Autonomic nervous system dysfunction correlates with microvascular damage in systemic sclerosis patients

1. LeRoy, EC, Black, C, Fleischmajer, R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15(2): 202–205.
Google Scholar | Medline2. Herrick, AL, Wigley, FM. Raynaud’s phenomenon. Best Pract Res Clin Rheumatol 2020; 34: 101474.
Google Scholar | Crossref | Medline3. LeRoy, EC. Systemic sclerosis. A vascular perspective. Rheum Dis Clin North Am 1996; 22: 675–694.
Google Scholar | Crossref | Medline4. Kahaleh, MB. Raynaud’s phenomenon and vascular disease in scleroderma. Curr Opin Rheumatol 1994; 6: 621–627.
Google Scholar | Crossref | Medline5. Dessein, PH, Joffe, BI, Metz, RM, et al. Autonomic dysfunction in systemic sclerosis: sympathetic overactivity and instability. Am J Med 1992; 93: 143–150.
Google Scholar | Crossref | Medline6. Poanta, L, Dadu, R, Tiboc, C, et al. Systolic and diastolic function in patients with systemic sclerosis. Eur J Intern Med 2009; 20: 378–382.
Google Scholar | Crossref | Medline7. Allanore, Y, Meune, C, Kahan, A. Outcome measures for heart involvement in systemic sclerosis. Rheumatology 2008; 47(suppl. 5): v51–v53.
Google Scholar | Crossref | Medline8. Kahan, A, Coghlan, G, McLaughlin, V. Cardiac complications of systemic sclerosis. Rheumatology 2009; 48(suppl. 3): iii45–iii48.
Google Scholar | Crossref | Medline9. Ferri, C, Giuggioli, D, Sebastiani, M, et al. Heart involvement and systemic sclerosis. Lupus 2005; 14: 702–707.
Google Scholar | SAGE Journals10. Cozzolino, D, Naclerio, C, Iengo, R, et al. Cardiac autonomic dysfunction precedes the development of fibrosis in patients with systemic sclerosis. Rheumatology 2002; 41: 586–588.
Google Scholar | Crossref | Medline11. Grossman, P, Karemaker, J, Wieling, W. Prediction of tonic parasympathetic cardiac control using respiratory sinus arrhythmia: the need for respiratory control. Psychophysiology 1991; 28: 210–216.
Google Scholar | Crossref12. Kleiger, RE, Bigger, JT, Bosner, MS, et al. Stability over time of variables measuring heart rate variability in normal subjects. Am J Cardiol 1991; 68: 626–630.
Google Scholar | Crossref | Medline13. Cerinic, MM, Generini, S, Pignone, A, et al. The nervous system in systemic sclerosis (scleroderma). Clinical features and pathogenetic mechanisms. Rheum Dis Clin North Am 1996; 22: 879–892.
Google Scholar | Crossref | Medline14. Herrick, AL. Neurological involvement in systemic sclerosis. Br J Rheumatol 1995; 34(11): 1007–1008.
Google Scholar | Crossref | Medline15. Kahaleh, B, Matucci-Cerinic, M. Raynaud’s phenomenon and scleroderma. Dysregulated neuroendothelial control of vascular tone. Arthritis Rheum 1995; 38: 1–4.
Google Scholar | Crossref | Medline16. Van den Hoogen, F, Khanna, D, Fransen, J, et al. Classification criteria for systemic sclerosis: an ACR-EULAR collaborative initiative. Arthritis Rheum 2013; 65: 2737–2747.
Google Scholar | Crossref | Medline17. Valentini, G, Della Rossa, A, Bombardieri, S, et al. European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes. Ann Rheum Dis 2001; 60(6): 592–598.
Google Scholar | Crossref | Medline18. Maricq, HR, Harper, FE, Khan, MM, et al. Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease. Clin Exp Rheumatol 1983; 1: 195–205.
Google Scholar | Medline19. Maricq, HR. Wide-field capillary microscopy: technique and rating scale for abnormalities seen in scleroderma and related disorder. Arthritis Rheum 1981; 24: 1159–1165.
Google Scholar | Crossref | Medline20. Cutolo, M, Sulli, A, Pizzorni, C, et al. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000; 27: 155–160.
Google Scholar | Medline21. Lee, P, Leung, FY, Alderdice, C, et al. Nailfold capillary microscopy in the connective tissue diseases: a semiquantitative assessment. J Rheumatol 1983; 10(6): 930–938.
Google Scholar | Medline22. Emrani, Z, Karbalaie, A, Fatemi, A, et al. Capillary density: an important parameter in nailfold capillaroscopy. Microvasc Res 2017; 109: 7–18.
Google Scholar | Crossref | Medline23. Cutolo, M, Sulli, A, Secchi, ME, et al. Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. A future tool for the analysis of microvascular heart involvement? Rheumatology 2006; 45(suppl. 4): iv43–iv46.
Google Scholar | Crossref | Medline24. Poncelet, AN, Connolly, MK. Peripheral neuropathy in scleroderma. Muscle Nerve 2003; 28(3): 330–335.
Google Scholar | Crossref | Medline25. Spallone, V, Morganti, R, D’Amato, C, et al. Validation of DN4 as a screening tool for neuropathic pain in painful diabetic polyneuropathy. Diabet Med 2012; 29(5): 578–585.
Google Scholar | Crossref | Medline26. Pop-Busui, R, Boulton, AJ, Feldman, EL, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care 2017; 40(1): 136–154.
Google Scholar | Crossref | Medline27. Mete, T, Aydin, Y, Saka, M, et al. Comparison of efficiencies of Michigan neuropathy screening instrument, neurothesiometer, and electromyography for diagnosis of diabetic neuropathy. Int J Endocrinol 2013; 2013: 821745.
Google Scholar | Crossref | Medline28. Ferri, C, Emdin, M, Giuggioli, D, et al. Autonomic dysfunction in systemic sclerosis: time and frequency domain 24 hour heart rate variability analysis. Br J Rheumatol 1997; 36: 669–676.
Google Scholar | Crossref | Medline29. Pancera, P, Sansone, S, Presciuttini, B, et al. Autonomic nervous system dysfunction in sclerodermic and primary Raynaud’s phenomenon. Clin Sci 1999; 96: 49–57.
Google Scholar | Crossref30. Klimiuk, PS, Taylor, L, Baker, RD, et al. Autonomic neuropathy in systemic sclerosis. Ann Rheum Dis 1988; 47: 542–545.
Google Scholar | Crossref | Medline31. Sonnex, C, Paice, E, White, AG. Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients. Ann Rheum Dis 1986; 45: 957–960.
Google Scholar | Crossref | Medline32. Amaral, TN, Peres, FA, Lapa, AT, et al. Neurologic involvement in scleroderma: a systematic review. Semin Arthritis Rheum 2013; 43: 335–347.
Google Scholar | Crossref | Medline33. Schady, W, Sheard, A, Hassell, A, et al. Peripheral nerve dysfunction in scleroderma. Q J Med 1991; 80: 661–675.
Google Scholar | Medline34. Straub, RH, Zeuner, M, Lock, G, et al. Autonomic and sensorimotor neuropathy in patients with systemic lupus erythematosus and systemic sclerosis. J Rheumatol 1996; 23: 87–92.
Google Scholar | Medline35. McLeod, JG, Tuck, RR. Disorders of the autonomic nervous system: part 1. Pathophysiology and clinical features. Ann Neurol 1987; 21: 419–430.
Google Scholar | Crossref | Medline36. Ewing, DJ, Clarke, BF. Autonomic neuropathy: its diagnosis and prognosis. Clin Endocrinol Metab 1986; 15: 855–888.
Google Scholar | Crossref | Medline37. Wieling, W, Van Lieshout, JJ. The assessment of cardiovascular reflex activity: standardization is needed. Diabetologia 1990; 33: 182–183.
Google Scholar | Crossref | Medline38. Lawrence, GP, Home, PD, Murray, A. Repeatability of measurements and sources of variability in tests of cardiovascular autonomic function. Br Heart J 1992; 68: 205–211.
Google Scholar | Crossref | Medline39. Suarez-Almazor, ME, Bruera, E, Russel, AS. Normal cardiovascular autonomic function in patients with systemic sclerosis (CREST variant). Ann Rheum Dis 1988; 47: 672–674.
Google Scholar | Crossref | Medline40. Hermosillo, A, Ortiz, R, Dabague, J, et al. Autonomic dysfunction in diffuse scleroderma vs CREST: an assessment by computerized heart rate variability. J Rheumatol 1994; 21: 1849–1854.
Google Scholar | Medline41. Di Franco, M, Paradiso, M, Riccieri, V, et al. Autonomic dysfunction and microvascular damage in systemic sclerosis. Clin Rheumatol 2007; 26(8): 1278–1283.
Google Scholar | Crossref | Medline42. Herrick, AL. Vascular function in systemic sclerosis. Curr Opin Rheumatol 2000; 12: 527–533.
Google Scholar | Crossref | Medline43. Stacher, G, Merio, R, Budka, C, et al. Cardiovascular autonomic function, autoantibodies, and esophageal motor activity in patients with systemic sclerosis and mixed connective tissue disease. J Rheumatol 2000; 27: 692–697.
Google Scholar | Medline44. Terenghi, G, Bunker, CB, Liu, YF, et al. Image analysis quantification of peptide-immunoreactive nerves in the skin of patients with Raynaud’s phenomenon and systemic sclerosis. J Pathol 1991; 164: 245–252.
Google Scholar | Crossref | Medline45. Othman, KM, Assaf, NY, Farouk, HM, et al. Autonomic dysfunction predicts early cardiac affection in patients with systemic sclerosis. Clin Med Insights Arthritis Musculoskelet Disord 2010; 3: 43–54.
Google Scholar | SAGE Journals46. Ferri, C, Bernini, L, Bongiorni, MG, et al. Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients. Arthritis Rheum 1985; 28: 1259–1266.
Google Scholar | Crossref | Medline

Comments (0)

No login
gif