Figure S1. The process of MIPs synthesis and selective binding for S-DABN.

Figure S2. Molecular optimized configuration and corresponding Mulliken charge distribution.

Figure S3. The influence of mixing temperatures on chemical shifts with [S-DABN]/[MAA] = 1:4 in 3 mL acetonitrile-d3.

Figure S4. FT-IR spectra of MIP (P2) (a) before and (b) after removal of S-DABN, (c) NIP (P0).

Figure S5. TG and DTG curves of (a) MIP (P2) and (b) NIP (P0) at a heating rate of 10°C min−1 from room temperature to 800°C in N2 atmosphere.

Figure S6. (a) The relationship between ln (Qe-Q) and t; (b) t/Q and t for the first-and second-order adsorption models, respectively. ([S-DABN]0 = 35 mg L−1 in 20 mL acetonitrile, the mass of MIP (P2) was 25.0 mg at 25°C)

Figure S7. Fitting curve of lnKd versus 1/T for S-DABN adsorption by MIP (P2).

Table S1. Effect of MIPs adsorbent types on the selective extraction by MIP-MTSPE.

Figure S8. HPLC chromatograms of DABN racemic samples after extraction by MIP-MTSPE equipped with different MIP (P2). Chromatographic conditions: OD column (4.6 × 250 mm), mobile phase: N-hexane: Isopropanol (95: 5, v/v), flow rate: 0.50 mL min−1; sample loading, 5 μL DABN racemic samples after MIP-MTSPE treatment, and the initial concentration of samples before MIP-MTSPE treatment were (a) 0.08 mg mL−1, (b) 0.28 mg mL−1 and (c) 0.80 mg mL−1 respectively.

Table S2. Recoveries of S-DABN samples after selective extraction by MIP-MTSPEa.