Catalano M. · Ramello M. · Conca R. · Aprile G. · Petrioli R. · Roviello G.

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Article / Publication Details Abstract

Background: Chemotherapy induced peripheral neuropathy (CIPN) is one of the most frequently adverse events observed with taxanes use, whose disability often required modification or treatment discontinuation. The aim of this study was to assess the value of several variables as risk factors for CIPN development. Material and methods: Eligible patients with metastatic pancreatic cancer receiving chemotherapy with nab-paclitaxel and gemcitabine were assessed in a multicenter study. Peripheral neuropathy was categorized used the National Cancer Institute Common Toxicity Criteria scale, version 4.02 and a physical/neurological examination. Univariate and multivariate regression analysis were used to identify blood-based and clinical factors associated with CIPN. Results: Data were available from 153 patients from five Italian centers. Key risk factors of CIPN in univariate regression models included age, number of chemotherapy cycles, statin assumption and concomitant comorbidities. However, in the multivariate analysis, only for age (OR 1.0 p

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