Kashyap S Meel R Singh L Singh M.

Uveal melanoma.

Semin Diagn Pathol. 33: 141-147Jager MJ Shields CL Cebulla CM Abdel-Rahman MH Grossniklaus HE Stern MH Carvajal RD Belfort RN Jia R Shields JA Damato BE.

Uveal melanoma.

Nat Rev Dis Primers. 6: 24Fogg VC Lanning NJ Mackeigan JP.

Mitochondria in cancer: at the crossroads of life and death.

Chin J Cancer. 30: 526-539Lightowlers RN Chinnery PF Turnbull DM Howell N.

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease.

Trends Genet. 13: 450-455

Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.

Cold Spring Harb Perspect Biol. 5a021220Alexeyev M Shokolenko I Wilson G LeDoux S.

The maintenance of mitochondrial DNA integrity – critical analysis and update.

Cold Spring Harb Perspect Biol. 5a012641Singh G Pachouri UC Khaidem DC Kundu A Chopra C Singh P.

Mitochondrial DNA damage and diseases.

F1000Research. 4: 176Weinberg SE Sena LA Chandel NS.

Mitochondria in the regulation of innate and adaptive immunity.

Immunity. 42: 406-417Porporato PE Filigheddu N Pedro JMB Kroemer G Galluzzi L.

Mitochondrial metabolism and cancer.

Cell Res. 28: 265-280

Mitochondrial DNA mutations in human disease.

Nat Rev Genet. 6: 389-402

Understanding mitochondrial polymorphisms in cancer.

Cancer Res. 77: 6051-6059Rodríguez-Enríquez S Á Marín-Hernández Gallardo-Pérez JC Pacheco-Velázquez SC Belmont-Díaz JA Robledo-Cadena DX Vargas-Navarro JL Corona de la Peña NA Saavedra E Moreno-Sánchez R

Transcriptional regulation of energy metabolism in cancer cells.

Cells. 8LeBleu VS O'Connell JT Gonzalez Herrera KN Wikman H Pantel K Haigis MC de Carvalho FM Damascena A Domingos Chinen LT Rocha RM Asara JM Kalluri R

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

Nat Cell Biol. 16 (): 992-1003

Sirt1 and the mitochondria.

Mol Cells. 39: 87-95Czarnecka AM Krawczyk T Plak K Klemba A Zdrozny M Arnold RS Kofler B Golik P Szybinska A Lubinski J Mossakowska M Bartnik E Petros JA.

Mitochondrial genotype and breast cancer predisposition.

Oncol Rep. 24: 1521-1534Booker LM Habermacher GM Jessie BC Sun QC Baumann AK Amin M Lim SD Fernandez-Golarz C Lyles RH Brown MD Marshall FF Petros JA.

North American white mitochondrial haplogroups in prostate and renal cancer.

J Urol. 175 (): 468-472Fang H Shen L Chen T He J Ding Z Wei J Qu J Chen G Lu J Bai Y.

Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer.

BMC Cancer. 10: 421-431De Benedictis G Rose G Carrieri G De Luca M Falcone E Passarino G Bonafe M Monti D Baggio G Bertolini S Mari D Mattace R Franceschi C.

Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.

Faseb J. 13: 1532-1536Chocron ES Munkácsy E Pickering AM.

Cause or casualty: the role of mitochondrial DNA in aging and age-associated disease.

Biochim Biophys Acta Mol Basis Dis. 1865: 285-297Chalkia D Chang YC Derbeneva O Lvova M Wang P Mishmar D Liu X Singh LN Chuang LM Wallace DC.

Mitochondrial DNA associations with East Asian metabolic syndrome.

Biochim Biophys Acta Bioenerg. 1859: 878-892Giannoccaro MP La Morgia C Rizzo G Carelli V

Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.

Mov Disord. 32: 346-363Micheloud D Berenguer J Guzmán-Fulgencio M Campos Y García-Álvarez M Catalán P Cosín J Miralles P López JC Resino S.

European mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy.

J Acquir Immune Defic Syndr. 58: 371-378Chen C Ba Y Li D Du X Lia X Yang H An J Xing J Yang H Dong G Guo X

Genetic variations of mitochondrial genome modify risk and prognosis of hepatocellular carcinoma patients.

Clin Res Hepatol Gastroenterol. 41: 378-385Singh L Saini N Pushker N Bakhshi S Sen S Nag TC Kashyap S.

Mutational analysis of the mitochondrial DNA displacement-loop region in human retinoblastoma with patient outcome.

Pathol Oncol Res. 25: 503-512van Ginkel PR Darjatmoko SR Sareen D Subramanian L Bhattacharya S Lindstrom MJ Albert DM Polans AS.

Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction.

Invest Ophthalmol Vis Sci. 49: 1299-1306Jager MJ Magner JA Ksander BR Dubovy SR.

Uveal melanoma cell lines: where do they come from? (An American Ophthalmological Society Thesis).

Trans Am Ophthalmol Soc. 114: T5De Waard-Siebinga I Blom DJ Griffioen M Schrier PI Hoogendoorn E Beverstock G Danen EH Jager MJ.

Establishment and characterization of an uveal-melanoma cell line.

Int J Cancer. 62: 155-161Chen PW Murray TG Uno T Salgaller ML Reddy R Ksander BR.

Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.

Clin Exp Metastasis. 15: 509-518Udar N Atilano SR Memarzadeh M Boyer DS Chwa M Lu S Maguen B Langberg J Coskun P Wallace DC Nesburn AB Khatibi N Hertzog D Le K Hwang D Kenney MC.

Mitochondrial DNA haplogroups associated with age-related macular degeneration.

Invest Ophthalmol Vis Sci. 50: 2966-2974Zaragoza MV Brandon MC Diegoli M Arbustini E Wallace DC.

Mitochondrial cardiomyopathies: how to identify candidate pathogenic mutations by mitochondrial DNA sequencing, MITOMASTER and phylogeny.

Eur J Hum Genet. 19: 200-207Preste R Vitale O Clima R Attimonelli M.

HmtVar: a brand-new resource for human mitochondrial variations and pathogenicity data.

bioRxiv. 355461Guo Z Zhao S Fan H Du Y Zhao Y Wang G.

Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer.

Mitochondrial DNA A DNA Mapp Seq Anal. 27: 4244-4245

Accumulation of mutations over the complete mitochondrial genome in tobacco-related oral cancer from northeast India.

Mitochondrial DNA. 24: 432-439Shu HY Li HC Xie WQ Ni B Zhou HY.

Mitochondrial DNA variations in tongue squamous cell carcinoma.

Biomed Rep. 10: 23-28Thèves C Keyser-Tracqui C Crubézy E Salles JP Ludes B Telmon N.

Detection and quantification of the age-related point mutation A189G in the human mitochondrial DNA.

J Forensic Sci. 51: 865-873Lacan M Thèves C Amory S Keyser C Crubézy E Salles JP Ludes B Telmon N

Detection of the A189G mtDNA heteroplasmic mutation in relation to age in modern and ancient bones.

Int J Legal Med. 123: 161-167Coskun PE Beal MF Wallace DC.

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.

Proc Natl Acad Sci USA. 101: 10726-10731Ebner S Lang R Mueller EE Eder W Oeller M Moser A Koller J Paulweber B Mayr JA Sperl W Kofler B.

Mitochondrial haplogroups, control region polymorphisms and malignant melanoma: a study in middle European Caucasians.

PLoS One. 6: e27192Kenney MC Chwa M Atilano SR Falatoonzadeh P Ramirez C Malik D Tarek M Del Carpio JC Nesburn AB Boyer DS Kuppermann BD Vawter MP Jazwinski SM Miceli MV Wallace DC Udar N.

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

Biochim Biophys Acta. 1842: 208-219Warburg O Wind F Negelein E.

The metabolism of tumors in the body.

J Gen Physiol. 8: 519-530

Metabolic pathways of the Warburg effect in health and disease: perspectives of choice, chain or chance.

Int J Mol Sci. 18Xiao J Cohen P Stern MC Odedina F Carpten J Reams R.

Mitochondrial biology and prostate cancer ethnic disparity.

Carcinogenesis. 39: 1311-1319Roostalu U Kutuev I Loogväli E-L Metspalu E Tambets K Reidla M Khusnutdinova E Usanga E Kivisild T Villems R.

Origin and expansion of Haplogroup H, the dominant human mitochondrial DNA lineage in west Eurasia: the near eastern and Caucasian perspective.

Mol Biol Evol. 24: 436-448Kenney MC Chwa M Atilano SR Pavlis JM Falatoonzadeh P Ramirez C Malik D Hsu T Woo G Soe K Nesburn AB Boyer DS Kuppermann BD Jazwinski SM Miceli MV Wallace DC Udar N.

Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration.

PLoS One. 8: e54339Scheid AD Beadnell TC Welch DR.

The second genome: effects of the mitochondrial genome on cancer progression.

Adv Cancer Res. 142: 63-105Malik D Hsu T Falatoonzadeh P Cáceres-del-Carpio J Tarek M Chwa M Atilano SR Ramirez C Nesburn AB Boyer DS Kuppermann BD Jazwinski SM Miceli MV Wallace DC Udar N Kenney MC.

Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases.

PLoS One. 9: e99003Li H Slone J Fei L Huang T.

Mitochondrial DNA variants and common diseases: a mathematical model for the diversity of age-related mtDNA mutations.

Cells. 8: 608Thyagarajan B Wang R Nelson H Barcelo H Koh WP Yuan JM.

Mitochondrial DNA copy number is associated with breast cancer risk.

PLoS One. 8: e65968

MtDNA as a cancer marker: a finally closed chapter?.

Curr Genom. 18: 255-267Veronese N Stubbs B Koyanagi A Vaona A Demurtas J Schofield P Maggi S.

Mitochondrial genetic haplogroups and cardiovascular diseases: data from the osteoarthritis initiative.

PLoS One. 14e0213656Beadnell TC Scheid AD Vivian CJ Welch DR.

Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer.

Cancer Metastasis Rev. 37: 615-632Olsen JH Friis S Frederiksen K McLaughlin JK Mellemkjaer L Møller H.

Atypical cancer pattern in patients with Parkinson's disease.

Br J Cancer. 92: 201-205Young MJ Jayaprakash AD Young CKJ.

Analysis of mitochondrial DNA polymorphisms in the human cell lines HepaRG and SJCRH30.

Int J Mol Sci. 20Sequeira A Rollins B Magnan C van Oven M Baldi P Myers RM Barchas JD Schatzberg AF Watson SJ Akil H Bunney WE Vawter MP.

Mitochondrial mutations in subjects with psychiatric disorders.

PLoS One. 10e0127280Weigl S Paradiso A Tommasi S.

Mitochondria and familial predisposition to breast cancer.

Curr Genom. 14: 195-203Duan M Chen L Ge Q Lu N Li J Pan X Qiao Y Tu J Lu Z.

Evaluating heteroplasmic variations of the mitochondrial genome from whole genome sequencing data.

Gene. 699: 145-154Zhang Z Gao Z Rajthala S Sapkota D Dongre H Parajuli H Suliman S Das R Li L Bindoff LA Costea DE Liang X

Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.

Cell Mol Life Sci. 77: 1115-1133Shoffner JM Brown MD Torroni A Lott MT Cabell MF Mirra SS Beal MF Yang CC Gearing M Salvo R et al.

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.

Genomics. 17: 171-184Fernández-Caggiano M Barallobre-Barreiro J Rego-Pérez I Crespo-Leiro MG Paniagua MJ Grillé Z Blanco FJ Doménech N.

Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy.

PLoS One. 7: e44128Kenney MC Chwa M Atilano SR Falatoonzadeh P Ramirez C Malik D Tarek M Cáceres-del-Carpio J Nesburn AB Boyer DS Kuppermann BD Vawter M Jazwinski SM Miceli M Wallace DC Udar N.

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions.

Hum Mol Genet. 23: 3537-3551Mastropasqua F Girolimetti G Shoshan M.

PGC1α: friend or foe in cancer?.

Genes. 9Giallongo S Di Rosa M Caltabiano R Longhitano L Reibaldi M Distefano A Lo Re O Amorini AM Puzzo L Salvatorelli L Palmucci S Tibullo D Russo A Longo A Lazzarino G Li Volti G Vinciguerra M

Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells.

Aging. 12: 9745-9760

Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma.

Sci Rep. 6: 22622Halfed DG Zoroquiain P Wood HA Blanco P Al-Saati N Aldrees S Bravo-Filho V Burnier MN.

SIRT2 expression is higher in uveal melanoma than in ocular melanocytes.

Ocul Oncol Pathol. 2: 100-104Singh MK Singh L Chosdol K Pushker N Meel R Bakhshi S Sen S Kashyap S.

Clinicopathological relevance of NFκB1/p50 nuclear immunoreactivity and its relationship with the inflammatory environment of uveal melanoma.

Exp Mol Pathol. 111104313Rodriguez DA Sanchez MI Decatur CL Correa ZM Martin ER Harbour JW.

Impact of genetic ancestry on prognostic biomarkers in uveal melanoma.

Cancers. 12: 3208Porporato PE Payen VL Baselet B Sonveaux P.

Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism.

Cell Mol Life Sci. 73: 1349-1363Singh KK Ayyasamy V Owens KM Koul MS Vujcic M.

Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis.

J Hum Genet. 54: 516-524