1. Zheng, Y, Ley, SH, Hu, F. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98.
Google Scholar | Crossref | Medline2. Wild, S, Roglic, G, Green, A, Sicree, R, King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–1053.
Google Scholar | Crossref | Medline | ISI3. Godenberg, R, Punthakee, Z. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes. 2013;37(suppl 1):S8–S11.
Google Scholar | Crossref | Medline4. Einarson, TR, Acs, A, Ludwig, C, Panton, UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1):83.
Google Scholar | Crossref | Medline5. Bertram, MY, Jaswal, AV, Van Wyk, VP, Levitt, NS, Hofman, KJ. The non-fatal disease burden caused by type 2 diabetes in South Africa, 2009. Glob.l Health Action. 2013;6:19244.
Google Scholar | Crossref | Medline6. Jamshidi-Kia, F, Lorigooini, Z, Amini-Khoei, H. Medicinal plants: past history and future perspective. J Herbmed Pharmacol. 2018;7(1):1-7.
Google Scholar | Crossref7. Thring, TSA, Weitz, FM. Medicinal plant use in the bredasdorp/elim region of the southern overberg in the western cape province of South Africa. J Ethnopharmacol. 2006;103(2):261–275.
Google Scholar | Crossref | Medline8. Erasto, P, Adebola, PO, Grierson, DS, Afolayan, AJ. An ethnobotanical study of plants used for the treatment of diabetes in eastern cape province, South Africa. Afr J Biotechnol. 2005;4(12):1458–1460.
Google Scholar9. Mongalo, NI, Mafoko, BJ. Cassia abbreviata Oliv. a review of its ethnomedicinal uses toxicology, phytochemistry, possible propagation techniques and Pharmacology. Afr J Pharm Pharmacol. 2013;7(45):2901–2906.
Google Scholar | Crossref10. Morejane, W, Legwaila, GM, Mogotsi, KK, Tshwenyane, SO. Monepenepe (Cassia abbriviata): a medicinal plant in Botswana. Int J Botany. 2005;1(2):108–110.
Google Scholar | Crossref11. Muthaura, CN, Rukunga, GM, Chhabra, SC, Mungai, GM, Njagi, ENM. Traditional antimalarial phytotherapy remedies used by the Kwale community of the Kenyan Coaast. J Ethnopharmacol. 2007;114(3):377–386.
Google Scholar | Crossref | Medline12. Maroyi, A . Traditional use of medicinal plants in south-central Zimbabwe: review and perspectives. J Ethnobiol Ethnomedicine. 2013;9(31):1–18.
Google Scholar | Medline13. Augustino, S, Hall, JB, Makonda, FBS, Ishengoma, RC. Medicinal resources of the miombo woodlands of Urumva, Tanzania: plants and its uses. J Med Plants Res. 2011;5(27):6352–6372.
Google Scholar14. Seabi, IM, Motaung, S C K M, Ssemakalu, CC, Mokgotho, MP, Mogale, AM, Shai, LJ. Effects of Cassia abbreviata Oliv. and Helinus integrifolius (Lam.) Kuntze on glucose uptake, glut-4 expression and translocation in muscle (C2C12 mouse myoblasts) cells. int. J Pharmacogn Phytochem. 2016;8(6):1003–1009.
Google Scholar15. Patel, DK, Prassad, SK, Kumar, R, Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012;2(4):320–330.
Google Scholar | Crossref | Medline16. Syiem, D, Warjri, P. Hypoglycemic and antihyperglycemic effects of aqueous extract of Ixeris Gracilis on normal and alloxans-induced diabetic mice. Diabetol Croat. 2011;40(3):89–94.
Google Scholar17. Tremblay, F, Dubois, MJ, Marette, A. Regulation of GLUT-4 traffic and function by insulin and contraction in skeletal muscle. Front Biosci. 2003;8:1072–1084.
Google Scholar | Crossref | Medline18. Bryant, GN, Govers, R, James, DE. Regulated transport of the glucose transporter GLUT4. Mol Biol. 2002;3(4):267–277.
Google Scholar19. Jewell, JL, Thurmond, DC. Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4. Am J Physiol Regul Integr Comp Physiol. 2010, 298(3):517–531.
Google Scholar | Crossref20. Kadan, S, Sasson, Y, Abu-Reziq, R. et al. Teucrium polium extracts stimulate GLUT4 translocation to the plasma membrane in L6 muscle cells. Adv Med Plant Res. 2018;6(1):1–8.
Google Scholar | Crossref21. Huang, X, Liu, G, Guo, J, Su, Z. The PI3K/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci. 2018;14(11):1483–1496.
Google Scholar | Crossref | Medline22. Lee, MS, Hwang, JT, Kim, SH. et al. Gin senoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. J Ethnopharmacol. 2010;127(3):771–776.
Google Scholar | Crossref | Medline23. Sarbassov, DD, Siraj, MA, Sabatini, DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol. 2005;17(6):596–603.
Google Scholar | Crossref | Medline | ISI24. Gosmanov, AR, Umpierrez, GE, Karabell, AH, Cuervo, R, Thomason, DB. Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes. Am J Physiol Endocrinol Metab. 2004;287(1):E8–E15.
Google Scholar | Crossref | Medline25. Huang, S, Czech, MP. The GLUT-4 transporter. Cell Metab. 2007;5(4):237–252.
Google Scholar | Crossref | Medline26. Mosmann, HMT . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods. 1983;65(1-2):55–63.
Google Scholar | Crossref | Medline | ISI27. Van de Venter, M, Roux, S, Bungu, LC. et al. Antidiabetic screening and scoring of 11 plants traditionally used in South Africa. J Ethnopharmacol. 2008;119(1):81–86.
Google Scholar | Crossref | Medline28. Divya, SP, Son, YO, Roy, RV. et al. Arsenic Induces insulin resistance in mouse adipocytes and myotubes via oxidative stress-regulated mitochondrial Sirt3-FOXO3a signaling pathway. Toxicol sci. 2015;146(2):290–300.
Google Scholar | Crossref | Medline29. Steenkamp, V, Mokoele, TL, van Rensburg, CEJ. Toxicity testing of two medicinal plants, Bridelia micrantha and Antidesma venosum. Open Toxicol J. 2009;3:35–38.
Google Scholar | Crossref30. Cholendra, A, Vijayaraghavan, R, Babu, Y. et al. Acute toxicity studies of cassia tora leaf powder. Int J Pharmacol Res. 2014;4(4):176–181.
Google Scholar31. Akanmu, MA, Iwalewa, EO, Elujoba, AA, Adelusola, KA. Toxicity potentials of cassia Fistula fruits as laxative with reference to senna. Afr J Biomed Res. 2004;7(1):23–26.
Google Scholar32. Jothy, SL, Zakaria, Z, Chen, Y, Lau, YL, Latha, LY, Sasidharan, S. Acute oral toxicity of methanolic seed extract of cassia fistula in mice. Mol. 2011;16(6):5268–5282.
Google Scholar | Crossref | Medline33. Fonseca, AG, Dantas, LLSFR, Fernandes, JM. et al. In Vivo and In Vitro toxicity evaluation of hydroethanolic extract of Kalanchoe brasiliensis (Crassulaceae) leaves. J Toxicol. 2018;18:1–8.
Google Scholar | Crossref34. Silawat, N, Jarald, EE, Jain, N, Yadav, A, Deshmukh, P. The mechanism of hypoglycemic and antidiabetic action of hydroalcholic extract of cassia fistula Linn. in rats. Pharm Res. 2009;1:82–92.
Google Scholar35. Bati, K, Kwape, TE, Chaturvedi, P. Anti-diabetic effects of an ethanol extract of cassia abbreviata stem bark on diabetic rats and possible mechanism of its action. J Pharmacopunct. 2017;20(1):045–051.
Google Scholar | Crossref | Medline36. Shalaby, MA, Saifan, HY. Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats. J intercult Ethnopharmacol. 2014;3(4):144–149.
Google Scholar | Crossref | Medline37. Al-Khalili, L, Chibalin, AV, Kannisto, K. et al. Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content. Cell Mol Life Sci. 2003;60(5):991–998.
Google Scholar | Crossref | Medline38. Govers, R . Molecular mechanisms of GLUT4 regulation in adipocytes. Diabetes Metab. 2014;40(6):400–410.
Google Scholar | Crossref | Medline39. Huang, M, Deng, S, Han, Q. et al. Hypoglycemic activity and the potential mechanism of the flavonoid Rich extract from Sophora tonkinensis Gagnep. in KK-Ay Mice. Front Pharmacol. 2016;7:288.
Google Scholar | Crossref | Medline40. Girón, MD, Sevillano, N, Salto, R. et al. Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin. Clin Nutr. 2009;28(5):565–574.
Google Scholar | Crossref | Medline41. Shen, Y, Honma, N, Kobayashi, K. et al. Cinnamon extract enhances glucose uptake in 3 T3–L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signalling. PLoS One. 2014;9(2):e87894.
Google Scholar | Crossref | Medline42. Dawson, PA, Mychaleckyj, JC, Fossey, SC, Mihic, SJ, Craddock, AL, Bowden, DW. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001;74(1-2):186–199.
Google Scholar | Crossref | Medline43. Evans, PL, McMillin, SL, Weyrauch, LA, Witczak, CA. Regulation of skeletal muscle glucose transport and glucose metabolism by exercise training. Nutrients. 2019;2432(11):1–24.
Google Scholar44. Morris, AJ, Martin, SS, Haruta, T. et al. Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation. Proc Natl Acad Sci USA. 1996;93(16):8401–8406.
Google Scholar | Crossref | Medline45. Hashiramoto, M, James, DE. Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes. Mol Cell Biol. 2000;20(1):416–427.
Google Scholar | Crossref | Medline46. Zhao, P, Tian, D, Song, G. et al. Neferine promotes GLUT4 expression and fusion in plasma membrane to induce glucose uptake in L6 cells. Front Pharmacol. 2019;10(999):1–16.
Google Scholar | Medline47. Cai, Y, Wang, Y, Zhi, F, Xing, Q, Chen, Y. The effect of sanggua drink extract on insulin resistance through the pi3k/Akt signaling pathway. Evid Based Complementary Altern Med. 2018;2018:1–9.
Google Scholar48. Yoshitomi, H, Tsuru, R, Li, L. et al. Cyclocarya paliurus extract activates insulin signalling via Sirtuin1 in C2C12 myotubes and decreases blood glucose level in mice with impaired insulin secretion. PLoS One. 2017;12(8):0183988.
Google Scholar | Crossref49. Prabhakar, PK, Doble, M. Effect of natural products on commercial oral antidiabetic drugs in enhancing 2-Deoxyglucose uptake by 3T3-L1 adipocytes. Ther Adv Endocrinol Metab. 2011;2(3):103–114.
Google Scholar | SAGE Journals50. Gray, AM, Flatt, PR. Antihyperglycemic actions of eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice. J Nutr. 1998;128(12):2319–2323.
Google Scholar | Crossref | Medline51. Tian, C, Chang, H, La, X, Li, J. Wushenziye formula improves skeletal muscle insulin resistance in type 2 diabetes mellitus via PTP1B-IRS1-Akt-GLUT4 signaling pathway. Evid Based Complementary Altern Med. 2017;2017:1–8.
Google Scholar | Crossref52. Li, W, Liang, X, Zeng, Z. et al. Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signalling in C2C12 myotubes. Biomed Pharmacother. 2016;83:194–200.
Google Scholar | Crossref | Medline53. Konishi, H, Shinomura, T, Kuroda, S, Ono, Y, Kikkawa, U. Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Biochem Bioph Res Co. 1994;205(1):817–825.
Google Scholar | Crossref | Medline54. Sokolowska, E, Blachnio-Zabielska, A. The role of ceramides in insulin resistance. Front Endocrinol. 2019;10:577.
Google Scholar