This meta-analysis was conducted to evaluate the effects of garlic extract on total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-c) and high-density lipoprotein-cholesterol (HDL-c), among the patients with coronary artery disease (CAD). Literature searches were conducted in EMBASE, Scopus, PubMed, Web of Science and Cochrane Library until Sep18th, 2020. Inter-study heterogeneity was examined using Cochrane's Q and I2 tests. The random-effect models were utilised to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Six articles were enrolled in the current meta-analysis. Garlic consumption significantly reduced TC levels (WMD −16.32 mg/dL; 95% CI −31.22, −1.43; P = .032). We found no significant effects on TG (WMD −10.93 mg/dL; 95% CI −26.19, 4.32; P = .160), HDL-c (WMD 4.55 mg/dL; 95% CI −1.13, 10.23; P = .116) and LDL-c concentrations (WMD −3.65 mg/dL; 95% CI −13.21, 5.92; P = .455). Significant heterogeneity was observed for HDL-c (I2 = 76.8%). However, the findings of sensitivity analysis revealed that upon exclusion of the potential heterogeneity source, the pooled WMD on HDL-c levels were stable. Garlic supplementation may result in a decrease in TC, but will not affect TG, HDL-c and LDL-c levels among CAD patients.