Li S, Yang H, Guo Y, Wei F, Yang X, Li D, et al. Comparative efficacy and safety of urate-lowering therapy for the treatment of hyperuricemia: a systematic review and network meta-analysis. Sci Rep. 2016;6:33082.

CAS  Google Scholar 

Bernal JA, Quilis N, Andrés M, Sivera F, Pascual E. Gout: optimizing treatment to achieve a disease cure. Ther Adv Chronic Dis. 2016;7:135–44.

CAS  Google Scholar 

Eisenberg R. Why can’t we find a new treatment for SLE? J Autoimmun. 2009;32:223–30.

CAS  Google Scholar 

Nagy G, Roodenrijs NM, Welsing PM, Kedves M, Hamar A, van der Goes MC, et al. EULAR definition of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2021;80:31–5.

Google Scholar 

Singla S, Ribeiro A, Torgutalp M, Mease PJ, Proft F. Difficult-to-treat psoriatic arthritis (D2T PsA): a scoping literature review informing a GRAPPA research project. RMD Open. 2024;10:e003809.

Google Scholar 

Rai SK, Choi HK, Choi SHJ, Townsend AF, Shojania K, De Vera MA. Key barriers to gout care: a systematic review and thematic synthesis of qualitative studies. Rheumatol Oxf Engl. 2018;57:1282–92.

Google Scholar 

Krishnan E, Lienesch D, Kwoh CK. Gout in ambulatory care settings in the united States. J Rheumatol. 2008;35:498–501.

Google Scholar 

DiGiovanni BF, Sundem LT, Southgate RD, Lambert DR. Musculoskeletal medicine is underrepresented in the American medical school clinical curriculum. Clin Orthop. 2016;474:901–7.

Google Scholar 

Peeler J. Addressing musculoskeletal curricular inadequacies within undergraduate medical education. BMC Med Educ. 2024;24:845.

Google Scholar 

Kwok TSH, Bajaj S, Papneja T, Ahluwalia V, Choy G, Joshi R. Diagnostic accuracy and trajectories of referrals for gout to rheumatology. Joint Bone Spine. 2025;92:105919.

Google Scholar 

Rai SK, Burns LC, De Vera MA, Haji A, Giustini D, Choi HK. The economic burden of gout: A systematic review. Semin Arthritis Rheum. 2015;45:75–80.

Google Scholar 

Chandratre P, Roddy E, Clarson L, Richardson J, Hider SL, Mallen CD. Health-related quality of life in gout: a systematic review. Rheumatol Oxf Engl. 2013;52:2031–40.

CAS  Google Scholar 

Vargas-Santos AB, Neogi T, da, Castelar-Pinheiro R, Kapetanovic G, Turkiewicz MC. A. Cause-Specific Mortality in Gout: Novel Findings of Elevated Risk of Non-Cardiovascular-Related Deaths. Arthritis Rheumatol Hoboken NJ. 2019;71:1935–42.

GBD 2021 Gout Collaborators. Global, regional, and National burden of gout, 1990–2020, and projections to 2050: a systematic analysis of the global burden of disease study 2021. Lancet Rheumatol. 2024;6:e507–17.

Google Scholar 

Fisher MC, Rai SK, Lu N, Zhang Y, Choi HK. The unclosing premature mortality gap in gout: a general population-based study. Ann Rheum Dis. 2017;76:1289–94.

Google Scholar 

Grimshaw JM, Eccles MP, Lavis JN, Hill SJ, Squires JE. Knowledge translation of research findings. Implement Sci IS. 2012;7:50.

Google Scholar 

Wenger NS, Shekelle PG. Assessing care of vulnerable elders: ACOVE project overview. Ann Intern Med. 2001;135:642–6.

CAS  Google Scholar 

Donabedian A. Evaluating the quality of medical care. 1966. Milbank Q. 2005;83:691–729.

Pincus T. Documenting quality management in rheumatic disease: are patient questionnaires the best (and only) method? Arthritis Care Res. 1996;9:339–48.

CAS  Google Scholar 

Shekelle PG, MacLean CH, Morton SC, Wenger NS. Acove quality indicators. Ann Intern Med. 2001;135:653–67.

CAS  Google Scholar 

Mikuls TR, MacLean CH, Olivieri J, Patino F, Allison JJ, Farrar JT, et al. Quality of care indicators for gout management. Arthritis Rheum. 2004;50:937–43.

Google Scholar 

Kwok TSH, Kuriya B, Hawker G, Eder L, Li P, Choy G et al. Adherence and Treat-to-Target benchmarks in older adults with gout initiating Urate-Lowering therapy in ontario, canada: A Population-Based study. Arthritis Care Res. 2024; 76:1379-1389 https://pubmed.ncbi.nlm.nih.gov/38831665/

Kwok TSH, Kuriya B, Hawker G, Li P, Choy G, Widdifield J. Serum urate monitoring among older adults with gout: initiating urate-Lowering therapy in ontario, Canada. Arthritis Care Res. 2023;75:2463-2471. https://pubmed.ncbi.nlm.nih.gov/37248652/

Singh JA, Hodges JS, Toscano JP, Asch SM. Quality of care for gout in the US needs improvement. Arthritis Rheum. 2007;57:822–9.

Google Scholar 

Mikuls TR, Farrar JT, Bilker WB, Fernandes S, Saag KG. Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK general practice research database (GPRD). Rheumatol Oxf Engl. 2005;44:1038–42.

CAS  Google Scholar 

Saag KG, Yazdany J, Alexander C, Caplan L, Coblyn J, Desai SP, et al. Defining quality of care in rheumatology: the American college of rheumatology white paper on quality measurement. Arthritis Care Res. 2011;63:2–9.

Google Scholar 

FitzGerald JD, Mikuls TR, Neogi T, Singh JA, Robbins M, Khanna PP, et al. Development of the American college of rheumatology electronic clinical quality measures for gout. Arthritis Care Res. 2018;70:659–71.

Google Scholar 

Yazdany J, Bansback N, Clowse M, Collier D, Law K, Liao KP, et al. Rheumatology informatics system for effectiveness: A National informatics-Enabled registry for quality improvement. Arthritis Care Res. 2016;68:1866–73.

Google Scholar 

Qaseem A, Harris RP, Forciea MA, Clinical Guidelines Committee of the American College of Physicians, Denberg TD, Barry MJ, et al. Management of acute and recurrent gout: A clinical practice guideline from the American college of physicians. Ann Intern Med. 2017;166:58–68.

Google Scholar 

Richette P, Doherty M, Pascual E, Barskova V, Becce F, Castañeda-Sanabria J, et al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017;76:29–42.

CAS  Google Scholar 

Hui M, Carr A, Cameron S, Davenport G, Doherty M, Forrester H, et al. The British society for rheumatology guideline for the management of gout. Rheumatol Oxf Engl. 2017;56:e1–20.

CAS  Google Scholar 

Timsans J, Palomäki A, Kauppi M. Gout and hyperuricemia: A narrative review of their comorbidities and clinical implications. J Clin Med. 2024;13:7616.

CAS  Google Scholar 

Jordan KM, Cameron JS, Snaith M, Zhang W, Doherty M, Seckl J, et al. British society for rheumatology and British health professionals in rheumatology guideline for the management of gout. Rheumatol Oxf Engl. 2007;46:1372–4.

Google Scholar 

Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, et al. EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR standing committee for international clinical studies including therapeutics (ESCISIT). Ann Rheum Dis. 2006;65:1312–24.

CAS  Google Scholar 

FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, et al. 2020 American college of rheumatology guideline for the management of gout. Arthritis Care Res. 2020;72:744–60.

Google Scholar 

McCormick N, Yokose C, Challener GJ, Joshi AD, Tanikella S, Choi HK. Serum urate and recurrent gout. JAMA. 2024;331:417–24.

CAS  Google Scholar 

Taylor TH, Mecchella JN, Larson RJ, Kerin KD, Mackenzie TA. Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med. 2012;125:1126–e11347.

CAS  Google Scholar 

Hill EM, Sky K, Sit M, Collamer A, Higgs J. Does starting allopurinol prolong acute treated gout? A randomized clinical trial. J Clin Rheumatol Pract Rep Rheum Musculoskelet Dis. 2015;21:120–5.

Google Scholar 

Densen P. Challenges and opportunities facing medical education. Trans Am Clin Climatol Assoc. 2011;122:48–58.

Google Scholar 

Neogi T, Jansen TLTA, Dalbeth N, Fransen J, Schumacher HR, Berendsen D, et al. 2015 gout classification criteria: an American college of rheumatology/european league against rheumatism collaborative initiative. Ann Rheum Dis. 2015;74:1789–98.

CAS  Google Scholar 

Kwok TSH, Xu VYY, Lake SL, Gout. CMAJ Can Med Assoc J J Assoc Medicale Can. 2021;193:E171.

Google Scholar 

MacFarlane LA, Liu C-C, Solomon DH, Kim SC. Validation of claims-based algorithms for gout flares. Pharmacoepidemiol Drug Saf. 2016;25:820–6.

Google Scholar 

Harrold LR, Saag KG, Yood RA, Mikuls TR, Andrade SE, Fouayzi H, et al. Validity of gout diagnoses in administrative data. Arthritis Rheum. 2007;57:103–8.

Google Scholar 

Singh JA. Veterans affairs databases are accurate for gout-related health care utilization: a validation study. Arthritis Res Ther. 2013;15:R224.

Google Scholar 

Dehlin M, Landgren AJ, Bergsten U, Jacobsson LTH. The validity of gout diagnosis in primary care: results from a patient survey. J Rheumatol. 2019;46:1531–4.

Google Scholar 

Mikuls TR, Soto Q, Petro A, Helget L, Roul P, Sayles H, et al. Comparison of rates of lower extremity amputation in patients with and without gout in the US department of veterans affairs health system. JAMA Netw Open. 2022;5:e2142347.

Google Scholar 

Bowen S, Kreindler SA. Indicator madness: a cautionary reflection on the use of indicators in healthcare. Healthc Policy Polit Sante. 2008;3:41–8.

Google Scholar 

Stamp LK, Farquhar H, Pisaniello HL, Vargas-Santos AB, Fisher M, Mount DB, et al. Management of gout in chronic kidney disease: a G-CAN consensus statement on the research priorities. Nat Rev Rheumatol. 2021;17:633–41.

Google Scholar 

Dalbeth N, Gosling AL, Gaffo A, Abhishek A, Gout. Lancet Lond Engl. 2021;397:1843–55.

CAS  Google Scholar 

Rashid N, Coburn BW, Wu Y-L, Cheetham TC, Curtis JR, Saag KG, et al. Modifiable factors associated with allopurinol adherence and outcomes among patients with gout in an integrated healthcare system. J Rheumatol. 2015;42:504–12.

Google Scholar 

Corbett EJM, Pentony P, McGill NW. Achieving serum urate targets in gout: an audit in a gout-oriented rheumatology practice. Int J Rheum Dis. 2017;20:894–7.

Google Scholar 

Singh JA, Richman J, Yang S, Bridges SL, Saag K. Allopurinol adherence and its predictors in gout: a National cohort study in US veterans. Lancet Rheumatol. 2020;2:e281–91.

Google Scholar 

Mikuls TR, Curtis JR, Allison JJ, Hicks RW, Saag KG. Medication errors with the use of allopurinol and colchicine: a retrospective study of a national, anonymous Internet-accessible error reporting system. J Rheumatol. 2006;33:562–6.

Google Scholar 

Anghel LA, Farcas AM, Oprean RN. An overview of the common methods used to measure treatment adherence. Med Pharm Rep. 2019;92:117–22.

Google Scholar 

Bonafede M, Johnson BH, Tang DH, Shah N, Harrison DJ, Collier DH. Etanercept-Methotrexate combination therapy initiators have greater adherence and persistence than triple therapy initiators with rheumatoid arthritis. Arthritis Care Res. 2015;67:1656–63.

CAS  Google Scholar 

Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health J Int Soc Pharmacoeconomics Outcomes Res. 2008;11:44–7.

Google Scholar 

McDonough RP. Identifying and resolving medication nonadherence. Pharm Today. 2015;21:44.

Google Scholar 

Yin R, Li L, Zhang G, Cui Y, Zhang L, Zhang Q, et al. Rate of adherence to urate-lowering therapy among patients with gout: a systematic review and meta-analysis. BMJ Open. 2018;8:e017542.

Google Scholar 

De Vera MA, Marcotte G, Rai S, Galo JS, Bhole V. Medication adherence in gout: a systematic review. Arthritis Care Res. 2014;66:1551–9.