The origins of type 2 diabetes medications

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Interview with John Eng. Dr John Eng’s research found that the saliva of the Gila Monster contains a hormone that treats diabetes better than any other medicine. Diabetes in Control, 2007. https://www.diabetesincontrol.com/dr-john-engs-research-found-that-the-saliva-of-the-gila-monster-contains-a-hormone-that-treats-diabetes-better-than-any-other-medicine/ Accessed 23 October 2022

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De Block C, Bailey C, Wysham C, Hemmingway A, Allen SE, Peleshok J. Tirzepatide for the treatment of adults with type 2 diabetes: An endocrine perspective. Diabetes Obes Metab 2022; https://doi.org/10.1111/dom.14831. Online ahead of print.

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Meng W, Ellsworth BA, Nirschl AA, et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem 2008;51:1145–9. https://doi.org/10.1021/jm701272q

Tahrani AA, Barnett AH, Bailey CJ. SGLT inhibitors in management of diabetes. Lancet Diabetes Endocrinol 2013;1:140–51. https://doi.org/10.1016/S2213-8587(13)70050-0

McGuire DK, Shih WJ, Cosentino F, et al. Association of SGLT2 inhibitors with cardiovascular and kidney outcomes in patients with type 2 diabetes: a meta- analysis. JAMA Cardiol 2021;6:148-58. https://doi.org/10.1001/jamacardio.2020.4511

Davies MJ, Aroda VR, Collins BS, et al. Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2022;65:1925–66. https://doi.org/10.1007/s00125-022-05787-2

Day C, Bailey CJ. The hypocaloric diet in type 2 diabetes - déjà vu. Br J Diab Vasc Dis 2012;12:48-52. https://doi.org/10.1177/1474651412437503

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