Stomach and Duodenum: Research Article

Milivojevic V. · Babic I. · Kekic D. · Rankovic I. · Sagdati S. · Panic N. · Sekulic Spasic I. · Krstic M. · Milosavljevic T. · Moreira L. · Perez Nyssen O. · Mégraud F. · O' Morain C. · Gisbert J.P.

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Article / Publication Details Abstract

Background: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Treatment effectiveness remains a subject of debate considering bacterial antimicrobial resistance. Our aim was to analyse the diagnostic methods and eradication treatments for H. pylori infection in Serbia. Methods: An observational multicentre prospective study was conducted in Serbia, as part of the European Registry on H. pylori Management (Hp-EuReg). Demographics, treatment indication, diagnostic methods, previous eradication attempts and treatment were collected at AEG-REDCap e-CRF. Modified intention-to-treat (mITT) and per protocol (PP) effectiveness analyses were performed. Safety, compliance and bacterial antimicrobial resistance rates were reported. Data was quality checked. Results: Overall 283 patients were included, with a mean age of 55±15 years. Dyspepsia (n=214, 77%) was the most frequent treatment indication, and histology (n=144, 51%) was the most used diagnostic method. Overall eradication rate was 95% (PP) and 94% (mITT). Most prevalent first-line therapy was quadruple PPI+clarithromycin+amoxicillin+metronidazole, with a 96% effectiveness (p

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