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Research Article
Kataoka H.
Introduction: The present study examined the possible estimation of plasma renin activity (PRA) by serum and urinary concentrations of chloride vs. sodium in acute and chronic heart failure (HF). Methods: Data from 29 patients with acute HF (48% men;80.3±12 years-old) and 26 patients with recovery of HF after decongestive therapy (50% men;81.2±12 years-old) were analyzed. Blood and urine samples were obtained immediately before decongestive therapy in acute HF patients. Clinical tests included peripheral blood tests, serum and spot urinary electrolytes, and plasma neurohormones. Sodium- or chloride-related indices included serum ([sNa+] or [sCl-]) and urinary ([uNa+] or [uCl-]) concentrations, their differences, and their ratio. Linear regression analysis was used for correlation coefficients. Results: PRA levels higher than the normal range were detected in only 5 (17%) of 29 patients with acute HF, but in as many as 11 (42%) of 26 patients with chronic HF. In the 29 patients with acute HF, all the chloride- and sodium-related indices except for [sNa+] were correlated with PRA: the [sCl-]/[uCl-] ratio were best correlated with PRA (R2=0.84, p
The Author(s). Published by S. Karger AG, Basel
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