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Annals of Nutrition and Metabolism
Human Nutrition: Research Article
Wu S. · Feng P. · Li W. · Zhuo S. · Lu W. · Chen P. · Sui Y. · Fang S. · Yang Z. · Ye Y.
Background: Emerging evidence suggests that dietary one-carbon metabolism-related B-vitamins are associated with the reduced risk of cardiovascular disease (CVD) in general populations. However, only a few studies have assessed their associations in patients with type 2 diabetes (T2D). Objective: This study aims to assess the associations between the intake of three one-carbon metabolism-related B-vitamins (folate, vitamin B6 and vitamin B12) and CVD risk in Chinese patients with T2D. Methods: A hospital-based case–control study of 419 patients with T2D and newly diagnosed CVD and 419 age- (±5 years) and sex-matched T2D-only controls was carried out in China. A validated 79-item semiquantitative food-frequency questionnaire administered in face-to-face interviews was used to measure dietary B-vitamin intake. Conditional logistic regression was used to assess associations, which were tested by estimating odds ratios (ORs) with 95% confidence intervals (CIs). Results: Compared with the lowest quartile, the multivariable-adjusted ORs and 95% CIs for highest quartile were 0.32 (95% CI 0.20, 0.52; P-trend
The Author(s). Published by S. Karger AG, Basel
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