aDepartment of Pathophysiology and Transplantation, University of Milan and

bDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy

*Dr. Andrea Boscutti and Dr. Guido Cereda contributed equally to the writing of this article.

Received 28 February 2022 Accepted 8 March 2022

Correspondence to Paolo Brambilla, PhD, Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy, Tel: +39 0255035982; e-mail: [email protected]