Association Between Serum Uric Acid and Non-alcoholic Fatty Liver Disease in Non-obese Young Population: A Prospective Cohort Study

Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 2018;24:908–922. https://doi.org/10.1038/s41591-018-0104-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Younossi ZM, Golabi P, Paik JM, Henry A, Van Dongen C, Henry L. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology. 2023;77:1335–1347. https://doi.org/10.1097/hep.0000000000000004.

Article  PubMed  Google Scholar 

Zhou J, Zhou F, Wang W, Zhang XJ, Ji YX, Zhang P et al. Epidemiological Features of NAFLD From 1999 to 2018 in China. Hepatology. 2020;71:1851–1864. https://doi.org/10.1002/hep.31150.

Article  PubMed  Google Scholar 

Di Mauro S, Scamporrino A, Filippello A, Di Pino A, Scicali R, Malaguarnera R, et al. Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD. Int J Mol Sci. 2021;22(21).https://doi.org/10.3390/ijms222111905.

Lombardi R, Pisano G, Fargion S. Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD. Int J Mol Sci. 2016;17:548. https://doi.org/10.3390/ijms17040548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Copur S, Demiray A, Kanbay M. Uric acid in metabolic syndrome: Does uric acid have a definitive role? Eur J Intern Med. 2022;103:4–12. https://doi.org/10.1016/j.ejim.2022.04.022.

Article  CAS  PubMed  Google Scholar 

Cui Y, Liu J, Shi H, Hu W, Song L, Zhao Q. Serum uric acid is positively associated with the prevalence of nonalcoholic fatty liver in non-obese type 2 diabetes patients in a Chinese population. J Diabetes Complications. 2021;35:107874. https://doi.org/10.1016/j.jdiacomp.2021.107874.

Article  CAS  PubMed  Google Scholar 

Liu J, Xu C, Ying L, Zang S, Zhuang Z, Lv H et al. Relationship of serum uric acid level with non-alcoholic fatty liver disease and its inflammation progression in non-obese adults. Hepatol Res. 2017;47:E104–E112. https://doi.org/10.1111/hepr.12734.

Article  CAS  PubMed  Google Scholar 

Bai JX, Shu RM, Huang Y, Peng Z. Correlation between serum uric acid and risk of new-onset nonalcoholic fatty liver disease: a 5-year observational cohort study. Zhonghua Gan Zang Bing Za Zhi. 2018;26:271–275. https://doi.org/10.3760/cma.j.issn.1007-3418.2018.04.008.

Article  CAS  PubMed  Google Scholar 

Li J, Zou B, Yeo YH, Feng Y, Xie X, Lee DH et al. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2019;4:389–398. https://doi.org/10.1016/s2468-1253(19)30039-1.

Article  PubMed  Google Scholar 

Fan JG, Kim SU, Wong VW. New trends on obesity and NAFLD in Asia. J Hepatol. 2017;67:862–873. https://doi.org/10.1016/j.jhep.2017.06.003.

Article  PubMed  Google Scholar 

Wu S, Huang Z, Yang X, Zhou Y, Wang A, Chen L et al. Prevalence of ideal cardiovascular health and its relationship with the 4-year cardiovascular events in a northern Chinese industrial city. Circ Cardiovasc Qual Outcomes. 2012;5:487–493. https://doi.org/10.1161/circoutcomes.111.963694.

Article  PubMed  Google Scholar 

Unger T, Borghi C, Charchar F, Khan NA, Poulter NR, Prabhakaran D et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020;75:1334–1357. https://doi.org/10.1161/hypertensionaha.120.15026.

Article  CAS  PubMed  Google Scholar 

Jia W, Weng J, Zhu D, Ji L, Lu J, Zhou Z et al. Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev. 2019;35:e3158. https://doi.org/10.1002/dmrr.3158.

Article  PubMed  Google Scholar 

Gao X, Fan JG. Diagnosis and management of non-alcoholic fatty liver disease and related metabolic disorders: consensus statement from the Study Group of Liver and Metabolism. Chinese Society of Endocrinology. J Diabetes. 2013;5:406–415. https://doi.org/10.1111/1753-0407.12056.

Article  Google Scholar 

Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511. https://doi.org/10.1161/01.cir.0000052939.59093.45.

Article  PubMed  Google Scholar 

Levey AS, de Jong PE, Coresh J, El Nahas M, Astor BC, Matsushita K et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011;80:17–28. https://doi.org/10.1038/ki.2010.483.

Article  PubMed  Google Scholar 

Ye Q, Zou B, Yeo YH, Li J, Huang DQ, Wu Y et al. Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020;5:739–752. https://doi.org/10.1016/s2468-1253(20)30077-7.

Article  PubMed  Google Scholar 

Zhou F, Zhou J, Wang W, Zhang XJ, Ji YX, Zhang P et al. Unexpected Rapid Increase in the Burden of NAFLD in China From 2008 to 2018: A Systematic Review and Meta-Analysis. Hepatology. 2019;70:1119–1133. https://doi.org/10.1002/hep.30702.

Article  PubMed  Google Scholar 

Ballestri S, Nascimbeni F, Romagnoli D, Lonardo A. The independent predictors of non-alcoholic steatohepatitis and its individual histological features.: Insulin resistance, serum uric acid, metabolic syndrome, alanine aminotransferase and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment. Hepatol Res. 2016;46:1074–87.https://doi.org/10.1111/hepr.12656.

Lee YJ, Lee HR, Lee JH, Shin YH, Shim JY. Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. Clin Chem Lab Med. 2010;48:175–180. https://doi.org/10.1515/cclm.2010.037.

Article  CAS  PubMed  Google Scholar 

Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M, Jalal DI. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013;62:392–399. https://doi.org/10.1016/j.metabol.2012.08.013.

Article  CAS  PubMed  Google Scholar 

Wei F, Li J, Chen C, Zhang K, Cao L, Wang X et al. Higher Serum Uric Acid Level Predicts Non-alcoholic Fatty Liver Disease: A 4-Year Prospective Cohort Study. Front Endocrinol (Lausanne). 2020;11:179. https://doi.org/10.3389/fendo.2020.00179.

Article  PubMed  PubMed Central  Google Scholar 

Della Torre S. Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology. Cells. 2021;10. https://doi.org/10.3390/cells10092502.

Della Torre S. Non-alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling. Front Endocrinol (Lausanne). 2020;11:572490. https://doi.org/10.3389/fendo.2020.572490.

Article  Google Scholar 

Mumford SL, Dasharathy SS, Pollack AZ, Perkins NJ, Mattison DR, Cole SR et al. Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study. Hum Reprod. 2013;28:1853–1862. https://doi.org/10.1093/humrep/det085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Zhang Y, Graham S, Wang X, Cai D, Huang M et al. Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping. J Hepatol. 2020;73:263–276. https://doi.org/10.1016/j.jhep.2020.03.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim EY, Lee HW, Lee JW, Kwon YJ, Son NH. Trends in serum uric acid levels among Korean children and adolescents between 2016 and 2020: a nationwide study. Eur J Pediatr. 2023;182:2253–2261. https://doi.org/10.1007/s00431-023-04904-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali N, Miah R, Hasan M, Barman Z, Mou AD, Hafsa JM et al. Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults. Sci Rep. 2020;10:7841. https://doi.org/10.1038/s41598-020-64884-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruggiero C, Cherubini A, Ble A, Bos AJ, Maggio M, Dixit VD et al. Uric acid and inflammatory markers. Eur Heart J. 2006;27:1174–1181. https://doi.org/10.1093/eurheartj/ehi879.

Article  CAS  PubMed 

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