Correspondence to: Ernst Mayerhofer, MD, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114. Email

E-mail Address: [email protected]

https://orcid.org/0000-0001-8902-4209

Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA (Y.C., E.M., L.P., J.R., C.D.A.).

The Broad Institute of Harvard and MIT, Cambridge (Y.C., E.M., L.P., P.B., J.R., C.D.A.).

Department of Neurology and Neurophysiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany (E.M., A.H.).