Title:Characteristics and Determinants of Pulse Pressure-age Relationship in Healthy and Non-treated Hypertensive Subjects of Argentinean Population

VOLUME: 17 ISSUE: 2

Author(s):Alejandro Díaz*, Ariel F. Pascaner, Sandra Wray and Edmundo C. Fischer

Affiliation:Instituto de Investigación en Ciencias de la Salud, UNICEN-CONICET, Tandil, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) - CONICET-UF, Buenos Aires, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) - CONICET-UF, Buenos Aires, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) - CONICET-UF, Buenos Aires

Keywords:Pulse pressure, pulse wave velocity, arterial, stiffness, ageing, cfPWV, hypertension.

Abstract:

Background: The relationship between the increases in pulse pressure (PP) and arterial stiffness determined by aging or systemic hypertension has been widely reported. These findings are supported by large-cohort analyzes conducted in well-known populations, such as Framingham Study. However, there is evidence that an age-PP curvilinear relationship may exist in hypertensive subjects. This study aimed to evaluate the age-related change in pulse pressure and arterial stiffness in a population-based study.

Methods: Carotid-femoral Pulse Wave Velocity (cfPWV) were obtained in 2075 subjects.

Results: Age-related changes of PP showed a curvilinear relationship (R=0.39, p Conclusion: In conclusion, age-related changes in PP showed a curvilinear relationship and no parallelism with the age-cfPWV relationship for both normotensive and hypertensive subjects. The determinants of PP impact it differently depending on age and the pathological condition of the subject.