Three studies were included in the systematic review and meta-analysis. Adjunctive Aloe Vera treatment reduced probing pocket depth (PPD), with MD = −0.47 (−0.78/−0.16) at 3 months, MD = −0.29 (−0.53/−0.06) at 6 months, and MD: −1.06 (−2.04/−0.08) at 12 months, compared to the control group. Overall differences for clinical attachment level (CAL) were found to be −0.56 (−0.85/−0.27) at 6 months and −0.98 (−1.28/−0.68) at 12 months, which indicated a statistically significant result favoring the test group over the control group. No significant differences were observed in reducing plaque index (PI), bleeding index (BI) at 6 months and CAL at 3 months in the local administration of Aloe Vera to SRP. Adjunctive Aloe Vera treatment reduced BI (MD: −0.40; −0.62/−0.18) at 12 months with respect to the control group.