Siegel RL Miller KD Jemal A.

Cancer statistics.

CA-Cancer J. Clin. 2018; 68 (2018): 7-30View in Article Scopus (4825) PubMed Crossref Google ScholarKlein MJ Siegal GP.

Osteosarcoma: anatomic and histologic variants.

Am J Clin Pathol. 2006; 125: 555-581View in Article PubMed Crossref Google ScholarTeicher BA.

Searching for molecular targets in sarcoma.

Biochem Pharmacol. 2012; 84: 1-10View in Article Scopus (47) PubMed Crossref Google ScholarKansara Maya Teng Michele W Smyth Mark J et al.

Translational biology of osteosarcoma.

Nat. Rev. Cancer. 2014; 14: 722-735View in Article Scopus (503) PubMed Crossref Google ScholarGianferante D.M Mirabello L Savage S.A.

Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy.

Nat Rev Endocrinol. 2017; 13: 480View in Article Scopus (153) PubMed Crossref Google ScholarKovac M Blattmann C Ribi S et al.

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.

Nat Commun. 2015; 6: 1-9View in Article Scopus (147) Crossref Google ScholarPerry J A Kiezun A Tonzi P et al.

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.

P. Natl. Acad. Sci. USA. 2014; 111: E5564-E5573View in Article Scopus (229) PubMed Crossref Google ScholarWang D Niu X Wang Z et al.

Multiregion sequencing reveals the genetic heterogeneity and evolutionary history of osteosarcoma and matched pulmonary metastases.

Cancer Res. 2019; 79: 7-20View in Article Scopus (39) PubMed Crossref Google ScholarXu H Zhu X Bao H et al.

Genetic and clonal dissection of osteosarcoma progression and lung metastasis.

Int. J. Cancer. 2018; 143: 1134-1142View in Article Scopus (17) PubMed Crossref Google ScholarNCCN Clinical Practice Guidelines in Oncology

Bone Cancer (Version 1, 2021).

2020 (Nov 20)View in Article Google ScholarSuehara Y Alex D Bowman A et al.

Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations.

Clin Cancer Res. 2019; 25: 6346-6356View in Article Scopus (19) PubMed Crossref Google ScholarChakravarty D Gao J Phillips S et al.

OncoKB: a precision oncology knowledge base.

JCO precision oncology. 2017; 1: 1-16View in Article Scopus (595) Crossref Google ScholarEnneking WF Spanier SS Goodman MA.

A system for the surgical staging of musculoskeletal sarcoma.

Clin Orthop. Relat. R. 1980; 153: 106-120View in Article PubMed Google ScholarSanchez-Vega F Mina M Armenia J et al.

Oncogenic signaling pathways in the cancer genome atlas.

Cell. 2018; 173: 321-337View in Article Scopus (672) PubMed Abstract Full Text Full Text PDF Google ScholarZehir A Benayed R Shah R H et al.

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Nat Med. 2017; 23: 703View in Article Scopus (1205) PubMed Crossref Google ScholarAlexandrov L B Nik-Zainal S Wedge D C et al.

Signatures of mutational processes in human cancer.

Nature. 2013; 500: 415-421View in Article Scopus (4824) PubMed Crossref Google ScholarKnijnenburg T A Wang L Zimmermann M T et al.

Genomic and molecular landscape of DNA damage repair deficiency across The Cancer Genome Atlas.

Cell Rep. 2018; 23: 239-254View in Article Scopus (231) PubMed Abstract Full Text Full Text PDF Google ScholarTeo M Y Seier K Ostrovnaya I et al.

Alterations in DNA damage response and repair genes as potential marker of clinical benefit from PD-1/PD-L1 blockade in advanced urothelial cancers.

J Clin Oncol. 2018; 36: 1685View in Article Scopus (193) PubMed Crossref Google ScholarHuang Y Wang J Jia P et al.

Clonal architectures predict clinical outcome in clear cell renal cell carcinoma.

Nat Commun. 2019; 10: 1-10View in Article Scopus (39) PubMed Crossref Google ScholarMody R J Wu Y M Lonigro R J et al.

Integrative clinical sequencing in the management of refractory or relapsed cancer in youth.

JAMA. 2015; 314: 913-925View in Article Scopus (215) PubMed Crossref Google ScholarTurajlic S Xu H Litchfield K et al.

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal.

Cell. 2018; 173: 595-610View in Article Scopus (190) PubMed Abstract Full Text Full Text PDF Google ScholarChen X Bahrami A Pappo A et al.

Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

Cell Rep. 2014; 7: 104-112View in Article Scopus (341) PubMed Abstract Full Text Full Text PDF Google ScholarKim T M Jung S H An C H et al.

Subclonal genomic architectures of primary and metastatic colorectal cancer based on intratumoral genetic heterogeneity.

Clin Cancer Res. 2015; 21: 4461-4472View in Article Scopus (117) PubMed Crossref Google ScholarZhang K Dong C Chen M et al.

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.

Theranostics. 2020; 10: 411View in Article Scopus (17) PubMed Crossref Google ScholarReimann E Kõks S Ho X D et al.

Whole exome sequencing of a single osteosarcoma case—integrative analysis with whole transcriptome RNA-seq data.

Hum. Genomics. 2014; 8: 20View in Article PubMed Google ScholarBacci G Rocca M Salone M C et al.

High-grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions.

J Surg Oncol. 2008; 98: 415-420View in Article Scopus (130) PubMed Crossref Google ScholarNaxerova K Jain R K

Using tumour phylogenetics to identify the roots of metastasis in humans.

Nat Rev Clin Oncol. 2015; 12: 258View in Article Scopus (87) PubMed Crossref Google ScholarBehjati S Tarpey P S Haase K et al.

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

Nat Commun. 2017; 8: 1-8View in Article Scopus (96) PubMed Crossref Google ScholarSayles L C Breese M R Koehne A L et al.

Genome-informed targeted therapy for osteosarcoma.

Cancer Discov. 2019; 9: 46-63View in Article PubMed Google ScholarKarim R Z Tse G M K Putti T C et al.

The significance of the Wnt pathway in the pathology of human cancers.

Pathology. 2004; 36: 120-128View in Article Scopus (229) PubMed Abstract Full Text PDF Google ScholarPark H.W. Guan K.-L.

Regulation of the Hippo pathway and implications for anticancer drug development.

Trends Pharmacol Sci. 2013; 34: 581-589View in Article PubMed Abstract Full Text Full Text PDF Google ScholarRawlings J.S Rosler K.M Harrison D.A

The JAK/STAT signaling pathway.

J Cell Sci. 2004; 117: 1281-1283View in Article Scopus (1071) PubMed Crossref Google ScholarCarter S.L. et al.

Absolute quantification of somatic DNA alterations in human cancer.

Nat Biotechnol. 2012; 30: 413-421View in Article Scopus (971) PubMed Crossref Google ScholarMa H Seebacher N.A Hornicek F J et al.

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma.

EBioMedicine. 2019; 39: 182-193View in Article PubMed Abstract Full Text Full Text PDF Google ScholarIngham M Schwartz G K

Cell-cycle therapeutics come of age.

J Clin Oncol. 2017; 35: 2949View in Article