The Janus kinase- signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is utilized by many pro-inflammatory molecules to mediate downstream effects and activate gene transcription. Activation of the JAK-STAT pathway contributes to a number of inflammatory dermatoses, and clinical trials and smaller studies have demonstrated the efficacy of JAK inhibitors in the treatment of a variety of dermatologic conditions. Herein we review the use of JAK inhibitors for the treatment of a wide range of dermatologic diseases in a two-part review series.