data analysis and interpretation: Michael F. Gensheimer, Divya Gupta, Manali I. Patel, Rachel Hildebrand, Mary Khay Asuncion, Nina Alves, Nigam H. Shah, Joel Neal, Alice C. Fan, Judy Pagtama, Millie Das, Sandhya Srinivas, Mohana Roy, Heather Wakelee, Nathaniel J. Myall, Jane Huang, Sumit Shah, Kavitha Ramchandran

Manuscript writing: All authors

Final approval of manuscript: All authors

Accountable for all aspects of the work: All authors

AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST

Use of Machine Learning and Lay Care Coaches to Increase Advance Care Planning Conversations for Patients With Metastatic Cancer

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/op/authors/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Michael F. Gensheimer

Employment: Roche/Genentech (I)

Stock and Other Ownership Interests: Roche/Genentech

Research Funding: Varian Medical Systems

Open Payments Link: https://openpaymentsdata.cms.gov/physician/431774

Nigam H. Shah

Leadership: Prealize, Atropos

Consulting or Advisory Role: Curai

Research Funding: Google (Inst)

Joel Neal

Honoraria: CME Matters, Clinical Care Options, Research to Practice, Medscape, Biomedical Learning Institute, Peerview, Prime Oncology, Projects in Knowledge, Rockpointe CME, MJH Life Sciences, Medical Educator Consortium, HMP Education

Consulting or Advisory Role: AstraZeneca, Genentech/Roche, Exelixis, Jounce Therapeutics, Takeda, Lilly, Calithera Biosciences, Amgen, Iovance Biotherapeutics, Blueprint Pharmaceuticals, Regeneron, Natera, Sanofi/Regeneron, D2G Oncology, Surface Oncology, Turning Point Therapeutics, Mirati Therapeutics, Gilead Sciences

Research Funding: Genentech/Roche (Inst), Merck (Inst), Novartis (Inst), Boehringer Ingelheim (Inst), Exelixis (Inst), Nektar (Inst), Takeda (Inst), Adaptimmune (Inst), GlaxoSmithKline (Inst), Janssen (Inst), AbbVie (Inst)

Patents, Royalties, Other Intellectual Property: UpToDate—Royalties

Alice C. Fan

Employment: Silverado Hospice, BeiGene

Stock and Other Ownership Interests: Molecular Decisions, Antelope Valley Care Center

Consulting or Advisory Role: Verily

Research Funding: Earli (Inst), Filtricine (Inst), MagARRAY (Inst), Calithera Biosciences (Inst)

Patents, Royalties, Other Intellectual Property: Stanford Patent has been licensed

Ali Raza Khaki

Honoraria: OncLive/MJH Life Sciences

Uncompensated Relationships: Seattle Genetics/Astellas

Joanne Chien

Honoraria: Janssen Oncology, Seattle Genetics, Coherus Biosciences

Consulting or Advisory Role: Coherus Biosciences, Seattle Genetics, Janssen Oncology

Travel, Accommodations, Expenses: Coherus Biosciences

Millie Das

Honoraria: Plexus

Consulting or Advisory Role: Jazz Pharmaceuticals, AstraZeneca, BeiGene, Sanofi

Research Funding: Novartis, Verily, Varian Medical Systems, AbbVie, United Therapeutics, Cellsight Technologies

Sandhya Srinivas

Consulting or Advisory Role: Eisai, Bayer, Bristol Myers Squibb, Merck, AstraZeneca, Seattle Genetics, Janssen Oncology, Novartis

Research Funding: Bristol Myers Squibb (Inst), Genentech (Inst), Merck (Inst), Exelixis (Inst), Eisai (Inst), Bayer (Inst), AstraZeneca (Inst), Seattle Genetics/Astellas (Inst)

Other Relationship: Pfizer

Mohana Roy

Speakers' Bureau: MJH Life Sciences

Research Funding: Varian Medical Systems (Inst)

Heather Wakelee

Consulting or Advisory Role: AstraZeneca, Mirati Therapeutics, Blueprint Medicines

Research Funding: Genentech/Roche (Inst), Celgene (Inst), AstraZeneca/MedImmune (Inst), Novartis (Inst), Clovis Oncology (Inst), Xcovery (Inst), Bristol Myers Squibb (Inst), ACEA Biosciences (Inst), Arrys Therapeutics (Inst), Merck (Inst), Seattle Genetics (Inst), Helsinn Therapeutics (Inst)

Uncompensated Relationships: Merck, Genentech/Roche

Nathaniel J. Myall

Honoraria: Patient Power

Jane Huang

Employment: Beigene, Prelude Therapeutics

Leadership: 858 Therapeutics, Protara Therapeutics, Prelude Therapeutics, BeiGene

Stock and Other Ownership Interests: Protara Therapeutics, BeiGene, 858 Therapeutics, Prelude Therapeutics

Consulting or Advisory Role: BeiGene

Sumit Shah

Honoraria: Janssen

Consulting or Advisory Role: Natera, Grand Rounds/Included Health

Research Funding: Genentech

Howard Lee

Employment: Silverado Hospice

Leadership: AV Supportive Care & Hospice

Stock and Other Ownership Interests: AV Supportive Care & Hospice

Consulting or Advisory Role: BeiGene

Patents, Royalties, Other Intellectual Property: Stanford patent licensed

Kavitha Ramchandran

Consulting or Advisory Role: Drishti, GroupWell, Varian Medical Systems

No other potential conflicts of interest were reported.

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