2. Park SH, Kang MJ, Yun EH, Jung KW. Epidemiology of gastric cancer in Korea: trends in incidence and survival based on Korea Central Cancer Registry Data (1999-2019). J Gastric Cancer 2022;22:160–168.

3. Haque E, Esmail A, Muhsen I, Salah H, Abdelrahim M. Recent trends and advancements in the diagnosis and management of gastric cancer. Cancers (Basel) 2022;14:5615.

4. Conti CB, Agnesi S, Scaravaglio M, et al. Early gastric cancer: update on prevention, diagnosis and treatment. Int J Environ Res Public Health 2023;20:2149.

5. Yang J, Zhou X, Liu X, Ling Z, Ji F. Role of the gastric microbiome in gastric cancer: from carcinogenesis to treatment. Front Microbiol 2021;12:641322.

6. Park JY, Seo H, Kang CS, et al. Dysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis. Sci Rep 2022;12:4285.

7. Yang J, Shin TS, Kim JS, Jee YK, Kim YK. A new horizon of precision medicine: combination of the microbiome and extracellular vesicles. Exp Mol Med 2022;54:466–482.

8. Shin H, Choi BH, Shim O, et al. Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers. Nat Commun 2023;14:1644.

9. Schlemper RJ, Riddell RH, Kato Y, et al. The Vienna classification of gastrointestinal epithelial neoplasia. Gut 2000;47:251–255.

10. Yoo JY, Rho M, You YA, et al. 16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women. Exp Mol Med 2016;48:e208.

11. Yang J, McDowell A, Seo H, et al. Diagnostic models for atopic dermatitis based on serum microbial extracellular vesicle metagenomic analysis: a pilot study. Allergy Asthma Immunol Res 2020;12:792–805.

12. Witwer KW, Buzás EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles 2013;2:20360.

13. Skryabin GO, Vinokurova SV, Galetsky SA, et al. Isolation and characterization of extracellular vesicles from gastric juice. Cancers (Basel) 2022;14:3314.

14. Yang J, McDowell A, Kim EK, et al. Consumption of a Leuconostoc holzapfelii-enriched synbiotic beverage alters the composition of the microbiota and microbial extracellular vesicles. Exp Mol Med 2019;51:1–11.

15. Bolyen E, Rideout JR, Dillon MR, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol 2019;37:852–857.

16. Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJ, Holmes SP. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods 2016;13:581–583.

17. Aborujilah A, Mohammad Nassr R, Al-Hadhrami T, et al. Comparative study of SMOTE and bootstrapping performance based on predication methods. In: Saeed F, Mohammed F, Al-Nahari A, eds. Innovative systems for intelligent health informatics. Proceedings of the 5th International Conference of Reliable Information and Communication Technology (IRICT 2020); 2020 Dec 21-22; Langkawi. Cham: Springer, 2021:3-9.

18. Mallick H, Rahnavard A, McIver LJ, et al. Multivariable association discovery in population-scale meta-omics studies. PLoS Comput Biol 2021;17:e1009442.

19. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990;9:811–818.

20. Zeng R, Gou H, Lau HCH, Yu J. Stomach microbiota in gastric cancer development and clinical implications. Gut 2024;73:2062–2073.

21. Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med 2018;24:392–400.

22. Park JY, Kang CS, Seo HC, et al. Bacteria-derived extracellular vesicles in urine as a novel biomarker for gastric cancer: integration of liquid biopsy and metagenome analysis. Cancers (Basel) 2021;13:4687.

23. Jaye K, Li CG, Bhuyan DJ. The complex interplay of gut microbiota with the five most common cancer types: from carcinogenesis to therapeutics to prognoses. Crit Rev Oncol Hematol 2021;165:103429.

24. Heo M, Park YS, Yoon H, et al. Potential of gut microbe-derived extracellular vesicles to differentiate inflammatory bowel disease patients from healthy controls. Gut Liver 2023;17:108–118.

25. Li CC, Hsu WF, Chiang PC, Kuo MC, Wo AM, Tseng YJ. Characterization of markers, functional properties, and microbiome composition in human gut-derived bacterial extracellular vesicles. Gut Microbes 2023;15:2288200.

26. Ricci V, Carcione D, Messina S, Colombo GI, D’Alessandra Y. Circulating 16S RNA in biofluids: extracellular vesicles as mirrors of human microbiome? Int J Mol Sci 2020;21:8959.

27. Morita Y, Tadokoro S, Sasai M, Kitamoto D, Hirashima N. Biosurfactant mannosyl-erythritol lipid inhibits secretion of inflammatory mediators from RBL-2H3 cells. Biochim Biophys Acta 2011;1810:1302–1308.

28. Fischer K, Tschismarov R, Pilz A, et al. Cutibacterium acnes infection induces type I interferon synthesis through the cGASSTING pathway. Front Immunol 2020;11:571334.

29. Sá S, Fernandes R, Gestoso Á, et al. Cutibacterium acnes dysbiosis: alternative therapeutics for clinical application. Applied Sciences 2023;13:12086.

30. Cros MP, Mir-Pedrol J, Toloza L, et al. New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders. Sci Rep 2023;13:16058.

31. Zhou S, Li C, Liu L, et al. Gastric microbiota: an emerging player in gastric cancer. Front Microbiol 2023;14:1130001.

32. Karpiński TM. Role of oral microbiota in cancer development. Microorganisms 2019;7:20.

33. Dong Z, Chen B, Pan H, et al. Detection of microbial 16S rRNA gene in the serum of patients with gastric cancer. Front Oncol 2019;9:608.

34. Hao Y, Karaoz U, Yang L, et al. Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett’s esophagus and esophageal adenocarcinoma. Int J Cancer 2022;151:1703–1716.

35. Sun QH, Zhang J, Shi YY, Zhang J, Fu WW, Ding SG. Microbiome changes in the gastric mucosa and gastric juice in different histological stages of Helicobacter pylori-negative gastric cancers. World J Gastroenterol 2022;28:365–380.

36. You HS, Park JY, Seo H, Kim BJ, Kim JG. Increasing correlation between oral and gastric microbiota during gastric carcinogenesis. Korean J Intern Med 2024;39:590–602.

37. Felípez N, Montori S, Mendizuri N, et al. The human gastric juice: a promising source for gastric cancer biomarkers. Int J Mol Sci 2023;24:9131.

38. Chen M, Zhao H. Next-generation sequencing in liquid biopsy: cancer screening and early detection. Hum Genomics 2019;13:34.

39. Zhang L, Zhao M, Fu X. Gastric microbiota dysbiosis and Helicobacter pylori infection. Front Microbiol 2023;14:1153269.