1. Manohar, M, Verma, AK, Venkateshaiah, SU, et al. (2017) Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther 8(1): 10–25.
Google Scholar | Crossref | Medline2. Choi, JW, Lee, SK, Kim, MJ, et al. (2019) Piperine ameliorates the severity of fibrosis via inhibition of TGF-β/SMAD signaling in a mouse model of chronic pancreatitis. Mol Med Rep 20(4): 3709–3718.
Google Scholar | Medline3. Wellendorph, P, Johansen, LD, Brauner-Osborne, H (2009) Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol 76(3): 453–46532.
Google Scholar | Crossref | Medline4. Muddana, V, Lamb, J, Greer, JB, et al. (2008) Association between calcium sensing receptor gene polymorphisms and chronic 12 Dose-Response: an International Journal pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. World J Gastroenterol 14(28): 4486–4491.
Google Scholar | Crossref | Medline5. Gemici, C, Yaprak, G, Ozdemir, S, et al. (2018) Volumetric decrease of pancreas after abdominal irradiation, it is time to consider pancreas as an organ at risk for radiotherapy planning. Radiat Oncol 13(1): 238.
Google Scholar | Crossref | Medline6. Zhang, X, Jin, T, Shi, N, et al. (2019) Mechanisms of pancreatic injury induced by basic amino acids differ between L-Arginine, L-Ornithine, and L-Histidine. Front Physiol 9: 1922. DOI: 10.3389/fphys.2018.01922.
Google Scholar | Crossref | Medline7. Jung, KH, Song, SU, Yi, T, et al. (2011) Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats. Gastroenterology 140(3): 998–1008.
Google Scholar | Crossref | Medline | ISI8. Gong, J, Meng, HB, Hua, J, et al. (2014) The sdf-1/cxcr4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis. Mol Med Rep 9(5): 1575–1582.
Google Scholar | Crossref | Medline9. Kawakubo, K, Ohnishi, S, Kuwatani, M, et al. (2018) Mesenchymal stem cell therapy for acute and chronic pancreatitis. J Gastroenterol 53(1): 1–5.
Google Scholar | Crossref | Medline10. Moustafa, EM, Moawed, FSM, Abdel-Hamid, GR (2020) Icariin promote stem cells regeneration and repair acinar cells in L-arginine/radiation -inducing chronic pancreatitis in rats. Dose Response 18(4): 1559325820970810.
Google Scholar | SAGE Journals | ISI11. Scuteri, A, Monfrini, M (2018) Mesenchymal stem cells as new therapeutic approach for diabetes and pancreatic disorders. Int J Mol Sci 19(9): 2783.
Google Scholar | Crossref12. Alhadlaq, A, Mao, JJ (2004) Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 13: 436–448.
Google Scholar | Crossref | Medline | ISI13. Rochefort, GY, Vaudin, P, Bonnet, N, et al. (2005) Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies? Respir Res 6: 125.
Google Scholar | Crossref | Medline | ISI14. Charan, J, Kantharia, ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4: 303–306. DOI: 10.4103/0976-500X.119726.
Google Scholar | Crossref | Medline15. Zhang, WX, Zhao, JH, Ping, FM, Liu, ZJ, Gu, JX, Lu, XQ (2016 Mar) Effect of dimethyl fumarate on rats with chronic pancreatitis. Asian Pac J Trop Med 9(3): 261–264.
Google Scholar | Crossref | Medline16. Park, SI, Lim, JY, Jeong, CH, et al. (2012) Human umbilical cord blood-derived mesenchymal stem cell therapy promotes functional recovery of contused rat spinal cord through enhancement of endogenous cell proliferation and oligogenesis. J Biomed Biotechnol 2012: 362473.
Google Scholar | Crossref | Medline17. Tsuzuki, W, Ue, A, Nagao, A, et al. (2004) Inhibitory effect of lysophosphatidylcholine on pancreatic lipase-mediated hydrolysis in lipid emulsion. Biochim Biophys Acta 1684(1–3): 1–7.
Google Scholar | Crossref | Medline18. Friedewald, WT, Levy, RI, Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499–502.
Google Scholar | Crossref | Medline | ISI19. Rombouts, WJ, Ploemacher, RE (2003) Primary murine MSC shows highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 17: 160–170.
Google Scholar | Crossref | Medline | ISI20. Peister, A, Mellad, JA, Larson, BL, Hall, BM, Gibson, LF, Prockop, DJ (2004) Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation and differentiation potential. Blood 103: 1662–1668.
Google Scholar | Crossref | Medline | ISI21. Phinney, DG, Kopen, G, Isaacson, RL, Prockop, DJ (1999) Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth and differentiation. J Cell Biochem 72: 570–585.
Google Scholar | Crossref | Medline | ISI22. Bancroft, JD, Stevans, A, Dawswon, MP (1996) Theory and Practice of Histological Techniques. 4th edition. Edinbergh, London and New York: Churchill Livingstone, 273–292.
Google Scholar23. Lew, D, Afghani, E, Pandol, S (2017) Chronic pancreatitis: current status and challenges for prevention and treatment. Dig Dis Sci 62(7): 1702–1712.
Google Scholar | Crossref | Medline24. Zachar, L, Bačenková, D, Rosocha, J (2016) Activation, homing, and role of the mesenchymal stem cells in the inflammatory environment. J Inflamm Res 9: 231–240.
Google Scholar | Crossref | Medline25. Abu Dayyeh, BK, Conwell, D, Buttar, NS, et al. (2015) Pancreatic juice prostaglandin e2 concentrations are elevated in chronic pancreatitis and improve detection of early disease. Clin Transl Gastroenterol 6(1): e72.
Google Scholar | Crossref | Medline26. Kishino, Y, Kawamura, S (1984) Pancreatic damage induced by injecting a large dose of arginine. Virchows Arch B Cell Pathol Incl Mol Pathol 47: 147–155.
Google Scholar | Crossref | Medline27. Kubisch, CH, Sans, MD, Arumugam, T, et al. (2006) Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 291(2): G238–G245.
Google Scholar | Crossref | Medline28. Ahmed, SM, Morsi, M, Ghoneim, NI, et al. (2018) Mesenchymal stromal cell therapy for pancreatitis: a systematic review. Oxid Med Cell Longev 2018: 3250864.
Google Scholar | Crossref | Medline29. Zhang, Y, Kong, WN, Chai, XQ (2018) Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer’s disease mice. Neural Regen Res 13(4): 731–736.
Google Scholar | Crossref | Medline30. Zhou, CH, Li, ML, Qin, AL, et al. (2013) “Reduction of fibrosis in dibutyltin dichloride–induced chronic pancreatitis using rat umbilical mesenchymal stem cells from Wharton’s jelly. Pancreas 42(8): 1291–1302.
Google Scholar | Crossref | Medline31. Jin, G, Hong, W, Guo, Y, et al. (2020) Molecular mechanism of pancreatic stellate cells activation in chronic pancreatitis and pancreatic cancer. J Cancer 11(6): 1505–1515.
Google Scholar | Crossref | Medline32. Schwer, CI, Stoll, P, Goebel, U, et al. (2012) Effects of hydrogen sulfide on rat pancreatic stellate cells. Pancreas 41: 74–83.
Google Scholar | Crossref | Medline33. Krysko, DV, Denecker, G, Festjens, N, et al. (2006) Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells. Cell Death Differ 13(12): 2011–2022.
Google Scholar | Crossref | Medline | ISI34. Choi, JW, Lee, SK, Kim, MJ, et al. (2019) Piperine ameliorates the severity of fibrosis via inhibition of TGF β/SMAD signaling in a mouse model of chronic pancreatitis. Mol Med Rep 20(4): 3709–3718.
Google Scholar | Medline35. Hamza, AA, Fikry, EM, Abdallah, W, et al. (2018) Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats. Sci Rep 8: 9827.
Google Scholar | Crossref | Medline36. González, AM, Garcia, T, Samper, E, et al. (2011) Assessment of the protective effects of oral tocotrienols in arginine chronic-like pancreatitis. Am J Physiol Gastrointest Liver Physiol 301(5): G846–G855.
Google Scholar | Crossref | Medline37. Scuteri, A, Monfrini, M (2018) Mesenchymal stem cells as new therapeutic approach for diabetes and pancreatic disorders. Int J Mol Sci 19(9): 2783.
Google Scholar | Crossref38. Nagasaki, H, Katsumata, T, Oishi, H, et al. Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb. PLoS One. 2014;9(11): e113022. DOI: 10.1371/journal.pone.0113022.
Google Scholar | Crossref | Medline39. Xie, H, Wang, Y, Zhang, H, et al. (2013) Role of injured pancreatic extract promotes bone marrow-derived mesenchymal stem cells efficiently differentiate into insulin-producing cells. PLoS One 8(9): e76056.
Google Scholar | Crossref | Medline