∗Postgraduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul

†Professor of Pediatrics for Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre

‡Translational Research Group in Autism Spectrum Disorders

§Neuroglial Plasticity Laboratory, Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre

∥National Institute of Science and Technology on Neuroimmunomodulation, Rio de Janeiro

¶Postgraduate Program in Biological Sciences: Biochemistry, Department of Biochemistry

#Postgraduate Program in Cellular and Molecular Biology, Center of Biotechnology, Laboratory of Genomes and Plant Populations, Universidade Federal do Rio Grande do Sul

∗∗Department of Pediatrics, Child Neurology Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.

J.M. and I.D. contributed equally to the article.

Address correspondence and reprint requests to Josemar Marchezan, PhD, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600-21111, CEP: 90035-003 Porto Alegre, Rio Grande do Sul, Brazil; E-mail: [email protected]; Carmem Gottfried, PhD, Departamento de Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2600-21111, CEP: 90035-003 Porto Alegre, Rio Grande do Sul, Brazil; E-mail: [email protected]

Conflicts of Interest and Source of Funding: The authors declare that there is no conflict of interest. Due to its exploratory nature, treatment with resveratrol was not maintained after the period of the study. This work was supported by HCPA Research and Events Investment Fund (FIPE-HCPA #2017-0132); Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM #465489/2014-1), Rio de Janeiro, Brazil; National Council of Technological and Scientific Development (coauthors scholarship); Coordination for the Improvement of Higher Education Personnel (coauthors scholarship).

Author contributions: J.M., I.D., R.R., and C.G. contributed to the conceptualization, data curation, formal analysis, project administration, and visualization. R.R. and C.G. contributed to the funding acquisition, supervision, and resources. J.M. and I.D. contributed to the investigation and roles/writing—original draft. J.M., I.D., and G.C.F. contributed to the validation and methodology. C.G., R.R., and R.M. contributed to the writing—review and editing.

Data availability: The data sets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.

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