Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water

Lucas Michelão Martins, Vitor Fernandes Moreno, Ilana Sganzerla Rosário, Carlos Frederico de Oliveira Graeff, Luiz Carlos Silva Filho

Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diaryl-quinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diaryl-quinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions.

DOI: http://dx.doi.org/10.17807/orbital.v14i1.1689

Acid Catalyst; Green Synthesis; Nitrogen Heterocycles; Quinoline.

This work is licensed under a Creative Commons Attribution 3.0 License.

Institute of Chemistry - Universidade Federal de Mato Grosso do Sul. Copyright © 2021
Phone: +55 67 3345 3676. Av. Senador Filinto Müller, 1555 – Vila Ipiranga, CEP: 79074-460 – Campo Grande – MS, Brazil