1. Kaufman, G . Asthma: pathophysiology, diagnosis and management. Nurs Stand 2011; 26: 48–56, quiz 58. 2011/11/12. DOI: 10.7748/ns2011.10.26.5.48.c8744.
Google Scholar | Crossref | Medline2. Kavanagh, J, Jackson, DJ, Kent, BD. Over- and under-diagnosis in asthma. Breathe 2019; 15: e20–e27. DOI: 10.1183/20734735.0362-2018.
Google Scholar | Crossref | Medline3. Nolte, H, Nepper-Christensen, S, Backer, V. Unawareness and undertreatment of asthma and allergic rhinitis in a general population. Respir Medicine 2006; 100: 354–362.
Google Scholar | Crossref | Medline4. Ali, M, Krusemark, E, Wi, CI, et al. Delay in asthma diagnosis and risk of common respiratory infection in young children. J Allergy Clin Immunol 2016; 137: AB32. DOI: 10.1016/j.jaci.2015.12.106.
Google Scholar | Crossref5. Accordini, S, Cappa, V, Braggion, M, et al. The impact of diagnosed and undiagnosed current asthma in the general adult population. Int Arch Allergy Immunol 2011; 155: 403–411. DOI: 10.1159/000320780. 2011/02/25.
Google Scholar | Crossref | Medline | ISI6. Backer, V, Harmsen, L, Lund, T, et al. A 3-year longitudinal study of asthma quality of life in undiagnosed and diagnosed asthma patients. International Journal Tuberculosis Lung Disease : The Official Journal Int Union Against Tuberculosis Lung Dis 2007; 11: 463–469. DOI: 2007/03/31.
Google Scholar | Medline7. Aaron, SD, Vandemheen, KL, FitzGerald, JM, et al. Reevaluation of diagnosis in adults with physician-diagnosed asthma. JAMA 2017; 317: 269–279. DOI: 10.1001/jama.2016.19627.
Google Scholar | Crossref | Medline8. Shaw, D, Green, R, Berry, M, et al. A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma. Prim Care Respir J 2012; 21: 283–287. DOI: 10.4104/pcrj.2012.00057.
Google Scholar | Crossref | Medline9. Kroegel, C . Global initiative for asthma (GINA) guidelines: 15 years of application. Expert Rev Clin Immunol 2009; 5: 239–249. DOI: 10.1586/eci.09.1. 2010/05/19.
Google Scholar | Crossref | Medline | ISI10. Schneider, A, Gindner, L, Tilemann, L, et al. Diagnostic accuracy of spirometry in primary care. BMC Pulm Med 2009; 9: 31, journal article 2009/07/14. DOI: 10.1186/1471-2466-9-31.
Google Scholar | Crossref | Medline11. Fortuna, AM, Feixas, T, González, M, et al. Diagnostic utility of inflammatory biomarkers in asthma: Exhaled nitric oxide and induced sputum eosinophil count. Respir Med 2007; 101: 2416–2421. DOI: 10.1016/j.rmed.2007.05.019.
Google Scholar | Crossref | Medline12. Ozarek-Hanc, A, Olczak, S, Majak, P, et al. Usefulness of bronchial reversibility test in asthma diagnosis in children. Alergia Astma Immunologia 2012; 17: 83–88.
Google Scholar13. Sivan, Y, Gadish, T, Fireman, E, et al. The use of exhaled nitric oxide in the diagnosis of asthma in school children. J Pediatr 2009; 155: 211–216. DOI: 10.1016/j.jpeds.2009.02.034. 2009/04/28.
Google Scholar | Crossref | Medline | ISI14. Motamedi-Fakhr, S, Wilson, RC, Iles, R. Tidal breathing patterns derived from structured light plethysmography in COPD patients compared with healthy subjects. Med Devices: Evid Res 2017; 10: 1–9. DOI: 10.2147/MDER.S119868. 2017/01/18
Google Scholar | Crossref | Medline15. Quanjer, PH, Stanojevic, S, Cole, TJ, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J 2012; 40: 1324–1343. DOI: 10.1183/09031936.00080312.
Google Scholar | Crossref | Medline | ISI16. van den Berge, M, ten Hacken, NHT, Cohen, J, et al. Small airway disease in asthma and COPD. Chest 2011; 139: 412–423. DOI: 10.1378/chest.10-1210.
Google Scholar | Crossref | Medline | ISI17. Kuyper, LM, Paré, PD, Hogg, JC, et al. Characterization of airway plugging in fatal asthma. Am J Med 2003; 115: 6–11. DOI: 10.1016/s0002-9343(03)00241-9. 2003/07/18.
Google Scholar | Crossref | Medline | ISI18. Singer, F, Abbas, C, Yammine, S, et al. Small airways function in children with mild asthma and normal FEV1. Eur Respir J 2013; 42: 1485.
Google Scholar19. Balzar, S, Wenzel, SE, Chu, HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002; 20: 254–259. DOI: 2002/09/0610.1183/09031936.02.00261102.
Google Scholar | Crossref | Medline | ISI20. van der Molen, T, Postma, DS, Martin, RJ, et al. Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands. BMC Pulm Med 2016; 16: 80. DOI: 10.1186/s12890-016-0234-0.
Google Scholar | Crossref | Medline21. Matsuba, K, Thurlbeck, WM. The number and dimensions of small airways in nonemphysematous lungs. Am Review Respiratory Disease 1971; 104: 516–524. DOI: 10.1164/arrd.1971.104.4.516.
Google Scholar | Crossref | Medline22. Usmani, OS, Singh, D, Spinola, M, et al. The prevalence of small airways disease in adult asthma: a systematic literature review. Respir Med 2016; 116: 19–27. DOI: 10.1016/j.rmed.2016.05.006. 2016/06/15.
Google Scholar | Crossref | Medline23. Macklem, PT, Mead, J. Resistance of central and peripheral airways measured by a retrograde catheter. J Appl Physiol 1967; 22: 395–401. DOI: 10.1152/jappl.1967.22.3.395.
Google Scholar | Crossref | Medline | ISI24. Mead, J . The lung's quiet zone. New Engl J Med 1970; 282: 1318–1319. DOI: 10.1056/NEJM197006042822311.
Google Scholar | Crossref | Medline25. Cottini, M., Lombardi, C., Micheletto, C. Small airway dysfunction and bronchial asthma control: the state of the art. Asthma Res Pract 2015; 1: 13. DOI: 10.1186/s40733-015-0013-3.
Google Scholar | Crossref | Medline26. Johnson, JR, Hamid, Q. Appraising the small airways in asthma. Curr Opin Pulm Med 2012; 18: 23–28. DOI: 10.1097/MCP.0b013e32834dd8c2. 2011/11/25.
Google Scholar | Crossref | Medline27. Dolhnikoff, M, da Silva, LFF, de Araujo, BB, et al. The outer wall of small airways is a major site of remodeling in fatal asthma. J Allergy Clin Immunol 2009; 123: 1090–1097. DOI: 1097 e1091. 2009/04/1410.1016/j.jaci.2009.02.032.
Google Scholar | Crossref | Medline28. Kraft, M., Djukanovic, R., Wilson, S, et al. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 1996; 154: 1505–1510. DOI: 10.1164/ajrccm.154.5.8912772. 1996/11/01.
Google Scholar | Crossref | Medline | ISI29. Saetta, M, Di Stefano, A, Rosina, C, et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991; 143: 138–143. DOI: 10.1164/ajrccm/143.1.138. 1991/01/01.
Google Scholar | Crossref | Medline | ISI30. Shiang, C., Mauad, T., Senhorini, A, et al. Pulmonary periarterial inflammation in fatal asthma. Clin Exp Allergy 2009; 39: 1499–1507. DOI: 10.1111/j.1365-2222.2009.03281.x. 2009/06/03.
Google Scholar | Crossref | Medline31. Gelfand, EW, Kraft, M. The importance and features of the distal airways in children and adults. J Allergy Clin Immunol 2009; 124: S84–S87. DOI: 10.1016/j.jaci.2009.07.062.
Google Scholar | Crossref | Medline32. Postma, DS, Brightling, C, Baldi, S, et al. Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study. Lancet Respir Med 2019; 7: 402–416, Article. DOI: 10.1016/s2213-2600(19)30049-9.
Google Scholar | Crossref | Medline33. Duffey, H, Anderson, WC. It's time to start phenotyping our patients with asthma. Immunol Allergy Clin North America 2019; 39: 561–572. DOI: 10.1016/j.iac.2019.07.009. 2019/09/30.
Google Scholar | Crossref | Medline34. Bostantzoglou, C, Delimpoura, V, Samitas, K, et al. Clinical asthma phenotypes in the real world: opportunities and challenges. Breathe 2015; 11: 186–193. DOI: 10.1183/20734735.008115. 2015/12/04.
Google Scholar | Crossref | Medline35. Keet, CA, Matsui, EC, McCormack, MC, et al. Urban residence, neighborhood poverty, race/ethnicity, and asthma morbidity among children on Medicaid. J Allergy Clin Immunol 2017; 140: 822–827. DOI: 10.1016/j.jaci.2017.01.036. 2017/03/12.
Google Scholar | Crossref | Medline36. Haldar, P, Pavord, ID, Shaw, DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178: 218–224. DOI: 10.1164/rccm.200711-1754OC. 2008/05/16.
Google Scholar | Crossref | Medline | ISI37. Pavord, I . Asthma phenotypes. Semin Respir Crit Care Med 2012; 33: 645–652. DOI: 10.1055/s-0032-1326962. 2012/10/11.
Google Scholar | Crossref | Medline38. Kjellberg, S, Houltz, BK, Zetterström, O, et al. Clinical characteristics of adult asthma associated with small airway dysfunction. Respir Med 2016; 117: 92–102. DOI: 10.1016/j.rmed.2016.05.028.
Google Scholar | Crossref | Medline39. Telenga, ED, van den Berge, M, ten Hacken, NHT, et al. Small airways in asthma: their independent contribution to the severity of hyperresponsiveness: Table 1-. Eur Respir J 2013; 41: 752–754. DOI: 10.1183/09031936.00170912.
Google Scholar | Crossref | Medline40. Leach, CL, Davidson, PJ, Boudreau, RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J 1998; 12: 1346–1353. DOI: 10.1183/09031936.98.12061346. 1999/01/07.
Google Scholar | Crossref | Medline | ISI41. Busse, WW, Brazinsky, S, Jacobson, K, et al. Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant☆☆☆★. J Allergy Clin Immunol 1999; 104: 1215–1222. DOI: 10.1016/s0091-6749(99)70016-3. 1999/12/10.
Google Scholar | Crossref | Medline | ISI42. Usmani, OS, Biddiscombe, MF, Barnes, PJ. Regional lung deposition and bronchodilator response as a function of β2-Agonist particle size. Am J Respir Crit Care Med 2005; 172: 1497–1504. DOI: 10.1164/rccm.200410-1414OC.
Google Scholar | Crossref | Medline | ISI43. Leach, CL, Bethke, TD, Boudreau, RJ, et al. Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteers. J Aerosol Med 2006; 19: 117–126. DOI: 10.1089/jam.2006.19.117. 2006/06/27.
Google Scholar | Crossref | Medline44. Newman, S, Salmon, A, Nave, R, et al. High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 2006; 100: 375–384. DOI: 10.1016/j.rmed.2005.09.027.
Google Scholar | Crossref | Medline |