Serum zinc level is associated with aortic arch calcification in incident dialysis patients

Go AS, Chertow GM, Fan D et al (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351:1296–1305. https://doi.org/10.1056/NEJMoa041031

Article  CAS  PubMed  Google Scholar 

Herzog CA, Asinger RW, Berger AK et al (2011) Cardiovascular disease in chronic kidney disease. A clinical update from kidney disease: improving global outcomes (KDIGO). Kidney Int 80:572–586. https://doi.org/10.1038/ki.2011.223

Article  PubMed  Google Scholar 

Tanaka K, Watanabe T, Takeuchi A et al (2017) Cardiovascular events and death in Japanese patients with chronic kidney disease. Kidney Int 91:227–234. https://doi.org/10.1016/j.kint.2016.09.015

Article  PubMed  Google Scholar 

Shroff R, Long DA, Shanahan C (2013) Mechanistic insights into vascular calcification in CKD. J Am Soc Nephrol 24:179–189. https://doi.org/10.1681/ASN.2011121191

Article  CAS  PubMed  Google Scholar 

Schlieper G, Schurgers L, Brandenburg V et al (2016) Vascular calcification in chronic kidney disease: an update. Nephrol Dial Transplant 31:31–39. https://doi.org/10.1093/ndt/gfv111

Article  CAS  PubMed  Google Scholar 

Voelkl J, Tuffaha R, Luong TTD et al (2018) Zinc inhibits phosphate-induced vascular calcification through TNFAIP3-mediated suppression of NF-kappaB. J Am Soc Nephrol 29:1636–1648. https://doi.org/10.1681/ASN.2017050492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakatani S, Mori K, Shoji T et al (2021) Association of zinc deficiency with development of CVD events in patients with CKD. Nutrients 13:1680. https://doi.org/10.3390/nu13051680

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Zhu Y, Li H et al (2024) Associations of whole blood zinc levels with coronary artery calcification and future cardiovascular events in CKD patients. Biol Trace Elem Res 202:46–55. https://doi.org/10.1007/s12011-023-03655-7

Article  CAS  PubMed  Google Scholar 

Kwon JH, Kim DK, Cho YE et al (2024) Zinc action in vascular calcification. Prev Nutr Food Sci 29:118–124. https://doi.org/10.3746/pnf.2024.29.2.118

Article  PubMed  PubMed Central  Google Scholar 

Chen W, Eisenberg R, Mowrey WB et al (2020) Association between dietary zinc intake and abdominal aortic calcification in US adults. Nephrol Dial Transplant 35:1171–1178. https://doi.org/10.1093/ndt/gfz134

Article  CAS  PubMed  Google Scholar 

Nagy A, Petho D, Gall T et al (2019) Zinc inhibits HIF-prolyl hydroxylase inhibitor-aggravated VSMC calcification induced by high phosphate. Front Physiol 10:1584. https://doi.org/10.3389/fphys.2019.01584

Article  PubMed  Google Scholar 

Nakatani S, Mori K, Sonoda M et al (2020) Association between serum zinc and calcification propensity (T(50)) in patients with type 2 diabetes mellitus and in vitro effect of exogenous zinc on T(50). Biomedicines 8:337. https://doi.org/10.3390/biomedicines8090337

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alcantara EH, Kwon JH, Kang MK et al (2024) Zinc deficiency promotes calcification in vascular smooth muscle cells independent of alkaline phosphatase action and partly impacted by Pit1 upregulation. Nutrients 16:291. https://doi.org/10.3390/nu16020291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sohail A, Obereigner J, Mitter G et al (2024) Association of serum zinc with mineral stress in chronic kidney disease. Clin Kidney J 17:sfae258. https://doi.org/10.1093/ckj/sfae258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Damianaki K, Lourenco JM, Braconnier P et al (2020) Renal handling of zinc in chronic kidney disease patients and the role of circulating zinc levels in renal function decline. Nephrol Dial Transplant 35:1163–1170. https://doi.org/10.1093/ndt/gfz065

Article  CAS  PubMed  Google Scholar 

Shih C-T, Shiu Y-L, Chen C-A et al (2012) Changes in levels of copper, iron, zinc, and selenium in patients at different stages of chronic kidney disease. Genom Med Biomark Health Sci 4:128–130. https://doi.org/10.1016/j.gmbhs.2013.03.001

Article  Google Scholar 

Saka Y, Naruse T, Matsumoto J et al (2021) Low serum zinc concentration is associated with infection particularly in patients with stage 5 chronic kidney disease medicated with proton pump inhibitors. J Ren Nutr 31:579–585. https://doi.org/10.1053/j.jrn.2020.11.006

Article  CAS  PubMed  Google Scholar 

Lowe NM, Fekete K, Decsi T (2009) Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr 89:2040S-S2051. https://doi.org/10.3945/ajcn.2009.27230G

Article  CAS  PubMed  Google Scholar 

Soinio M, Marniemi J, Laakso M et al (2007) Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care 30:523–528. https://doi.org/10.2337/dc06-1682

Article  CAS  PubMed  Google Scholar 

Matsuo S, Imai E, Horio M et al (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 53:982–992. https://doi.org/10.1053/j.ajkd.2008.12.034

Article  CAS  PubMed  Google Scholar 

Makino T, Saito M, Horiguchi D et al (1982) A highly sensitive colorimetric determination of serum zinc using water-soluble pyridylazo dye. Clin Chim Acta 120:127–135. https://doi.org/10.1016/0009-8981(82)90083-3

Article  CAS  PubMed  Google Scholar 

Hashimoto H, Iijima K, Hashimoto M et al (2008) Validity and usefulness of aortic arch calcification in chest X-ray. J Atheroscler Thromb 16:256–264. https://doi.org/10.5551/jat.E570

Article  Google Scholar 

Iijima K, Hashimoto H, Hashimoto M et al (2010) Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors. Atherosclerosis 210:137–144. https://doi.org/10.1016/j.atherosclerosis.2009.11.012

Article  CAS  PubMed  Google Scholar 

Woo JS, Kim W, Kwon SH et al (2016) Aortic arch calcification on chest X-ray combined with coronary calcium score show additional benefit for diagnosis and outcome in patients with angina. J Geriatr Cardiol 13:218–225. https://doi.org/10.11909/j.issn.1671-5411.2016.03.006

Article  PubMed  PubMed Central  Google Scholar 

Kanda Y (2013) Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant 48:452–458. https://doi.org/10.1038/bmt.2012.244

Article  CAS  PubMed  Google Scholar 

Ishioka K, Hidaka S, Fujiwara N et al (2023) Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients. PLoS ONE 18:e0268875. https://doi.org/10.1371/journal.pone.0268875

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotz C, Brown KH (2004) International zinc nutrition consultative group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 25:S94–S203

Google Scholar 

de Benoist B, Hill ID, Davidsson L et al (2007) Conclusions of the joint WHO UNICEF IAEA IZiNCG interagency meeting on zinc status indicators. Food Nutr Bull 28:S480–S484. https://doi.org/10.1177/15648265070283S306

Article  PubMed  Google Scholar 

Inaguma D, Morii D, Kabata D et al (2019) Prediction model for cardiovascular events or all-cause mortality in incident dialysis patients. PLoS ONE 14:e0221352. https://doi.org/10.1371/journal.pone.0221352

Article  CAS  PubMed 

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