Polyzos SA, Kountouras J, Mantzoros CS. Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics. Metabolism. 2019;92:82–97.
Article PubMed CAS Google Scholar
Li L, Liu D-W, Yan H-Y, Wang Z-Y, Zhao S-H, Wang B. Obesity is an independent risk factor for non-alcoholic fatty liver disease: evidence from a meta-analysis of 21 cohort studies. Obes Rev. 2016;17:510–9.
Article PubMed CAS Google Scholar
Polyzos SA, Kountouras J, Mantzoros CS. Adipose tissue, obesity and non-alcoholic fatty liver disease. Minerva Endocrinol. 2017;42:92–108.
Makri E, Goulas A, Polyzos SA. Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease. Arch Med Res. 2021;52:25–37.
Article PubMed CAS Google Scholar
Polyzos SA, Mantzoros CS. Metabolic dysfunction-associated steatotic liver disease: Recent turning points for its diagnosis and management. Metabolism. 2024;157:155936.
Polyzos SA, Kechagias S, Tsochatzis EA. Review article: non-alcoholic fatty liver disease and cardiovascular diseases: associations and treatment considerations. Aliment Pharmacol Ther. 2021;54:1013–25.
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023;79:1542–56.
Article PubMed CAS Google Scholar
Polyzos SA, Kountouras J, Zavos C, Deretzi G. Nonalcoholic fatty liver disease: multimodal treatment options for a pathogenetically multiple-hit disease. J Clin Gastroenterol. 2012;46:272–84.
Zaidi M, Zaidi S, Yuen T. Understanding osteokine biology. Cell Metab. 2024;36:888–90.
Article PubMed CAS Google Scholar
Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, et al. An integrated multi-omics analysis reveals osteokines involved in global regulation. Cell Metab. 2024;36:1144-1163.e7.
Article PubMed CAS Google Scholar
Shimonty A, Bonewald LF, Huot JR. Metabolic health and disease: A role of osteokines? Calcif Tissue Int. 2023;113:21–38.
Article PubMed CAS Google Scholar
Vachliotis ID, Anastasilakis AD, Goulas A, Goulis DG, Polyzos SA. Nonalcoholic fatty liver disease and osteoporosis: A potential association with therapeutic implications. Diabetes Obes Metab. 2022;24:1702–20.
Article PubMed CAS Google Scholar
Drapkina OM, Elkina AY, Sheptulina AF, Kiselev AR. Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives. Int J Mol Sci. 2023;24:8445.
Article PubMed PubMed Central CAS Google Scholar
Azizieh FY, Shehab D, Al Jarallah K, Mojiminiyi O, Gupta R, Raghupathy R. Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD. J Inflamm Res. 2019;12:99–108.
Article PubMed PubMed Central CAS Google Scholar
Filip R, Radzki RP, Bieńko M. Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis. Clin Interv Aging. 2018;13:1879–91.
Article PubMed PubMed Central CAS Google Scholar
Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease. Metabolism. 2016;65:1062–79.
Article PubMed CAS Google Scholar
Shu L, Fu Y, Sun H. The association between common serum adipokines levels and postmenopausal osteoporosis: A meta-analysis. J Cell Mol Med. 2022;26:4333–42.
Article PubMed PubMed Central CAS Google Scholar
Santos JPMD, de Maio MC, Lemes MA, Laurindo LF, Haber JFDS, Bechara MD, et al. Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. Int J Mol Sci. 2022;23:498.
Article PubMed PubMed Central CAS Google Scholar
Ehnert S, Aspera-Werz RH, Ruoß M, Dooley S, Hengstler JG, Nadalin S, et al. Hepatic osteodystrophy-molecular mechanisms proposed to favor its development. Int J Mol Sci. 2019;20:2555.
Article PubMed PubMed Central CAS Google Scholar
Polyzos SA, Anastasilakis AD, Efstathiadou ZA, Yavropoulou MP, Makras P. Postmenopausal osteoporosis coexisting with other metabolic diseases: Treatment considerations. Maturitas. 2021;147:19–25.
Article PubMed CAS Google Scholar
Zhao J, Lei H, Wang T, Xiong X. Liver-bone crosstalk in non-alcoholic fatty liver disease: Clinical implications and underlying pathophysiology. Front Endocrinol. 2023;14:1161402.
Fukumoto S, Martin TJ. Bone as an endocrine organ. Trends Endocrinol Metab. 2009;20:230–6.
Article PubMed CAS Google Scholar
Wei J, Karsenty G. An overview of the metabolic functions of osteocalcin. Curr Osteoporos Rep. 2015;13:180–5.
Polyzos SA, Kountouras J, Zavos C. Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr Mol Med. 2009;9:299–314.
Article PubMed CAS Google Scholar
Zhang M, Nie X, Yuan Y, Wang Y, Ma X, Yin J, et al. Osteocalcin alleviates nonalcoholic fatty liver disease in mice through GPRC6A. Int J Endocrinol. 2021;2021:9178616.
Article PubMed PubMed Central Google Scholar
Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G. Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone. 2012;50:568–75.
Article PubMed CAS Google Scholar
Du J, Zhang M, Lu J, Zhang X, Xiong Q, Xu Y, et al. Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK. Endocrine. 2016;53:701–9.
Article PubMed CAS Google Scholar
Zhang X-L, Wang Y-N, Ma L-Y, Liu Z-S, Ye F, Yang J-H. Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway. Acta Pharmacol Sin. 2020;41:383–93.
Article PubMed CAS Google Scholar
Gupte AA, Sabek OM, Fraga D, Minze LJ, Nishimoto SK, Liu JZ, et al. Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome. Endocrinology. 2014;155:4697–705.
Article PubMed PubMed Central Google Scholar
Musso G, Paschetta E, Gambino R, Cassader M, Molinaro F. Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver. Trends Mol Med. 2013;19:522–35.
Article PubMed CAS Google Scholar
Otani T, Mizokami A, Kawakubo-Yasukochi T, Takeuchi H, Inai T, Hirata M. The roles of osteocalcin in lipid metabolism in adipose tissue and liver. Adv Biol Regul. 2020;78: 100752.
Article PubMed CAS Google Scholar
Patti A, Gennari L, Merlotti D, Dotta F, Nuti R. Endocrine actions of osteocalcin. Int J Endocrinol. 2013;2013: 846480.
Comments (0)