This cover image represents the bioconvergence between microfluidics, 3D bioprinting, lab-on-chip and microgravity technologies to develop a new approach towards the development and understanding of complex biological microenvironments including brain cancer which is described in this study. The emergence of space mechanobiology has demonstrated potential to unveiling biological mechanisms and disease function. This is reported by Joshua Chou and co-workers in article number 2100106.