This study analyzed the determinants of weight gain among participants initiating an automated insulin delivery (AID) system.

In this observational study, we evaluated 928 persons with type 1 diabetes initiating an insulin pump therapy, including 467 with AID, 98 with pumps with predictive low-glucose suspend (PLGS) algorithm and 363 initiating a sensor-augmented pump (SAP).

After 3 months, median (95CI) TIR increased from 50.69 % [49.2–52.3] to 67.9 % [66.7–69.1] in the AID group and HbA1c levels showed a mean reduction of 0.82 %. AID resulted in equivalent body weight gain to SAP and PLGS despite significant improvements in glucose control. Multivariable analysis revealed that weight gain was linked to baseline HbA1C (P < 0.001) and age but not to the type of pump system. During follow-up, percentage increase in body weight at 12 months were similar between groups

In persons with T1D, AID did not increase weight gain in comparison to other pump systems.