Hypertension in Women: Impact of Contraception, Fertility, and Hormone Treatment

Tsao CW, Aday AW, Almarzooq ZI, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart Disease and Stroke Statistics-2022 Update: A Report from the American Heart Association. Circulation. 2022;145(8):e153–639. This annual report summarizes the most up to date statistics related to heart disease, stroke, and cardiovascular risk factors including hypertension.

Gholizadeh L, Davidson P. More similarities than differences: an international comparison of CVD mortality and risk factors in women. Health Care Women Int. 2008;29:3–22.

PubMed  Google Scholar 

Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Dennison C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension. 2018;71(19):e13-115.

CAS  PubMed  Google Scholar 

Muiesan ML, Salvetti M, Rosei CA, Paini A. Gender differences in antihypertensive treatment: myths or legends? High Blood Press Cardiovasc Prev. 2016;23:105–13.

CAS  PubMed  Google Scholar 

Barton M, Meyer MR. Postmenopausal hypertension: mechanism and therapy. Hypertension. 2009;54:11–8.

CAS  PubMed  Google Scholar 

Carson AP, Howard G, Burke GL, Shea S, Levitan EB, Muntner P. Ethnic differences in hypertension incidence among middle-aged and older adults: the mutli-ethnic study of atherosclerosis. Hypertension. 2011;57(6):1101–7.

CAS  PubMed  Google Scholar 

Beckie TM. Ethnic and racial disparities in hypertension management among women. Semin Perinatol. 2017;41(5):278–86.

PubMed  Google Scholar 

Hilliard LM, Sampson AK, Brown RD, Denton KM. The “his and hers” of the renin-angiotensin system. Curr Hypertens Rep. 2012;15:71–9.

Google Scholar 

Fardoun M, Dehaini H, Shaito A, Mesmar J, El-Yazbi A, Badran A, Beydoun E, Eid AH. The hypertensive potential of estrogen: an untold story. Vascul Pharmacol. 2020;124:106600.

CAS  PubMed  Google Scholar 

Subramanian M, Balasubramanian P, Garver H, Northcott C, Zhao H, Haywood JR, Fink GD, MohanKumar SMJ, MohanJumar PS. Chronic estradiol-17B exposure increases superoxide production in the rostral ventrolateral medulla and causes hypertension: reversal by resveratrol. Am J Phys Regul Integr Comp Phys. 2011;300(6):1560–8.

Google Scholar 

Catt KJ, Zimmet PZ, Cain MD, Cran E, Best JB, Coghlan JP. Angiotension II blood-levels in human hypertension. Lancet. 1971;297(7697):459–64.

Google Scholar 

White RE, Han G, Dimitropoulou C, Zhu S, Miyake K, Fulton D, Dave S, Barman SA. Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle. Am J Physiol Heart Cir Physiol. 2005;289(4):H1468-1475.

CAS  Google Scholar 

Wang Y, Wu Z, Thorin E, Tremblay J, Lavoie JL, Luo H, Peng J, Qi S, Wu T, Chen F, Shen J, Hu S, Wu J. Estrogen and testosterone in concert with ENB3 regulate vascular smooth muscle cell contractility and blood pressure. Am J Physiol Heart Cir Physiol. 2016;310:H861-872.

Google Scholar 

Ashraf MS, Vongpatanasin W. Estrogen and hypertension. Curr Hypertens Rep. 2006;8(5):368–76.

CAS  PubMed  Google Scholar 

Dubey RK, Oparil S, Imthurn B, Jackson EK. Sex hormones and hypertension. Cardiovasc Research. 2002;53(3):688–708.

CAS  Google Scholar 

Harvey PJ, Molloy D, Upton J, Wing LM. Dose response effect of cyclical medroxyprogesterone on blood pressure in postmenopausal women. J Hum Hypertens. 2001;15:313–21.

CAS  PubMed  Google Scholar 

Lemos de Morais T, Giribela C, Nisenbaum MG, Guerra G, Mello N, Baracat E, Consolim-Colombo FM. Effects of a contraceptive containing drospirenone and ethinylestradiol on blood pressure, metabolic profile, and neurohumoral axis in hypertensive women at reproductive age. Eur J Obstet Gynecol Reprod Biol. 2014;182:113–7.

Google Scholar 

Zhao X, Zhang XF, Zhao Y, Lin X, Li NY, Paudel G, Wang QY, Zhang XW, Li XL, Yu J. Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systematic review and meta-analysis. Gynecol Endocrinol. 2016;32(9):685–9.

CAS  PubMed  Google Scholar 

Caulin-Glader T, Garcia-Cardena G, Sarrel P, Sessa WC, Bender JR. 17B-Estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997;81:885–92.

Google Scholar 

Teal S, Edelman A. Contraception selection, effectiveness, and adverse effects: a review. JAMA. 2021;326:2507–18. This recent review describes various contraception options and the adverse effects associated with them.

Daniels K, Abma J. Current contraceptive status among women aged 15–49: United States, 2017–2019. NCHS Data Brief, no 388. Hyattsville, MD: National Center for Health Statistics. 2020. Report No.: 388.

Fuchs N, Düsterberg B, Weber-Diehl F, Mühe B. The effect on blood pressure of a monophasic oral contraceptive containing ethinylestradiol and gestodene. Contraception. 1995;51:335–9.

CAS  PubMed  Google Scholar 

Woods JW 1988 Oral contraceptives and hypertension. Hypertens Dallas Tex 1979 1988;11:II11–15.

Perol S, Hugon-Rodin J, Plu-Bureau G. Hypertension and contraception. Presse Medicale Paris Fr. 1983;2019(48):1269–83.

Google Scholar 

Oelkers W, Blümel A, Schöneshöfer M, Schwartz U, Hammerstein J. Effects of ethinylestradiol on the renin-angiotensin-aldosterone-system and on plasma transcortin in women and men. J Clin Endocrinol Metab. 1976;43:1036–40.

CAS  PubMed  Google Scholar 

Goldhaber SZ, Hennekens CH, Spark RF, Evans DA, Rosner B, Taylor JO, et al. Plasma renin substrate, renin activity, and aldosterone levels in a sample of oral contraceptive users from a community survey. Am Heart J. 1984;107:119–22.

CAS  PubMed  Google Scholar 

Gordon MS, Chin WW, Shupnik MA. Regulation of angiotensinogen gene expression by estrogen. J Hypertens. 1992;10:361–6.

CAS  PubMed  Google Scholar 

Kang AK, Duncan JA, Cattran DC, Floras JS, Lai V, Scholey JW, et al. Effect of oral contraceptives on the renin angiotensin system and renal function. Am J Physiol Regul Integr Comp Physiol. 2001;280:R807-813.

CAS  PubMed  Google Scholar 

Hollenberg NK, Williams GH, Burger B, Chenitz W, Hoosmand I, Adams DF. Renal blood flow and its response to angiotensin II. An interaction between oral contraceptive agents, sodium intake, and the renin-angiotensin system in healthy young women. Circ Res. 1976;38:35–40.

CAS  PubMed  Google Scholar 

Shufelt C, LeVee A. Hormonal contraception in women with hypertension. JAMA. 2020;324:1451–2.

PubMed  PubMed Central  Google Scholar 

Fisch IR, Frank J. Oral contraceptives and blood pressure. JAMA. 1977;237:2499–503.

CAS  PubMed  Google Scholar 

Cardoso F, Polonia J, Santos A, Silva-Carvalho J, Ferreira-de-Almeida J. Low-dose oral contraceptives and 24-hour ambulatory blood pressure. Int J Gynaecol Obstet. 1997;59:237–43.

CAS  PubMed  Google Scholar 

Narkiewicz K, Graniero GR, D”este D, Mattarei M, Zonzin P, Palatini P. Ambulatory blood pressure in mild hypertensive women taking oral contraceptives. A case-control study Am J Hypertens. 1995;8:249–53.

CAS  PubMed  Google Scholar 

Liu H, Yao J, Wang W, Zhang D. Association between duration of oral contraceptive use and risk of hypertension: a meta-analysis. J Clin Hypertens Greenwich Conn. 2017;19:1032–41.

CAS  Google Scholar 

Chasan-Taber L, Willett WC, Manson JE, Spiegelman D, Hunter DJ, Curhan G, et al. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation. 1996;94:483–9.

CAS  PubMed  Google Scholar 

Curtis KM. U.S. Medical eligibility criteria for contraceptive use, 2016. MMWR Recomm Rep [Internet]. 2016 [cited 2022 Jan 11];65. Available from: https://www.cdc.gov/mmwr/volumes/65/rr/rr6503a1.htm

Dong W, Colhoun HM, Poulter NR. Blood pressure in women using oral contraceptives: results from the Health Survey for England 1994. J Hypertens. 1997;15:1063–8.

CAS  PubMed  Google Scholar 

Curtis KM, Mohllajee AP, Martins SL, Peterson HB. Combined oral contraceptive use among women with hypertension: a systematic review. Contraception. 2006;73:179–88.

CAS  PubMed  Google Scholar 

Lubianca JN, Moreira LB, Gus M, Fuchs FD. Stopping oral contraceptives: an effective blood pressure-lowering intervention in women with hypertension. J Hum Hypertens. 2005;19:451–5.

CAS  PubMed  Google Scholar 

Trussell J. Contraceptive failure in the United States. Contraception. 2011;83:397–404.

PubMed  PubMed Central  Google Scholar 

Britton LE, Alspaugh A, Greene MZ, McLemore MR. CE: an evidence-based update on contraception. AJN Am J Nurs. 2020;120:22–33.

PubMed  Google Scholar 

Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC. Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ. 2014;348:g2301.

PubMed  PubMed Central  Google Scholar 

Rosenthal T, Oparil S. The effect of antihypertensive drugs on the fetus. J Hum Hypertens. 2002;16:293–8.

CAS  PubMed  Google Scholar 

Kovell LC, Meyerovitz CV, Skaritanov E, Ayturk D, Person SD, Kumaraswami T, et al. 2022 Hypertension and contraceptive use among women of child-bearing age in the United States from 2001 to. J Hypertens. 2018;40:776–84. This study highlights that women with hypertension are often not using contraception, and among those that are using contraception, they are more likely to use estrogen containing, blood pressure increasing contraception.

Infertility | Reproductive Health | CDC. Published March 3, 2022. Accessed April 10, 2022. https://www.cdc.gov/reproductivehealth/infertility/index.htm

Hong X, Zhao J, Huang K, et al. Preconception blood pressure and time to pregnancy among couples attempting to conceive their first pregnancy. Am J Obstet Gynecol. 2019;221(5):470.e1-470.e10.

Google Scholar 

Nobles CJ, Mendola P, Mumford SL, et al. 2018 Preconception blood pressure levels and reproductive outcomes in a prospective cohort of women attempting pregnancy. Hypertens Dallas Tex. 1979;71(5):904–10.

Google Scholar 

Pang L, Wei Z, Li O, et al. An increase in vascular endothelial growth factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion. PLoS ONE. 2013;8(9):e75759.

CAS  PubMed  PubMed Central  Google Scholar 

D’Ippolito S, Tersigni C, Marana R, et al. Inflammosome in the human endometrium: further step in the evaluation of the “maternal side.” Fertil Steril. 2016;105(1):111-118.e1-4.

PubMed  Google Scholar 

ART Success Rates | CDC. Published March 21, 2022. Accessed May 10, 2022. https://www.cdc.gov/art/artdata/index.html

Dayan N, Lanes A, Walker MC, Spitzer KA, Laskin CA. Effect of chronic hypertension on assisted pregnancy outcomes: a population-based study in Ontario. Canada Fertil Steril. 2016;105(4):1003–9.

PubMed  Google Scholar 

Chih HJ, Elias FTS, Gaudet L, Velez MP. Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses. BMC Pregnancy Childbirth. 2021;21(1):449.

PubMed  PubMed Central  Google Scholar 

Moreno-Sepulveda J, Espinós JJ, Checa MA. Lower risk of adverse perinatal outcomes in natural versus artificial frozen-thawed embryo transfer cycles: a systematic review and meta-analysis. Reprod Biomed Online. 2021;42(6):1131–45.

PubMed 

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